Anesthesia for Extrathoracic Breast Surgery and Resconstruction Flashcards

1
Q

Describe the Anatomy & Physiology of the Breast

A

The breast overlies:
Pectoralis major
Serratus anterior
External oblique muscles
2nd to 6th ribs (costal cartilages) but the mammary gland is more extensive than the breast and generally extends into the axilla as an “axillary tail”
Breast contains 15–20 lobes
Fat covers the lobes & gives breast size & shape
Lobules fill each lobe
Sacs at the end of lobules produce milk
Ducts deliver milk to the nipple
Retromammary Space: Space between Breast & Deep Fascia
Breast is divided into Quadrants for clinical identification

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2
Q

Explain Arterial Perfusion & Venous drainage of the Breast.

A
Three main arteries supply the breast:
Internal mammary artery
Internal/Lateral thoracic artery
Axillary artery
The veins of the breast correspond with the arteries, draining into the axillary and internal thoracic veins.
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3
Q

What Muscles are Relevant to Breast Surgery?

A
Pectoralis Major
Pectoralis Minor
Serratus Anterior
Latissimus Dorsi
Intercostal Muscles
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4
Q

Describe the Pectoralis Major Muscle.

A

Attachments: The distal attachment of both heads is into the intertubercular sulcus of the humerus.
Clavicular head – originates from the anterior surface of the medial clavicle.
Sternocostal head – originates from the anterior surface of the sternum, the superior six costal cartilages and the aponeurosis of the external oblique muscle.
Function: Adducts and medially rotates the upper limb, and draws the scapula anteroinferiorly. The clavicular head also acts individually to flex the upper limb. Clavicular head allowes flexion of shoulder.
Innervation: Lateral and medial pectoral nerves.

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5
Q

Describe the Pectoralis Minor Muscle.

A

The pectoralis minor lies underneath its larger counterpart muscle, pectoralis major. Both of these muscles form part of the anterior wall of the axilla region.

Attachments: Originates from the 3rd-5th ribs, and inserts into the coracoid process of the scapula.
Function: Stabilizes the scapula by drawing it anteroinferiorly against the thoracic wall.
Innervation: Medial pectoral nerve.

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6
Q

The Serratus Anterior Muscle:

A

The serratus anterior is a muscle that originates on the surface of the 1st to 8th ribs at the side of the chest and inserts along the entire anterior length of the medial border of the scapula.
The serratus anterior acts to pull the scapula forward around the thorax. The muscle is named from Latin: serrare = to saw, referring to the shape, anterior = on the front side of the body.
The function of the serratus anterior muscle is to allow the forward rotation of the arm and to pull the scapula forward and around the rib cage. The scapula is able to move laterally due to the serratus anterior muscle, which is vital for the elevation of the arm. The serratus anterior muscle also allows the upward rotation of the arm, which allows a person to lift items over their head.

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7
Q

The Latissimus Dorsi Musle:

A

The latissimus dorsi muscle is one of the largest muscles in the back. There muscle is divided into two segments, which are configured symmetrically along the backbone.
The muscle is located in the middle of the back, and it is partially covered by the trapezius. It originates along the seventh thoracic vertebra (T7) region of the spine and extends to its insertion point on the humerus.
The muscle also covers the lower tip of the scapula, or shoulder blade. When flexed, the muscle works at extending, adducting and rotating the arm. Because of its size and central location, injury to this muscle can be debilitating.
The latissimus dorsi is responsible for extension, adduction, transverse extension also known as horizontal abduction, flexion from an extended position, and (medial) internal rotation of the shoulder joint.

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8
Q

The Intercostal Muscles:

A

Intercostal muscles are muscle groups that are situated in between the ribs that create and move the chest wall.
The muscles are broken down into three layers, and are primarily used to assist with the breathing process.
The three layers are: external intercostal muscles, internal intercostal muscles, and the innermost intercostal muscles.
These muscles are innervated and supplied with blood by the intercostal nerves, intercostal veins, and intercostal arteries.

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9
Q

The Lymphatic Duct:

A

Lymphatic duct
Drains Right side of head & neck, Right upper limb, Right lung and Thoracic wall, Right side of heart and Right surface of Liver.

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10
Q

The Thoracic Duct:

A

Thoracic duct
Drains 3/4 of the body via the left jugular trunk, left subclavian, left bronchomediastinal, left and right lumbar and intestinal trunks.
Largest Lymphatic Trunk Starts in abdomen lower border T12 (as continuation of cisterna chyli)
Enters post mediastinum through aortic opening of diaphragm (T12)
T5 shifts to left & runs in superior mediastinum
C7 arches laterally then downwards
Ends at angle formed by union of left internal jugular vein & left subclavian vein

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11
Q

Lymphatic Drainage of Upper Limb & Breast:

A

Clinical importance due to its role in the metastasis of breast cancer cells.

3 groups of lymph nodes that receive lymph from breast tissue
axillary nodes (75%),
parasternal nodes (20%)
posterior intercostal nodes (5%)

The skin of the breast also receives lymphatic drainage:
Skin – drains to the axillary, inferior deep cervical & infraclavicular nodes.
Nipple and areola – drains to the subareolar lymphatic plexus.

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12
Q

Sentinel Lymph Node & Intraoperative Lymphatic Mapping:

A

Which lymph node is the sentinel lymph node for dissection?
The 1st Lymph Node downstream from the tumor
The sentinel lymph node is the node most likely to harbor metastatic disease if it is present

Mapping:
Pre-op lymphoscintigraphy - injection of Tc99m sulfur colloid 4 hours prior to surgery
Intra-op gamma probe
Vital blue dye (1% isosulfan blue/Lymphazurin)

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13
Q

Breast Innervation:

A

The breast is innervated by the anterior and lateral cutaneous branches of the 4th to 6th intercostal nerves. These nerves contain both sensory and autonomic nerve fibers (the autonomic fibers regulate smooth muscle and blood vessel tone).
It should be noted that the nerves do not control the secretion of milk. This is regulated by the hormone prolactin, which is secreted from the anterior pituitary gland.

What nerve innervates the latissimus muscle?
Thoracodorsal nerve

What nerve innervates the serratus anterior muscle?
Long thoracic nerve

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14
Q

Respiratory Risk Assessment Prior to Extrathoracic Surgery

Patient Risk Factors:

A
Patient Risk Factors
Age
Chronic Lung Disease
Asthma
Smoking
Obesity
OSA
Pulmonary Hypertension
Heart Failure
General Health Status
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15
Q

Respiratory Risk Assessment Prior to Extrathoracic Surgery

Procedure Risk Factors:

A
Procedure Risk Factors
Surgical Site/Technique: The incidence of pulmonary complication inversely related to distance of incision to diaphragm.
Surgery Duration
Type of Anesthesia
Type of Neuromuscular Blockade (residual block)
 Preoperative Clinical Evaluation
PFT’s
ABG
CXR
Exercise Testing
Pulmonary Risk Incides
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16
Q

Describe Breast Lumpectomy/Partial Mastectomy +/- Needle Localization.

A

Tissue sparing Partial Mastectomy. The mass is removed in addition to surrounding tissue sent for pathology.

Needle Localization Partial Mastectomy is used when clinically unable to palpate mass. It is placed pre-operatively in radiology.

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17
Q

Describe Simple Mastectomy vs. Modified Radical Mastectomy and Radical Mastectomy.

A

Simple or total: removal of entire breast without removal of lymph nodes

Modified Radical Mastectomy: A simple mastectomy with the removal of the lymph nodes under the arm (called an axillary lymph node dissection).

Radical: removal of the entire breast and lymph node dissection and the pectoral (chest wall) muscles under the breast.
This surgery was once very common, but less extensive surgery (such as the modified radical mastectomy) has been found to be just as effective and with fewer side effects, so this surgery is rarely done now.

Other modifiers are:
Skin sparing
Nipple sparing

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18
Q

Where does the long thoracic nerve arise, travel?

What occurs when the long thoracic nerve is injured?

A

The long thoracic nerve arises from the posterior aspect of C5, C6, and often C7 ventral rami. It travels within the scalenus medius muscle. It then runs over the lateral surface of the serratus anterior supplying it with multiple branches

What occurs when the long thoracic nerve is injured?
Long Thoracic Nerve Palsy
Winging of the scapula

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19
Q

Where does the thoracodorsal nerve arise?

What occurs when the thoracodorsal nerve is injured?

A

The thoracodorsal nerve (C6, C7, and C8) arises from the posterior cord. It courses anterior to the latissimus dorsi muscle along with the corresponding vessels and supplies the muscle.
What occurs when the thoracodorsal nerve is injured?
Loss of sensation in axilla
Upper extremity weakness

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20
Q

What are Anesthetic Considerations for Mastectomy Patients?

A

Potential Injury to Nerves if axillary involvement
No muscle relaxants with lymph node dissection
Duration: 1-2 or up to 4 hrs (axillary involvement)
EBL: 150 - 500 mL
Post Mastectomy Pain Syndrome
Preemptive nausea treatment
General Anesthesia
LMA smaller cases
ETT larger cases longer duration, full stomach, aspiration risks.
Regional Anesthesia
Supplemental Local Anesthesia (at end of procedure)
Antiemetics

21
Q

What is Post Mastectomy Pain Syndrome?

Describe the pain of PMPS and how PMPS can show up.

A

A Neuropathic Pain Syndrome
PMPS is defined as chronic pain in breast, axilla and/or chest wall that lasts at least three months after surgery for breast cancer.

This nerve pain can show in a number of ways and may not even start until up to six months after surgery. Usually, PMPS pain is in the underside of the arms or the upper chest, and it can cause shooting or burning pains.
Inter-costo-brachial neuralgia
Dissection of the axilla
Scar Pain (Neuroma)
Occurs 23-68% of patients
22
Q

What is Isosulfan Blue (Lymphazurin) used for?
Describe Side Effecrs of Lymphazruin.
How would you treat anaphylaxis from this medication?

A
Side effects to Isosulfan Blue:
Pseudo hypoxemia
Blue-green urine and/or stool
Pseudo cyanosis ( "Gray lady" syndrome); "Blue hives"
Urticaria
Anaphylaxis
Treat a isosulfan blue dye reaction:
100% O2
Epi 0.01 - 0.5 mg IV or IM
1 -2 L LR
Diphenhydramine 50 - 75 mg IV
Hydrocortisone or Methyl Prednisone
23
Q

What are Breast Surgery Reconstruction Complications?

A
Surgical site Infection
Chronic recurrent breast cellulitis
Seroma
Hematoma
Chronic Pain
Venous Thromboembolism
Incisional Dog-Ears
Breast fibrosis
Associated with Axillary Lymph Node Dissection
Lymphedema
Nerve injury (Long thoracic, Thoracodorsal)
Chyle leak (Rare)
24
Q

What are 2 reasons chemotherapy is chosen for treatment?

A

Debulking large tumors

Treat patient’s with aggressive metastatic disease and who are ER/PR negative

25
Q

How long after radiation can a patient have surgery?

A

6-12 months, time enough for the damaged tissue to heal

26
Q

What is a side effect of the chemo drug Bleomycin?

Pulmonary toxicity

A

What is a side effect of the chemo drug Bleomycin?

27
Q

What is a side effect of the chemo drug Doxorubicin (Adriamycin)?

A

Cardiomyopathy

28
Q

What are complications of a TRAM flap?

A

Atelectasis
DVT
Flap failure
Abdominal hernia & muscle weakness (mesh used to prevent)

What makes the ideal candidate for a TRAM flap?
Overall healthy (Increased morbidities with Increased ASA status)
non-smoker
not obese

29
Q

What is a Pedicled TRAM Flap?

A

TRAM (transverse flap of the rectus abdominis muscle) is based on one of the muscles of the abdomen.
In this procedure, skin, fat and muscle are moved from the abdomen to recreate the breast.
In some cases, a BARs (bony anchor reinforcement) TRAM flap is performed. Pioneered by the physicians at The Institute for Advanced Reconstruction, this innovative technique uses reinforced mesh, which is placed on the abdominal wall at the time of reconstruction, reducing the rate of post-operative hernia.

30
Q

What is a Latissimus Dorsi Flap?

A

In this procedure, skin, fat and muscle are moved from the back to recreate the breast.
This may be combined with a tissue expander and/or breast implant.

31
Q

Latissimus Dorsi Flap Anesthetic Care:

What is a side effect of a LD flap?

A

Pedicled or Free Flap?
Duration: 3-6 hrs
EBL: 200 - 400 mL
Position changes necessary
When is a LD flap chosen over a TRAM flap?
Pt’s with a history of abdominal surgery or a radical mastectomy

What is a side effect of a LD flap?
Muscle weakness with climbing or swinging

32
Q

Free Flap

How is the anastomosis done?

Describe Ischemia time and implications to flap.

Describe post anastamosis inset, care and assessment.

A

Complete the anastomosis using either a vascular coupler, or sew it by hand. The coupler has demonstrated its usefulness, especially for venous anastomoses, in improving patency and decreasing operative time.
The tolerated flap ischemia times depend upon the composition of the tissues being transferred. In general, perforator flaps tolerate longer periods of ischemia because no muscle is involved. Ischemia times of up to 4 hours for a perforator flap may be well tolerated. Musculocutaneous flaps, on the other hand, do not tolerate prolonged ischemia times because of the metabolic requirements of the muscle. In general, 2-3 hours of ischemia is the maximum time tolerated.
Following completion of the anastomoses, the flap must be properly inset. Inspect the vascular pedicle for kinks, twists, and compression and to ensure that no tension is present across the anastomosis. Inspect the distal aspect of the flap for arterial and venous bleeding. Use a Doppler unit to assess arterial and venous flow through the pedicle and in the flap. Finally, recheck the vascular pedicle to ensure that there is a gentle, nontwisting course for the vessels before completing the final suturing of the flap, especially if the patient’s position has been changed.

33
Q

When is a free flap done?

What are some donor sites for a free flap?

A

When is a free flap done?
If a previous surgery prevents pedicled flap
If superior epigastric vessels are disrupted
If severe radiation damage

What are some donor sites for a free flap?
Gluteus, thigh, latissimus dorsi

34
Q

Describe Primary Ischemia for Free Flap surgery.

A

Primary Ischemia-Blood flow ceases during flap transfer
Induces anaerobic cellular metabolism
Increased lactate (decreased intracellular pH -increased Ca+ & pro-inflammatory mediator levels)
Severity r/t duration of ischemic time
Oxygen consumption by skin 5x lower than muscle (TRAM more sensitive because they have muscle)

35
Q

Describe Reperfusion and Anesthetic Care of Free Flap Surgical Procedure.

A

Reperfusion-Vessel unclamping restoring perfusion
Need Good Blood Flow (Hagen-Pouiselle equation)
Prevent hypothermia
Maintain oxygen carrying capacity (Hg/Hct)
Goal-directed fluid therapy to maintain high cardiac output (reduced CO induces vasoconstriction mediated by SNS, renin-angiotensin aldosterone and baroreceptor reflex)
Vasoactive drugs (avoid vasodilators-steal syndrome) (Vasoconstrictor-fear of systemic vasoconstriction leading to decreased flap perfusion—few studies supporting either side)
Anticoagulation-DVT risk prolonged surgery SQ heparin & inflating leggings
Smooth emergence-Prevent increase venous pressure and reduce flap flow
Low dose remifentanil
Consider deep extubation
Exchange ETT for LMA

36
Q

What is a Free Flap Reconstruction Surgery?

Why is it called microsurgery?

A

When the blood supply to any of the fat/muscle/skin flap is separated & reattached, it is called a free flap.
This is a microsurgery: A process in which small blood vessels are reattached under a microscope either hand sewn or using a coupler. Instruments, vessels and sutures are very tiny.

37
Q

What is a DIEP flap?

A
The DIEP (deep inferior epigastric artery perforator-IMA) is the blood supply to the abdominal skin and fat.
In this procedure, skin and fat are moved from the abdomen to recreate the breast.
This procedure, which spares the abdominal wall muscle, reduces the rate of postoperative hernia.
38
Q

What is a TRAM flap?

A

TRAM (transverse flap of the rectus abdominis muscle) is based on one of the muscles of the abdomen.
Skin, fat and muscle are moved from the abdomen to recreate the breast.

39
Q

What are the Two types of autologous breast reconstruction?

What is the difference between the 2?

A

Two Types Autologous Reconsruction
Pedicle
Free

Difference:

  1. Pedicle flaps - native circulation provides flap
    a. TRAM flap (Transverse rectus abdominus myocutaneous)
    b. Latissimus dorsi flap
  2. Free flap - disrupts native circulation
40
Q

When can a tissue expander/implant not be used?
Skin is too thin and/or irradiated

What are some complication with an implant/tissue expander?

A

Skin is too thin and/or irradiated

complication with an implant/tissue expander:
Capsular contractures
Infection

41
Q

Where are the Implant Access Incisions for Breast Augmentation?

What are the Implant Placement Options?

A

Implant Access Incisions:
Inframammary
Peri-areolar
Axillary

Implant Placement Options
Supra-Pectoral
Sub-Pectoral

42
Q

Describe Anesthetic Managment for Breast Reconstruction.

A

Warming measures important, ↓ temp = vasoconstriction
Avoid vasopressors
Monitor BP closely in free flap cases to maintain perfusion
Blood loss is oozing in nature and is hard to estimate
May be necessary to sit patient up during the surgery
Verify position after adjustments and throughout case
Secure arms with padding
What is anesthetic management of TRAM flap?
No N2O
Duration: 3-6 hrs
Sitting to Close incision with flexed waist, bent knees to reduce incisional tension

43
Q

PONV & Breast Surgery:

A
Patient characteristics that ↑ the risk of PONV
female gender (especially if pregnant or menstruating)
prior history of PONV
history of motion sickness
being a nonsmoker
Other Characteristics which ↑ PONV
Breast procedures
Surgical duration >30 minutes 
25%–30% of surgical patients experience PONV within 24 hours
PONV may contribute to 
high levels of patient discomfort
delayed PACU discharge
increased need for nursing care
potential hospital admission
44
Q

What are some Strategies to Reduce PONV in the Anesthetic Management of patients undergoing Breast Surgery?

A

Strategies to reduce PONV
Propofol for induction and maintenance of general anesthesia (TIVA)
Avoidance of nitrous oxide & volatile anesthetics
Avoidance or minimization of intraoperative and postoperative opioids
Avoidance or minimization of neostigmine given for muscle relaxant reversal
Administration of adequate hydration
Prophylactic administration of 5-HT3 antagonists & other antiemetic’s

45
Q

Regional Options for Breast Surgery Include________.

A
Local Infiltration (calculate dose for each patient)
Epidural
Paravertebral Block
PECs Block
Serratus Plane Block
46
Q

What are Pectoral Plane Blocks?

A

Pecs blocks are applied in the pectoral and axillary regions, with the muscles in both regions innervated by the brachial plexus.
The pectoral region overlies the pectoralis major muscle and is limited by the axillary, mammary, and inframammary regions
The axillary region is lateral to the pectoral region and consists of the area of the upper chest that surrounds the axilla. In both regions, there are muscles, nerves, and vessels within the fascial layers
In the pectoral region, there are four muscles relevant to Pecs blocks: the pectoralis major, pectoralis minor, serratus anterior, and subclavius muscles. The pectoralis major and minor muscles are innervated by the lateral and medial pectoral nerves; the serratus anterior is innervated by the long thoracic nerve (C5, C6, and C7); and the subclavius is innervated by the upper trunk of the brachial plexus (C5 and C6).

47
Q

Describe the Serratus Plane Block.

A

The serratus plane block is performed in the axillary region, at a more lateral and posterior location than the Pecs I and II blocks.
At the axillary fossa, the intercostobrachialis nerve, lateral cutaneous branches of the intercostal nerves (T3–T9), long thoracic nerve, and thoracodorsal nerve are located in a compartment between the serratus anterior and the latissimus dorsi muscles, between the posterior and midaxillary lines.
The two main anatomical landmarks are the latissimus dorsi and the serratus anterior muscles. The thoracodorsal artery runs in the fascial plane between the two. The ribs, pleura, and intercostal muscles can also be seen during the procedure.

48
Q

Describe Thoracic Paravertebral Block.

A

Thoracic paravertebral block (PVB) is a well-established technique for perioperative analgesia in patients having thoracic, chest wall, or breast surgery or for pain management with rib fractures.
Ultrasound guidance can be used to help identify the paravertebral space (PVS) and needle placement, and to monitor the spread of the local anesthetic. Importantly, interference of the closely related osseous structures with ultrasound imaging and the proximity of the highly vulnerable neuraxial structures make it imperative that all well-described technique precautions are exercised, regardless of the ultrasound imaging.
Thoracic PVB is accomplished by an injection of local anaesthetic into the PVS, which contains thoracic spinal nerves with their branches, as well as the sympathetic trunk. Anatomically, the PVS is a wedge-shaped area positioned between the heads and necks of the ribs