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Brain and Behavior Part 2 - My Cards > Anesthesia - Sedatives And Hypnotics > Flashcards

Anesthesia - Sedatives And Hypnotics Flashcards

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The Brain flashcards
0
Q

Not having pain

A

Analgesia

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1
Q

Not feeling

A

Anesthesia

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2
Q

Blunting of consciousness

A

Sedation

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3
Q

What drugs do anesthesia providers abuse? Psychiatrists?

A

Opiods; benzodiazepines

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4
Q

How drugs get to the effect site; what body does to drug

A

Pharmacokinetics

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5
Q

Drug effect as a result of receptor binding;

What drug does to the body

A

Pharmacodynamics

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6
Q

Some things to consider when thinking about pharmacokinetics

A

Route of administration
Metabolism
Distribution
Elimination

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7
Q

Some things to consider when thinking about pharmacodynamics

A

Receptor agonist, antagonist
Genetic variability in receptor density
Dose response
Efficacy, potency, toxicity

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8
Q

When ppl talk about half life of an anesthetic are they talking about distribution or elimination half life?

A

Distribution half life; only care about elimination half life for drugs you are giving longer

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9
Q

What are contraindications for propofol?

A

Allergy to EGG and propofol

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10
Q

What are cardiovascular effects of propofol?

A

Hypotension - decreased sympathetic tone, decreased vascular tone, myocardial depression(?)
Variable heart rate

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11
Q

What are respiratory effects of propofol?

A

Hypopnea or apnea - Decreased tidal volume
Decreased response to hypocarbia and hypoxia
Bronchodilation

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12
Q

“milk of amnesia” refers to which drug?

A

Propofol

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13
Q

Major clinical use of propofol?

A

Induction of general anesthesia

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14
Q

Does propofol affect pain levels?

A

NO effect on pain!

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15
Q

List 4 receptors that propofol binds?

A

Beta subunit of GABAa
Alpha2 adrenoreceptors
NMDA glutamate receptors
Glycine receptors

16
Q

What is propofol related infusion syndrome?

A

Life threatening metabolic acidosis, do not infuse propofol for more than 72 hours

17
Q

Etomidate cardiovascular effects?

A

Moderate hypotension, few neg effects

18
Q

Etomidate respiratory effects?

A

Minimal to moderate

19
Q

Etomidate absolute contraindications?

A

Allergy to etomidate

20
Q

Etomidate neurological effects?

A

Decreased cerebral metabolic rate, burst suppression
Decreased cerebral blood flow
Can cause seizures

21
Q

Etomidate adverse effects?

A

Adrenal suppression in critically ill patients

Increased post-operative nausea and vomiting relative to propofol

22
Q

Etomidate general use?

A

Induction of general anesthesia, mostly for known or anticipated hemodynamic instability, also for critically ill, cardiac anesthesia

23
Q

Does etomidate affect pain?

A

No

24
Q

Which is more important for anesthetics: redistribution or elimination?

A

Redistribution!

Brain and Behavior Part 2 - My Cards (8 decks)

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