anemia of iron/heme metabolism and abnormal nuclear development

Question 1

iron deficiency anemia

what is the blood picture
what are the abnormal cells found

Answer 1

microcytic hypochromic
ovalocytes

Question 2

anemia of chronic disease

what’s the blood picture

Answer 2

normocytic normochromic

Question 3

sideroblastic anemia

Question 4

lead poisoning

Question 5

porphyria

Answer 5

• decreased hemoglobin result
• defects in synthesis of protoporphyrin due to abnormal protoporphyrin precursors

Question 6

iron overload

Answer 6

free iron in ferrous state initiates the generation of superoxide and other free radical that damages the membrane lipids.

Question 7

most common form of anemia

Answer 7

IDA

Question 8

most common form of anemia in hospitalized patients

Answer 8

ACD

Question 9

2nd most common form of anemia

Answer 9

ACD

Question 10

idiopathic sideroblastic anemia

Answer 10

• aka refractory anemia with ringed sideroblasts and idiopathic acquire SDA
• associated with decreased ALA synthase

Question 11

secondary sideroblastic anemia

Answer 11

follows after exposure to certain drugs and toxins

Question 12

screening test for porphyria

Answer 12

watson-schwartz test

Question 13

example of iron-chelating drugs

Answer 13

desferrioxamine - iron is excreted in the urine

Question 14

diagnostic test for pernicious anemia

Answer 14

schilling’s test

Question 15

failure to split vitamin b12 for food

Answer 15

hypochloridia

Question 16

diagnostic test for megaloblastic anemia

Answer 16

schilling’s test

Question 17

orotic aciduria

Answer 17

disorders of pyrimidine metabolism
with physical retardation

Question 18

lesh-nyhan syndrome

Answer 18

deficiency in xanthan guanine phosphoribosyl transferase