Anesthesia for Thyroid Parathyroid Procedures Flashcards

1
Q

What is an example of indications for Thyroid Disease?

A

Grave’s Disease
Thyroid Nodule
Multinodular Goiter
Thyroid Cancer

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2
Q

What is an example of indications for Parathyroid Disease?

A

Primary Hyperparathyroidism (Only1 gland involved 80% cases)
Hypercalcemia
Parathyroid Adenoma
Parathyroid Cancer

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3
Q

Describe Thyroid Arterial Blood Supply.

A

Superior thyroid artery (branch of external carotid artery)
Inferior thyroid artery (branch of the thyrocervical trunk)
Anatomical variant the thyroid internal mammery artery (which has a variable origin/ex. aorta)
4-6cc/min/gram

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4
Q

Thyroid Venous Drainage is carried out by which veins?

A

Venous drainage is carried out by the superior, middle and inferior thyroid veins, which form a venous plexus

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5
Q

Which Nerve is of greatest concern for injury during thyroid or parathyroid surgery?

Where does this nerves name originate?

A

Clinical Relevance: Recurrent Laryngeal Nerve gets its name from the fact that it loops below the aorta on its way to the intrinsic muscles of the larynx. The RLN arise from their respective vagus nerves, and descend into the chest.
The left recurrent laryngeal nerve passes under and around the aorta on its way to the larynx, whereas the right recurrent laryngeal nerve passes under and around the subclavian artery.

During surgery on the thyroid gland, care must be taken not to ligate or damage the recurrent laryngeal nerves.

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6
Q

Describe the Anatomy & Physiology of the Thyroid Gland.

A

The thyroid is a highly vascular gland located anterior to the trachea in the lower neck (just below cricoid cartilage), extending from the level of the 5th cervical vertebra down to the 1st thoracic. Shaped from an H to a U and has 2 elongated lateral lobes with superior and inferior poles connected by a median isthmus, overlying the second to fourth tracheal rings.

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7
Q

What is the Primary Goal for patients with Thyroid Disease?

A

Ensure Euthyroid state prior to procedure if possible.

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8
Q

Assessment & Patient History

A

Elicitation of symptoms r/t thyroid disease & co-morbid medical diseases
Voice Change?
History of difficulties encountered during normal breathing
Dyspnea
Orthopnea (is patient propped up with pillows or need for sleeping?)
Dysphagia
Stidor or breathlessness with supine position
Risk of MEN syndrome with above symptoms (MEN Multiple Endocrine Neoplasia Syndrome) is a rare genetic disorder of abnormal growth of endocrine tumors or enlarged gland growth
Pre-operative Ultrasound of neck (lymph nodes) if malignancy suspected

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9
Q

Which multi-disciplinary care providers would be included in a multidisciplinary approach for a patient with thyroid / parathyroid disease?

A
Endocrinologist
Surgeon
Cardiologist
Radiologist
Anesthesiologist
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10
Q

What are extreme examples of thyroid dysfunction?

A

Hyperthyroidism
Watch for Thyroid Storm (Thyrotoxicosis)

Hypothyroidism
Watch for Myxedema Coma

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11
Q

What are some areas to look into when assessing for co-morbid diseases?

A

Cardiac disease

Respiratory disease

Other endocrine disorders

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12
Q

How can you identify Signs of tracheal compression and vocal cords palsy?

A

Examination of Goiter
Size
Consistency
Duration and extent of enlargement
Fixed and hardness of gland (malignancy?)
Inability to feel lower border of thyroid gland consider retrosternal extension
Retrosternal extension may cause Superior Venocaval Obstruction Syndrome (SVC Syndrome)
May see pleural and pericardial effusion
May see Horner’s syndrome (Classic Triad: Miosis, Partial Ptosis & Anhidrosis)

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13
Q

What is Horner’s syndrome

A

results from an interruption of the sympathetic nerve supply to the eye and is characterized by the classic triad.
Classic Triad: Miosis, Partial Ptosis & Anhidrosis
Transient Horner syndrome is a well-known side effect of stellate ganglion block, interscalene block of the brachial plexus, and occasionally epidural analgesia.
May also be caused by Lesions of the Pontine, lesions thalamus &/or hypothalamus, such as tumor or hemorrhage.

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14
Q

In Airway Evaluation, what are predictors of Impossible Mask Ventilation?

A
Male
Beard
Obstructive sleep apnea (moderate to severe, requiring PAP treatment)
Mallampati III or IV
H/of neck radiation
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15
Q

In Airway Evaluation, what are Predictors of Difficult Face Mask Ventilation?

A
Age > 57 y.o.
Body Mass Index ≥ 30 kg/m2
Beard
Snoring or OSA
Lack of teeth
Mallampati III or IV
Limited mandibular protrusion
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16
Q

A potential difficult airway with planned DVL should include at least two clearly defined backup airway management plans READILY AVAILABLE. What are some backup plans?

A

Video laryngoscopy (e.g., Glidescope) will often improve airway visualization
LMA-Fastrach™ provides rescue ventilation with a 95-100% success rate in difficult airway situations.
Optimize patient position
Have intubating aids readily available Bougie, Stylettes

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17
Q

Which Thyroid and Parathyroid disease factors surround Airway Evaluations & History / Physical Findings?

A

Anatomic characteristics (e.g., ↓ C-spine ROM, large tongue, receding jaw, etc.)
Hx of stridor and hoarseness (airway narrowing and possible vocal cord (VC) dysfunction)
Previous Hx of neck surgery, trauma, or XRT (↓ compliance of the tissues, ↓ neck ROM, ↓ mouth opening)
Previous Hx of difficult intubation
Infections (e.g., epiglottitis, retropharyngeal abscess, Ludwig’s angina)

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18
Q

Why would an indirect laryngoscopy be performed prior to a thyroid or parathyroid procedure?

A

To assess vocal cord movement prior to procedure (and sometimes after procedure)
Consider an indirect laryngoscopy prior to thyroid surgery by ENT specialist
3-5% of population has unilateral paralysis of vocal cords
ENT may assist in surgical airway if needed

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19
Q

What type of Radiological investigations should be considered for thyroid/parathyroid procedures?

Large thyroid gland?

A

X Rays of Chest & Neck should be reviewed

Large thyroid gland and retrosternal extension, computed tomography (CT) scan or magnetic resonance imaging (MRI) is preferable to delineate the exact location and extension

May obtain diagnosis of Tracheal Stenosis with spiral CT scan

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20
Q

Describe Pre-op Preparation & Premedication for Elective surgery in Hyperthyroid patients.

A

Hyperthyroid patients:
Increased vascularity of thyroid (due to carbimazole) may predispose to higher bleeding
Infection risk secondary to decreased WBCs (carbimazole Side Effect)
Beta Blockers used to stabilize cardiovascular status (avoid CV overstimulation– a-fib, exaggerated hypertension and thyroid storm)

21
Q

Describe Pre-op Preparation & Premedication for Elective surgery in Hypothyroid patients.

A

Hypothyroid patients:
Pre-op levels of exogenous hormones rise with treatment (may lead to peri-operative cardiac complications ischemia & infarctions due to oxygen demand & supply ratio)
May see depressed myocardial function, impaired barorecepor reflex mechanism, depressed ventilatory drive, decreased plasma & RBC volume, hypoglycemia & impaired hepatic metabolism
Myxedema Coma is an Emergency Situation (seen w profound hypothyroidism)

22
Q
How does Hyperthyroidism affect the following:  ?
HR
SVR
Cardiac output
Cardiac contractility
A

Heart rate ↑
Systemic vascular resistance ↓
Cardiac output ↑
Cardiac contractility ↑

23
Q
How does Hyporthyroidism affect the following:  ?
HR
SVR
Cardiac output
Cardiac contractility
A

Heart rate ↓
Systemic vascular resistance ↑
Cardiac output ↓
Cardiac contractility ↓

24
Q

What medications would be considered Pre-operatively for emergency thyroid surgery?

A

Beta Blockers (caution w precipitation of CHF or Bronchospasm COPD)
Corticosteroids
Anti-thyroid drugs
Iodine (has varied practice for use in pre operative preparation with emergent surgery not always possible to give due to urgency of surgery)

25
Q

What Anesthesia Techniques could be considered for thyroid and parathyroid surgery?

A

Bilateral Superficial Cervical Plexus Blocks

General Anesthesia with endotracheal intubation safe approach

26
Q

Preparation for General Anesthesia with endotracheal intubation includes:

A
  • glycopyrrolate if needed for reduced secretions caution w cardiac disease (caution with atropine)
  • Adequate Pre-oxygenation especially if difficult airway
  • Shorter acting opioids
  • Consider dexmedetomidine
  • Consider TIVA (Propofol rapid onset, rapid recovery & anti-emetic actions)
  • Difficult airway
  • No paralysis if (nerve monitoring or neck dissection combination). May use depolarizing agent if needed for intubation.
27
Q

If patient has History of or Suspected Difficult Airway?

A

Always review old records if available
Caution with premedication
Consider withholding premedication if difficult airway
History of Radiation? Have suspicion for difficulty airway

28
Q

When Setting Up you OR Room:

What is Your Plan A?
What is Your Plan B?

A
Fiber-optic, 
Glide, 
LMA, 
Bougie, 
Airway exchange catheter
IV & arterial lines
Nerve monitors
Specialty ETT’s
Do you know where the Jet Ventilator is located?
Hollinger Laryngoscope (surgery)
Ventilating Rigid Bronchoscope (surgery)
Available Staff (surgeon, anesthesiologist, CRNA all present at pre-time out)
29
Q

Which Patients would be associated with a significantly increased risk of operative recurrent laryngeal nerve injury?

A

Thyroid carcinoma,

Re-operation for recurrent goiter

Non-identification of RLN

Total thyroidectomy

30
Q

What is the Incidence of Recurrent Laryngeal Nerve Injury for experienced neck surgeons?

What about surgeons with Less Experience? Does it increase or remain the same?

A

The incidence of RLN Injuries 1% to 2% (experienced neck surgeons)
This incidence is higher when thyroidectomy is performed by a less experienced surgeon, or when thyroidectomy is done for a malignant disease.
Sometimes the nerve is purposely sacrificed if it runs into an aggressive thyroid Cancer.
In the present study, the rate of RLNI was 4.1%

31
Q

When positioning a patient for Thyroid / Parathyroid Surgery, what needs to be considered?

A

padded ring under the head
a rolled sheet (or gel) under the shoulders
Protect arms as they are usually tucked at sides. Check arms (AND LEGS for position) throughout case
Pad areas near tubing’s (ex. BP cuff tubing on skin)
eyes covered protected proptosis & exophthalmos
head‑up position
have access needs for IV infusion and blood draw & verify prior to draping

32
Q

What are your Intra-operative Monitoring needs/concerns for patients undergoing thyroid/parathyroid procedures?

A
  • hemodynamic complications, monitor cardiac status
  • hypovolemia may contribute to hypotension
  • consider invasive monitors if significant cardiac history
  • respiratory complications
  • Monitoring of temperature risks of developing hyperthermia and hypothermia in thyroid disease
  • Eye protection required (may have exopthalmia)
  • Muscle relaxant use as indicated. No if nerve monitors
  • Patients with thyrotoxicosis predisposed to cardiomyopathy & increased risk myopathies & myasthenia gravis
33
Q

What are the Basic principles of IONM?

intraoperative nerve monitoring

A

IONM is based on the principle of electrophysiology, the motor nerve is stimulated by electricity during the surgery, and then the nerve impulses are formed and transferred to the dominant muscles to produce myoelectric signals, forming waves and alerts in electromyography (EMG), which will help the surgeons to judge the functional integrity of nerves

34
Q

Describe Anesthetic Plan of Care when using IONM:

A

Planned in advance as a specialty service: Monitoring of the Recurrent Laryngeal Nerve (X) during thyroid surgery. Especially used in high risk for nerve damage
No paralysis during procedure (only depolarizing agent for induction)
Place specialty ETT with video scope for visualization of correct placement
Reaffirms false reassurance associated w incorrect ETT placement
Avoid topical Lidocaine
Consider remifentanil infusion

35
Q

Describe Medication Considerations when caring for a patient with Thyroid Disease.

A
Avoid drugs that stimulate SNS 
Ex. Ketamine, pancuronium, atropine, ephedrine	
Consider TIVA
Propofol infusion
Remifentanyl infusion
Multimodal Pain Management
Alpha 2 Agonist
Dexmedetomidine 
Reduce doses of narcotics required
Tylenol (Ofirmiv)
Gabapentin
Anti-nausea agents prevent PONV
Dexamethasone
5HT-3 Antagonists
36
Q

What are some Anesthetic Considerations when caring for patients with Thyroid and Parathyroid Disease? Part I

A

-Difficult Airway
Enlarged goiter may cause tracheal deviation compression or shifting
-Co-morbidity of diseases (cardiac and thyroid)
-IV access & blood draw access
Intraoperative Parathyroid Assay Blood Draws may be required (confirms adequate removal of PTH)
-Monitoring Needs for procedure (non invasive & invasive lines, etc.)
Hemodynamic complications
Respiratory complications
Temperature (hyperthermia & hypothermia risks with thyroid disease)
Monitor Position of patient Watch arms and legs (slide, movement, etc.), May turn OR table 90-180º away from anesthesia provider (document)
Monitor Position of ETT With use of NIMS
Adequately secured
-Prevent stressful extubation (no coughing or bucking movements) Avoid hemorrhage

37
Q

What are some Anesthetic Considerations when caring for patients with Thyroid and Parathyroid Disease? Part II

A

Assessment of vocal cord injury may include aking patient to speak letter “e” or word “moon”
Incidence of hyperthyroid patients having Myasthenia Gravis (watch NMBA’s if used)
Intra-operative steroids useful for edema & PONV
Hyperthyroid patient may be hypovolemic (induction drop in BP)
Recurrent Laryngeal nerve palsy Can cause Hoarseness if Unilateral
Recurrent Laryngeal nerve palsy Can cause Stidor if Bilateral
Caution with deep extubation be prepared to re-intubate or surgical airway available
May identify vocal cord function by DL after deep extubation if there is concern of injury.
Valsalva maneuver in Trendelenburg position is carried out to check hemostasis
Possibility of Tracheomalacia & vocal cord palsy should be kept in mind
Radiation may increase difficulty of intubation

38
Q

What are some of the Surgical risks of Thyroidectomy/Parathyroidectomy?

A

Hypoparathyroidism (permanent about 1%; temporary very common)
Hemorrhage/hematoma- airway compromise may require immediate opening of incision
Laryngeal edema
Recurrent Laryngeal Nerve Injury
Superior laryngeal Nerve Injury
Tracheomalacia
Pneumothorax (w retrosternal resection rare, be aware of possibility, Best Treatment Early Detection & Needle 2nd anterior intercostal space)
Thyroid Storm (w severe illness or poor prep for surgery, rare but can be fatal—only hyperthermia, tachycardia and cardiac arrhythmias can be seen during GA; Treatment B Blockers cooling patient & steroids)
Myxedema Coma
Hypocalcemia
PONV
PAIN

39
Q

What is The Fire Triangle?

Can you identify Sources of Fire?

A

The Fire Triangle A central concept of fire prevention is the fire triangle. It is based on the fact that in order for a fire to start, it requires oxygen, heat and fuel. The Triangle also designates who is responsible for managing each part.

  • Oxygen is an oxidizing source (Anesthesia)
  • Heat is an ignition source (Surgeon)
  • Fuel is any material that has the ability to catch fire (Nurse/Tech)

EXAMPLES/Sources:
• Oxidizers include: o Oxygen o Nitrous oxide
• Igniters include: o Elecrocautery devices o Active electrosurgical electrodes & lasers o Fiber-optic light cords and flexible endoscopes o Defibrillators o Cutting devices, heated probes and anything that creates heat
• Fuels include: o Flammable prep agents, sponges, drapes, tape, bandages, dressings o Towels, aerosols, plastics, hair o Petroleum and oil-based lubricants or ointments o Methane gas from the gastrointestinal tract and alcohol vapors

40
Q

Anesthesia Patient Safety Foundation (APSF) Fire Algorithm

A

Just Review for your practice, it’s on slide 44

OR Fire Prevention Algorithm

41
Q

Describe Intraoperative parathyroid assay.

A

Initial blood sample PTH is obtained just prior to incision
Blood samples obtained after PTH removal within 10 minutes of removing all hyperactive parathyroid tissue,
The PTH levels should fall by more than half.
By testing PTH levels before removing the hyperactive parathyroid glands (usually before starting the operation and before tying off the blood supply to the gland) and then again after removal of the abnormal gland the surgeon can determine if there are additional hyperfunctioning glands present.
Although there are different criteria for a successful operation, most surgeons look for at least a 50% drop in the PTH levels in order to consider the patient cured.
False negative is a possibility

42
Q

Parathyroidectomy review

A

Hyperparathyroidism is being recognized more as a result of detection of hypercalcemia
Symptoms in patients are subtle or absent
Parathyroidectomy is a successful treatment
Clinical Presentation of Hyperparathyroidism
“Stones, bones, abdominal groans and psychiatric overtones”

43
Q

What are the complications of thyroid surgery?

A

The most important complications of thyroid surgery result in respiratory distress and include recurrent laryngeal nerve palsy, hypocalcemia, tracheal compression, phrenic nerve injury, and pneumothorax.

Complications with the potential for respiratory distress

  1. Recurrent laryngeal nerve palsy
  2. Hypocalcemia
  3. Tracheal compression
  4. Phrenic nerve injury
  5. Pneumothorax

Complications that do not result in respiratory distress

  1. Hypothyroidism
  2. Thyroid storm
44
Q

What are the intraoperative anesthetic considerations for thyroid surgery?

A
  • Level of difficulty securing airway (assess pre-op & plan)
  • Type of ETT (Nerve monitor, Armored if compressive concerns)
  • Hypovolemia
  • Acute Thyroid Crisis may occur during induction or after
  • The goals of anesthetic management are to avoid hypertension and tachycardia.
  • Medications that stimulate the sympathetic nervous system should be avoided.
  • Muscle relaxants are the best choice to prevent movement during tracheal manipulation. However, they are contraindicated when recurrent laryngeal nerve monitoring is employed. In these cases, opioids, by depression of laryngeal reflexes, help prevent intraoperative patient movement and provide the added benefit of inhibiting coughing on emergence.
  • Careful eye protection for patients with proptosis
  • Tracheomalacia
45
Q

How is regional anesthesia performed for thyroid surgery?

A

The superficial cervical plexus receives contributions from cervical nerve roots 1 through 4 (C1-4). It supplies sensory innervation to the lateral scalp (lesser occipital nerve), pinna (greater auricular nerve), neck (transverse cervical nerve), and upper chest (supraclavicular nerve) (Figure 27-1). The superficial cervical plexus courses subcutaneously at the midlateral border of the sternocleidomastoid muscle. The superficial cervical plexus block is a field block. Bupivacaine or another long-lasting local anesthetic without epinephrine is injected deep to and along the posterior border of the sternocleidomastoid muscle. Approximately 5 to 10 mL of local anesthetic is sufficient.

46
Q

Discuss a typical general anesthetic for parathyroid surgery.

A

+/- NMBA’s specialty ETT if monitor RLN
To avoid patient movement in the absence of muscle relaxants, deep general anesthesia is required with potent inhalation agents, intravenous anesthetics, or combinations of both.
Opioid-based anesthetics depress laryngeal reflexes and minimize intraoperative coughing during surgical manipulations.
Opioid depression of laryngeal reflexes also provides for smooth emergence from anesthesia, with minimal bucking. Coughing tends to increase venous pressure, predisposing to bleeding in the neck. Neck bleeding increases the risks of hematoma and airway obstruction.
PTH levels are frequently analyzed intraoperatively.

47
Q

What are the recognized complications of parathyroid surgery?

A

The most important problems relate to airway patency (similar to thyroid surgery)
recurrent laryngeal nerve damage, hemorrhage, and hypocalcemia. Unilateral recurrent laryngeal nerve injuries cause hoarseness and potentially aspiration. Bilateral recurrent laryngeal nerve damage can produce respiratory obstruction. Patients with partial respiratory obstruction present with stridor. Total airway obstruction produces apnea. Arterial bleeding can drive blood through fascial planes; collect posterior to the membranous trachea; and force the membrane into the airway, decreasing the trachea’s luminal size. Hypocalcemia can produce muscular tetany. This phenomenon is widely recognized in the face and hands. When laryngeal muscles develop tetany, vocal cords close, and the airway becomes obstructed. Following parathyroidectomy, hypocalcemia can occur on the day of surgery or weeks later. Definitive diagnosis of hypocalcemia is made by analyzing blood for ionized calcium concentrations.
Hypocalcemia muscle cramping. Facial nerve irritability is demonstrated by Chvostek’s sign, Carpal irritability is demonstrated with Trousseau’s sign
Circumoral, hand, or foot paresthesias can result. Severe hypocalcemia can also produce coagulopathy, hypotension, psychosis, or seizures

48
Q

How is hypocalcemia treated?

A

Symptomatic or severe hypocalcemia requires treatment with intravenous calcium. Ten mL of calcium chloride provides 273 mg of calcium. Ten mL of calcium gluconate provides 93 mg of calcium. Intravenous administration of 10 mL of calcium chloride or 20 mL of calcium gluconate over 20 minutes is recommended. Parenteral calcium replacement should be monitored with electrocardiograms and blood levels of calcium, potassium, phosphorus, magnesium, and creatinine. Calcium irritates veins, so central administration generally provides greater patient comfort. Calcium is incompatible with bicarbonate. Combining the two produces a precipitate of calcium.

49
Q

What are Recurrent Laryngeal Nerve Injury Estimates which occur during thyroid surgery?

A

It is estimated that the overall incidence of RLN injury during thyroid surgeries ranges 0.3-18.9%.

The incidence of RLN Injuries drops to 1% to 2% with experienced neck surgeons