Anatomy Exam 4 Flashcards
What are the functions of the Urinary system
Regulation of blood ionic composition Regulation of pH, osmolarity, glucose Regulation of blood volume Regulation of blood pressure Release of erythropoietin and calcitriol Excretion of wastes and foreign substances
What ions do the urinary system/Kidney regulates
Na+, K+, Ca+2, Cl- and phosphate ions
How is the blood volume regulated
Conserving or eliminating water
How is the blood pressure regulated
Secreting the enzyme renin
Adjusting renal resistance
What are the 3 regions of the kidneys
Cortex, Medulla, and Pelvis
What is the renal cortex of the kidneys
Superficial Layer
What is the renal blood supply flow
Abdominal Aorta Renal Artery Segmental Artery Interlobar Artery Arcuate artery Cortico radial artery Afferent arteriole Glomerular Capillaries Efferent Arteriole Cortico Radial Vein Arcuate Vein Interlobar Vein Segmental Vein Renal Vein Inferior Vena Ceva
What is the renal medulla
Inferior to the Renal Cortex contains medullary/renal pyramids
What are the organs of the Urinary system
Kidneys
Ureters
Urinary Bladder
Urethra
What is the renal cortex
Superficial layer of the kidney
What are the renal columns
Inward extension of cortical tissues that separates the renal medulla
How does the urine go from the kidneys to the ureter
The Minor Calyces is collected from the papillary ducts of the renal papilla.
Urine goes from the minor Calyces to the major Calyces to the renal pelvis and finally to the Ureter
What is contained in the renal pyramids
Parallel bundles of microscopic urine collecting tubules and capillaries
What kind of muscles is found in the calyces, renal pelvis and ureter
Smooth Muscle
What is the path of blood supply in the kindneys
Aorta Renal Artery Segmental Artery Interlobar Artery Arcuate Artery Cortical radiate artery Afferent arteriole Glomerulus (capillaries) Efferent Arteriole Peritubular capillaries/Vasa recta Cortical radiate vein Arcuate vein Interlobar vein Renal Vein Inferior Vena Ceva
What are inside the renal corpuscle
Consist of capillaries called the glomerulus inside the glomerular capsule/Bowman’s capsule
Describe the Glomerulus
Fenestrated capillaries to allow solute rich protein free filtrate from the blood to the capillaries to make urine.
The capillaries vasoconstriction and vasodilation controls blood pressure
Where are Vasa recta and the peritubular capillaries found
The Vasa recta is part of the juxtamedullary nephron
The Peritubular capillaries are found in the cortical nephron
What does the Vasa Recta do
Supplies nutrients to medulla without disrupting its osmolarity form
What does the peritubular capillaries do
Carry away reabsorbed substances from filtrate
What is the renal corpuscle
Site of plasma filtration
Contains the Glomerulus and bowman
What does the urinary system
Filtration, tubular reabsorption, tubular secretion
What does the renal tubule do
Transports the filtrate from renal corpuscle
Contains:
Proximal convulated tubule
Loop of henle dips down into renal medulla
What are the 3 parts of the loop of henle
descending limbs, thin ascending limb and thick ascending limb
What is tubular reabsorption
Water and useful substances are reaborbed into the blood
What is the tubular secretion
Waste removed from the blood and secreted into urine
Efferent tubule gives rise to what
Pertitubular capillaries and Vasa recta
Juxtamedullary Nephron
15-20% of nephrons
Creates concentrated urine
Cortical Nephron
80-85% of nephrons
Lie mainly in cortex
What does podocytes do
Cover capillaries to form visceral layer
Where does the glomerular capillaries arise from
Afferent arteriole
What does the pedicel attach to
Podocytes
Where is the Macula Densa cell found
Distal convoluted Tube
Where is the juxtaglomerular cell found
Afferent arteriole
What are juxtagloerular cells
modified muscle cells
What is the percent of nephron dysfunction
25%
What is rate of excretion
Rate of filtration + rate of secretion - Reabsorption
What are the 3 basic process of nephrons and collecting ducts
Glomerular Filtration
Tubular reabsorption
Tubular Secretion
Glomerular capillary BP is high due to
Small size of efferent arteriole
What is the Net Filtration pressure (NFP)
Total pressure that promotes filtration
What is normal Net filtration pressure
10mmHg
What are the effects of Epinephrine and norepinephrine (NE) on BP
Increase
What are some variable affects of Epinephrine and Norephinephrine (NE)
Increase Cardiac Output ( HR and Contractility)
Increase Peripheral resistance ( Vasoconstriction)
Where is the site of action of Ephinephrine and Norepinephrine (NE)
Heart (beta receptors)
Arterioles (alpha receptors)
What are the effects of Angiotensin II
Increase BP
What are some variable affects of Angiotensin II
Increase peripheral resistance (Vasoconstriction)
Where is the site of action of Angiotensin II
Arterioles
What are the effects of Atrial Natriuretic peptide (ANP)
Decrease BP
What are some variable affects of Atrial Natriuretic peptide (ANP)
Decrease peripheral resistance (Vasodilation)
Where is the site of action of Atrial Natriuretic peptide (ANP)
Arterioles
What are the effects of Antidiuretic Hormone (ADH)
Increase effects of BP
What are some variable affects of Antidiuretic hormone (ADH)
Increase peripheral resistance (vasoconstriction)
Increase Blood volume (decrease water loss)
Where is the site of action of Antidiuretic Hormone (ADH)
Arterioles
Kidney Tubule Cells
Where is the site of action of Aldosterone
Kidney Tubule Cells
What are the effects of Aldosterone
Increase BP
What are some variable effects of Aldosterone
Increase blood volume (decrease salt and water loss)
reabsorption of Na+ and K+ excretion
What are the two types of water reabsorption
Obligatory and Facultative
What kind of water reabsorption does Aldosterone follow
Obligatory Osmosis
What kind of water reabsorption does ADH follow
Facultative Osmosis
Nephrons are mostly found in the
Cortical Nephron 80-85%
Histology: Proximal convoluted tububle
Simple Cuboidal with microvilli
Histology: Descending limb of loop of Henle
Simple squamous
Histology: Ascending Limb of loop of Henle
Simple cuboidal to low columnar
Histology: Distal convoluted Tubule
Simple cuboidal composed of principal and intercalated cells which have microvilli
What is the Macula Densa
Detects NA+ saturation levels
What is the Glomerular Filtration Rate in Males and Females
Male 125 mL/min
Female 105mL/ min
What is important of the Glomerular Blood Hydrostatic Pressure
Promotes Filtration
What are the mechanisms that regulate Glomerular Filtration Rate
Renal Autoregulation
Neural Regulation
Hormonal Regulation
What happens if the Glomerular Filtration Rate is to high
Increase speed of fluid through nephron
Unable to reabsorb substances into the urine
What happens if the Glomerular Filtration is to low
Decrease speed of fluid passage through nephron
Not enough waste products removed from the body
At what mmHg does the Glomerular blood hydrostatic pressure prevents filtration
45mmHg
What is normal GBHP
55mm
What organ secretes Renin
Kidneys
What organ secretes Angiotensinogen
Liver
How is Angiotensin I created
Renin is sent to the Liver and coverts Angiotensinogen into Angiotensin I
How is Angitotensin II
Angiotensin I goes to lung and ACE breaks Angiotensin I into Angiotensin II
What organ secretes Angiotensin Converting Enzyme
Lungs
Where does the Angiotensin II do
Goes to Adrenal Cortex to release Aldosterone
Posterior Pituitary to increase ADH
Goes to Aterioles to vasoconstrict
Goes to hypothalamus to increase blood volume
What organ release Aldosterone
Adrenal Cortex
What does aldosterone do
Increase Na reabsorption by kidneys to assist with increase water reabsorption to increase blood volume
Increase secretion of K+ and H+
What does hormone ADH do
Increase water reabosrption by kidneys
Where does the largest amount of reabsorbtion occur
In the proximal convulated tubule
What is secreted in the Proximal Convulated Tubule
Ammonia (NH3+) and NH4+
What are the 3 layers in wall of the Ureters
Mucosa
Muscularis
Adventitia