Andrews Chapter 8: CTD

Question 1

Bullous Lupus vs EBA

Answer 1

both collagen VII anti; but bullous lupus responds to dapsone. Also HLA-DR2 assox

Question 2

Chronic LE

Answer 2

DLE,
hypertrophic LE
LE-LP overlap
chilblain lupus (nose, ears, fingers, heel/calf)
tumid lupus (lots of mucin, can look like reticular erythematous mucinosis)
lupus panniculitis (vs pannic-like CTCL)

Question 3

Childhood DLE

Answer 3

More like to have SLE, less photosensitivity

Question 4

Drug that causes SLE, and drug that causes drug-induced SLE

Answer 4

etanercept and penicillamine; hydralazine, procainamide, minocycline, sulfonamide, PCN, isoniazid, anticonvulsant

Question 5

Sneddon syndrome

Answer 5

livedoid vasculopathy with CNS sx - from hyalinizing vasculopathy

Question 6

ANA in LE

Answer 6

peripheral = renal; particulate = SCLE; homogenous = histone

Question 7

Drug that can cause DM like eruption

Answer 7

Hydroxyurea

Question 8

acrodermatitis chronica atrophicans

Answer 8

progressive skin fibrosis, late stage lyme disease

Question 9

Scleroderma has loss of CD34 dermal cells, but this has increased CD34 cells

Answer 9

Nephrogenic systemic fibrosis

Question 10

Interstitial granulomatous dermatitis -describe clinical findings

Answer 10

rope sign - cord from upper back to axille; round to oval erythematous or violaceous plaques on flanks, axillae, inner thighs, abdomen, may be a/w autoimmune dz; vs GA - lesions on hands/feet/back

Question 11

Palisaded neutrophilic granulomatous dermatitis, associated with what?

Answer 11

associated with RA, SLE

Question 12

Blau syndrome

Answer 12

granulomatous disease with symmetric arthritis and uveitis; CARDS15/NOD2 mutation; early onset sarcoidosis?

Question 13

linear for of atrophoderma of pasini and pierni

Answer 13

atrophoderma of moulin