Anatomy Lymphoreticular system

Question 1

name the cells involved in the immune system

6

Answer 1

-B cells = humoral immunity
-T cells= cell mediated response ( T helper, killer, suppressor )
supportive cells :
1.reticular cells = type 3 collagen ( home for immune cells to live in )
2. Epithelioreticular cells found in THYMUS =hormones and structural support
3. Dendritic cells = APCs
4. Macrophages= APCs + phagocytosis !

Question 2

what are the primary tissues ? what do they do ?

2

Answer 2

-lymphocytes are produced in primary tissues :
1- Bone marrow (B cells)
2-Thymus (T cells)

Question 3

what are the secondary organs? what do they do?
(4)
Soohyun
likes
talking 
to
Myungsoo

Answer 3

-spleen , lymph nodes , thymus , tonsils , Mucosa associated lymphoid tissue , gut associated lymphoid tissue
= they meet antigens for the first time here= undergo Antigen -dependant Activation to battle against specific regions

Question 4

histology of the lymph nodes

outer cortex =cells ? 5 BSRDM
inner cortex ?1
medulla?4
function ?1

Answer 4

lymph nodes = remove harmful substances from the Body
-OUTER coretx = lymphatic follicles of B-cells , purple circle = lymphatic follicle , subcapuscular sinus , reticular fibres ( collages type 3) , dendritic cells, macrophages
-Inner cortex = mostly T cells
-Medulla = paler in colour in centre :
Trabeculae = supporting rods
Medullary chords and sinuses = supports the lymph node

Question 5

histology of the tonsils, how many are there ?
describe
epithelium
(4)

PPLT

Answer 5

4 x tonsil

1) Pharyngeal tonsil =PSCC( behind nasal cavity)
2) Palatine tonsil (L+R in your mouth =normal tonsils) =stratified squamous non keratinising epithelium
3) Lingual tonsil =stratified squamous non keratinising epithelium = root of tongue
4) Tubal tonsil =PSCC= beneath the eustachian tube

Question 6

histology of the spleen
(6)
Its like black pink

Answer 6

• filters blood
• kills old RBC but also makes new RBS in fetal development before the bone marrow was formed

1) RED PULP = rich in BVs , blood sinusoids (microscopic blood channels= VVVVV LEAKY ALLOW FOR BLOOD FILTRATION , and exposure to macrophages in chords), supports the RBC , macrophages , dendrites cells and lymphocytes and
Billroths chords =fibrils + CT + monocytes and macrophages
red pulp function is to filter blood for any antigens , micro-organism and old RBC

2) White pulp
- WBC s , has a central artery = surrounded by periarterial lymphoid sheath = with T-CELLS = PALS ?????
- lymphoid follicles = B cells
main function is also to filter blood

Question 7

histology if the thymus
thymic school !
(6)
role of thymus 
T cell journey 
specialist features
Hogwarts teacher !

Answer 7

ROLE : maturation of t-
CELLS = in cortex
cells and journey of T cells:

1) naive T-cells , as they enter the medulla they are put through testing to identify own antigens = macrophages phagocytose the ones which don’t pass testing !
Medulla = Light staining cells = mature T-cells

2)Hassalls corpuscles= which contain epithelioreticular cells which produce keratohyalin and make hormones to mature the T-cells

the blood thymus barrier protects naive T cells from the foreign antigens before they’re ready !

Question 8

where it the mucosa associated lymphoid tissue and gut associated lymphoid tissue found ?

location in body + location in epithelium
what do they do

(6)

Answer 8

1- near most epithelial surfaces : GI tracts, breast , lung , salivary glands , nasopharynx , gut

2- located in lamina propria= can see which antigens are crossing the epithelium = monitor and initiate immune response

3- Spherical arrangements of lymphoid follicles = monitor the CT for antigens etc