Anemia Review

Question 1

What is the most common cause of GI bleeds?

Answer 1

Ulcers and NSAIDS

Question 2

Who gets iron supplements w/o labs??

Answer 2

pregnant, young girls with menorrhagia, vegetarians

Question 3

Occult bleeding is usually the result of ??? examples.

Answer 3

• GI blood loss
• -upper GI: peptic ulcer disease, esophageal varices, gastritis
• -Lowe GI: hemorrhoids, diverticula, colorectal cancer, inflammatory bowel disease

Question 4

What is the best lab indicator of iron deficiency?

Answer 4

low serum ferritin levels

*Gold standard for dx in most patients

Question 5

Microcytic Anemia in the context of low or normal RDW is often what type of anemia?

Microcytic anemia in the context of high RDQ is often what type of anemia?

Answer 5

• Anemia of chronic disease or thalassemis

- iron deficiency

Question 6

Chronic inflammatory diseases are indicators of which type of anemia?

What is low in almost all cases?

Answer 6

Anemia of chronic disease

-EPO & Serum Iron

Question 7

What are some diseases associated with anemia of chronic disease?

Answer 7

• RA
• Lupus
• HIV
• TB
• Leukemia

Question 8

What is the main etiology of Pernicious Anemia?

Answer 8

autoimmune

Question 9

Absorption of B12 depends upon 5 factors; anything that interferes with any of these can lead to deficiency

Answer 9

• adequate dietary intake
• acid-pepsin in stomach
• pancreatic proteases
• gastric secretion of a functional intrinsic factor
• ileum w/ functioning Cobalamin-intrinsic factor receptors