Anemias Flashcards
What is anemia?
A blood disorder where there is a deficiency of erythrocytes or hemoglobin.
What are the three basic problems causing anemia?
1) defective erythropoiesis (defective production)
2) excessive hemolysis (premature or abnormal destruction)
3) excessive loss (ex. hemorrhage)
What is the pathophysiology or anemia?
- abnormal RBC number, structure or function
- leads to decreased oxygen carrying capacity
- leads to hypoxia
What are the manifestations of moderate anemia?
- dyspnea
- palpitations
- chronic fatigue
What are the manifestations of severe anemia?
- chronic exhaustion
- palpitations
- profound weakness
- dizziness
- headache
- sensitivity to cold (metabolism makes heat)
How many erythrocytes do we make in a minute?
180 million
Do RBCs transport nutrients?
no, they transport oxygen
What are the components of hemoglobin?
- globin (protein)
- heme (x4)
- iron (x4)
What are the different types of anemia?
- iron deficiency
- vitamin B12 and folic acid deficiency
- pernicious anemia
- aplastic anemia
- hemolytic anemia
- hemorrhagic anemia
- sickle cell anemia
Where does oxygen bind to hemoglobin?
It binds to the iron.
What causes iron deficiency anemia?
inadequate intake of iron or excessive loss of iron, the type of anemia is prevalent in 3rd world countries where there is a lack of meat in the diet
How do you treat iron deficiency anemia?
- treat the underlying cause
- give iron PO for 4-6 months
Why isn’t a CBC the test of choice to detect iron deficiency anemia?
because it tells you about the cells and not their iron content
What role do vitamin B12 and folic acid have in hematopoeisis?
They are required for DNA synthesis and cell division. If there is a deficiency there will be abnormal production of erythrocytes, leukocytes and thrombocytes.
How are vitamin B12 and folic acid deficiency treated?
- give vitamin B12 (250 micrograms)
- give folic acid