anesthetics Flashcards

1
Q

5 general benefits/uses of anesthesia drugs?

A
Sedation and reduced anxiety
Lack of awareness and amnesia
Skeletal muscle relaxation
Suppression of undesirable reflexes
Analgesia
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

can one drug do all five benefits/uses of anesthesia drugs?

A

NO, generally combine IV and inhaled to maximize effects and avoid ADRs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

which is cheaper and easier to use? IV or inhaled anesthetics?

A

IV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

what do IV anesthetics do? what are they used for? (used alone, vs adjunct, vs continual infusions)

A

rapid induction of anesthetic effect

  • alone: short procedures, anesthesia
  • continual infusions: longer procedures
  • adjuncts: to inhaled
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what is the one IV barbituate anesthetic agent?

A

methohexital (brevital)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is the MOA of methohexital (brevital)?

A

binds barbiatuate site on GABAa receptor

–> enhance Cl- channel opening to increase GABA inhibitory effect on the receptor.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

how long does it take methohexital (brevital) to work?

A

fast, 30 sec. rapid induction of sleep

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

2 ADRs of methohexital?

A
  1. respiratory depression

2. hypotension (from VasoDilation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what is the MOA of IV propofol and IV Etomidate, ?

A

binds beta subunit on GABAa receptor

–> enhance GABA inhibitory effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is the major benefit of IV propofol over IV methohexital ?

A

kinetics: rapid on, rapid off receptor.

- Recovery is better- less N/V

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what are the kinetics of IV propofol?

A

rapid!

onset- 30sec, rapid metabolism, short 1/2 life (30-60min)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

3 ADRs of IV propofol? (maybe weeds)

A

Apnea, decrease cardiac output, hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

drug of choice for shorter ambulatory procedures in the OR? what is used prior to admin of other anesthesias?

A

short in OR: IV propofol

prior: IV ketamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

when would you choose to use IV etomidate? (over propofol)

A

if BP low before surgery – agent has minimal cardiac and respiratory depression
only Side Effects:
Nausea/vomiting on emergence from anesthesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what is the 2 part MOA of IV ketamine?

A
  1. blocks NMDA glutamate (excitatory) receptor in CNS = rapid hypnotic state
  2. mu opiod agonist - analgesic effects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

which IV drug Produces rapid hypnotic state (dissociative anesthesia) where patient exhibit analgesia, are unresponsive to commands, have amnesia, their eyes may open and limbs move involuntarily?

A

IV ketamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

what are the two major advantages of IV ketamine over other anesthetics?

A

1 . No risk for hypotension or bronchospasm
(increases HR, BP & cardiac output)
2. Pediatric procedures: @ low doses in combo with others (propofol &/or midazolam)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

what would you use for a short painful procedure on a kid (like burn dressing change)?

A

IV ketamine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

ADRs of IV ketamine?

A

illusions

increases HR, BP and CO

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

major MOA of inhaled anesthetics?

A

bind beta subunit on GABAa (inhibitory) receptor

same as IV propofol and Etomidate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

what are the 3 other MOAs of inhaled anesthetics? what do they all lead to?

A
  1. inhibit NMDA receptors
  2. activates K+ channels
  3. inhibits nicotinic (excitatory) receptor- activated cation channels
    - -> hyperpolarization and reduced membrane excitability
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

onset and duration of inhaled anesthetics? (maybe weeds)

A

onset: 2-3min
duration: <2hrs

23
Q

5 ADRs of inhaled anesthetics?

A
shivering
blurry vision 
weak for a few days following after administration 
*Rare: hepatotox
*Rare: malignant hyperthermia
24
Q

two types of inhaled anesthetics

A
  1. inhaled gas - nitrous oxide

2. volatile agents (liquid turns to gas)- “-fluranes”

25
what was "tweaked" to create the volatile inhaled agents "-fluranes"? why? (weeds)
Halothane - tweaked b/c ADRs were bad
26
what are the local anesthetics?
"-aine" s | *cocaine was the original
27
MOA of local anesthetics? ("-aine"s)
reversible inhibition: bind Na+ channel, decrease nerve membrane permeability to Na+ - -> axn potential can't propegate - -> sensory input lost (pain and temp)
28
what happens with repeated injections of local anesthetics? ("-aine"s)?
tachyphylaxis: loses effectiveness
29
what are the 2 groups that the local anesthetics are broken into?
esters and amides
30
which drugs are in the ester local anesthetic group?
COCAINE PROcaine chloroPROcaine TETRAcaine
31
which drugs are in the amide local anesthetic group?
Prilocaine Lidocaine "-vacaine"s
32
which are the longest acting local anesthetics?
``` bupi-vacaine, ropi-vacaine ("V caine is VERY long lasting ") and Tetracaine (think "4 times as fast") ```
33
which are the shortest acting local anesthetics?
Procaine and chloroprocaine | " PROs need to recover QUICK"
34
what is the most important factor for determining DOA and potential for Tox with local anesthetics?
local blood flow: | anesthetic cause vasodilation= rapid drug abs and systemic abs. = increased toxicity
35
how can you avoid the short DOA and toxicity risk with local anesthetic? (weeds)
give epi with it | Epi vasoconstricts = longer DOA, less systemic abs and less toxicity
36
local anesthetic effect in injured tissue ?
injured tissue = inflammation and acidosis --> lower pH = ionization of local anesthetics (need to be NON-ionized in order to get into cell and have effect) OVERALL: doesn't work as well
37
where can you NOT use local anesthetic w/ epi ?
where vasoconstriction could result in permanent tissue destruction Nose, ear, penis, or ends of digits (fingers and toes), peripheral vascular disease
38
what are the two systemic toxicity complications that come from abs. of too much local anesthetics ?
CNS/neuro | Cardiovascular
39
CNS/neuro tox from too much local anesthetic abs?
numb tongue + metallic taste nystagmus + muscle twitch seizure + CNS depression
40
cardiovascular tox from too much local anesthetic abs?
bradycardia, severe hypotension, cardiac arrest
41
what is the one exception from usual cardiovasc. tox progression from too much local anesthetic abs?
cocaine: vasoconstriction, HTN, & ventricular arrhythmia Vasoconstriction= ischemia (why you see ulceration of membranes & damage to septum occur when abused nasally)
42
what drug combo is used to make cream to numb area: apply before venipunture (for putting in port for chemo) ? (weeds)
prilocaine/lidocaine (EMLA) cream
43
what drug is used to make lozanges/gels for teeth pain? (weeds)
benzocaine
44
what drug is this... IV/IM drug of choice for preoperative sedation, anxiety and amnesia Causes high amnesia – often given before entering OR
a benzodiazepine (Midazolam aka Versed) injectable
45
when are opiods used with anesthetics?
low dose opioids: premedication & adjunct ...as adjunct: decrease pain so don’t need as high a dose to achieve anesthesia * In high risk surgery to minimize CV depression
46
what two anticholinergics are used with anesthetics? why?
atropine and glycopyrolate - restore cardiac rate (prevent reflex brady) and BP during anesthesia (stimulates M2)
47
anesthesia adjunct: to relieve anxiety
benzodiazepine
48
anesthesia adjunct: to prevent gastric acid secretions
H2 blockers
49
anesthesia adjunct: prevent allergic rxns
antihistamines
50
anesthesia adjunct: prevent aspiration of gastric acid secretions, post-op N/V
antiemetics
51
anesthesia adjunct: to provide analgesia
opioids
52
anesthesia adjunct: to prevent bradycardia + secretion of fluids into respiratory tract
anticholinergics
53
anesthesia adjunct: to facilitate intubation + relaxation
neuromuscular blocking agents