Anatomy Exam 1 Flashcards
Cardiovascular system Blood
What are the functions of blood
transporting substance, regulating blood levels of particular substances, and protecting the body
What are the transport functions of blood
Delivering oxygen from the lungs and nutrients from digest tract to body of cells
Transport metabolic waste products
Transporting Hormones
What re the Regulatory functions of the blood
Maintain appropriate body temp- absorb and distribute heat throughout body
Maintain Normal pH - acts as alkaline reserve of bicarbonate ions
Maintain adequate fluid volume
What are the protective functions of the blood
Prevents blood loss
Preventing infection- contain leukocytes, antibodies, and complement proteins
What is blood consist of
Plasma 55%
Erythrocytes 45%
Buffy Coat (contains Leukocytes >1% and platelets
Blood is what type of tissue and consist of what
Connective tissue
Consist of suspended formed elements (leukocytes and Erythrocytes) in plasma
What is dissolved in blood and what is it used for
Dissolved Fibrous
Fibrin strands used for blood clotting
What is the hematocrit percent
Percent of Erythrocytes from the total volume
Normal is 45% Average 47%
Male 40-54%
Female 37-47%
Characteristics of blood
Blood is sticky, opaque fluid
Slightly Alkaline pH 7.4-7.5
More dense and vicious then water
When number of red blood cells increase normal range
blood becomes more vicious and flows more slowly
When number of red blood decrease normal range blood becomes less vicious and fast
What is plasma made out of
90% water Electrolytes- most abundant Nutrients gases hormones waste and products of cells activities proteins inorganic ions
What are the formed elements
Erythrocytes (RBCs)
Leukocytes (WBCs)
Platelets
What are Erythrocytes
RBCs
Mature ones are anucleate (no nucleus) and organelles
Contains hemoglobin (Hb)
What is hemoglobin
bags that performs gas transportation in RBCs
Where does Erythrocytes/RBCs have gas exchange
at the capillaries (lungs and other sites)
Why are Erythrocytes/RBCs concave
To increase surface area for gas exchange, due to cytoplasm close to surface
How much hemoglobin does Erythrocytes/RBCs contain
97%
Why are Erythrocytes good for carrying oxygen
No mitochondria, no use of O2. Uses anaerobic mechanism to create ATP
How much hemoglobin do humans have
Males 13-18 g per/ 100 ml
Females 12-16 g per 100ml
What is hemoglobin made of
Heme - red pigment
Globin- protein
Iron (Fe) - in the middle
What is Globin consist of
2 Alpha
2 Beta
All bind with heme
What is the mechanism of oxygen loading
O2 in the lungs attach to the Erythrocytes via Fe becomes oxyhemoglobin
Color - Ruby Red
What is the mechanism of oxygen unloading
Goes to tissue O2 detaches from Fe
Deoxyhemoglobin
Where does the CO2 attach on the erythrocytes
On the globin protein
What is the name of blood formation
hematopoiesis
Where does blood formation happen
Adult-In Red bone marrow, in the axial skeleton and sternum, ribs, pelvis , proximal epiphyses of the humerus and femur
Embryo- Yolk Sac, liver, spleen, thymus, lymph nodes and red bone marrow
What is the name of Erythrocyte production
Erythropoiesis
In Erythropoiesis, what is the name of the stem cell
Myeloid Stem Cell a descendant of Hematopoietic stem cell
What does Proerythroblast become
Basophilic
What are the two stem cells that differentiates from the pluripotent stem cell
Myeloid or lymphoid stem cell
What is a unique characteristic of reticulocyte
No nucleus but has clumped ribosomes.
How much does reticulocytes account for in the blood
1-2%
What does high amounts of reticulocytes mean
abnormal amounts of erthrocyte formation
What does Erythropoietin (EPO) do
Stimulates the formation of erythrocytes
What is Erythropoietin
glycoprotein hormone
Where is Erythropoietin made
Mostly in the kidneys then in the liver
What triggers synthesis of Erythropoietin
Decrease blood oxygen levels
What drops in normal blood oxygen can result from
Reduced RBC due to hemorrhage or excessive RBC destruction
Insufficient hemoglobin per RBC (as in iron deficiency)
Reduced availability of oxygen (i.e high altitude or during pneumonia)
What controls the rate of erythropoiesis
Ability to transport oxygen
What are other factors needed for erythropoiesis
Nutrients - amino acids, lipids and carbohydrates
Two B- Complex vitamins- Vitamin B 12 and folic acid are necessary for normal DNA synthesis
Iron
What is the life span of RBCs
120 days
What are antigens and where are they found
Found on the RBC plasma membrane.
They are highly specific molecular markers.
There job is to perceives foreign objects and creates an immune response
What are medical uses of Erythropoietin
Used to simulate RBC production in end stage kidney disease
Characteristic of Erythrocytes (RBCs)
Biconcave disk
8 microns in diameter
No nucleus or oranelles
What is the normal Erythrocytes (RBCs) count
Male 5.4 million/drop
Female 4.8 million/drop
How much new RBCs enter the circulation
2 million/second
What does the globin protein made of
4 polypeptide chains
Globin protein connects what
1 heme pigment connected to polypeptide chain
heme contains what
Iron Ion Fe2+
Heme can combine with what
Oxygen molecule
What are Leukocytes
White blood cells
What is it called when Leukocyte count >11,000
Leukocytosis
What does it mean when Leukocyte count >11,000
Body fighting an infection, can be from exercise, anesthesia or surgery
What leukocytes are considered granular
Neutrophils, Eosinophils, basophils
What leukocytes are considered Agranulocytes
Monocytes or Lymphocytes
How much does leukocytes account for in total blood volume
1%
Where is the majority of leukocytes
lymphatic fluid, skin, lungs, lymphnodes and spleen
What is Diapedesis
When Leukocytes slip out of the capillary blood vessels
What are characteristics of granular leukocytes
Large, short lived vs RBCs, have multiple nucleus (2-5) connected by thin nuclear strands. Diameter 10-12 cells , Granules are fine and pale liliac
What is the most abundant leukocytes
Neutrophils
How much WBC are there in a drop of blood
5000-10,000 cells
Due to neutrophils having nuclear variability, what is another name
polymorphonuclear leukocytes
Where are neutrophils attracted to
Sites of inflammation and active sites of phagocytosis
What is it called when leukocyte count is low
Leukopenia
What is a cause of low leukocyte count
radiation, shock or chemotherapy
What are characteristics of Esoinophils
Large (10-12 Diameters), Granules are uniform sized,
How much Eosinophils account for in Leukocytes
2%-4%
What are characteristics of granular leukocytes
Large, short lived vs RBCs, have multiple nucleus (2-5) connected by thin nuclear strands.
What is the most abundant granular leukocyte
Neutrophils (50%-70%)
How many nucleus does older granulocytes contain
usually >3
Due to neutrophils having nuclea, what is another name
polymmorphnucle
What are neutrophils attracted to and what does it attack
Sites of inflammation and active sites of phagocytosis.
Attacks bacteria and some fungi
What are the characteristics of Basophils
Large ( Diameter 8-10 microns), Nucleus is U or S shaped and bilobed nuclei
What does Basophils’ granules contain
Histamines to vasodilate
What type of leukocyte are Eosinophils
Granular and polymorphonuclear
What does the Eosinophils enzymes do not “digest”
bacteria
What is the importance of Eosinophils
Fight parasites
Where are Eosinophils found
Loose connective tissue
How much basophils account for in Leukocytes
0.5%-1% (rarest)
What do B lymphocytes (B cells) do
give rise to plasma cells, which produce antibodies (immunoglobulins)
What are the characteristics of basophils
Large ( Diameter 8-10 microns),
What are characteristics of monocytes
Largest ( 12-20 microns), Contains a kidney shaped or U shaped nucleus.
What are monocytes “job”
Turns into macrophages to fight virus, certain bacteria, and chronic infections
How much does lymphocytes account for in leukocytes
25% or more
What are characteristics of lymphotcytes
Dark, oval to round nucleus, Can be small (6-9 microns) to Large ( 10-14 microns), increase during viral infections
Where are majority of lymphocytes found
In lymphoid tissues
What are characteristics of platelets
Disc-shaped, 2-4 microns fragments, no nucleus ( anucleate)
What do T lymphocytes ( T cells ) do
function for immune response by acting directly against virus infected cells or tumor cells
What are the steps of Hemostasis in order
1) Vascular Spasm, 2) Platelet plug, 3) coagulation
Describe Vascular spasm
Damaged blood vessels vasoconstrict ( smooth muscle contract)
Chemical release by endothelial cells and activated platelets
Bigger damage more effecient
What are characteristics of monocytes
Largest ( 12-20 microns)
What are monocytes “job”
Turns into macrophages to fight virus, certain bacteria, and chronic infections
What type of macrophages does monocytes turn into
alveolar macrophages in lungs
Kupffer Cells in liver
What cells do platelets derive from
megakarytocytes
What are platelets used for
Clotting process in the blood vessels
What hormone regulates the formation of platelets
thrombopoietin
What are the events of Hemostasis
Vascular Spasm, Platelet plug, coagulation
What are the steps of vascular spasm
Damaged blood vessel stimulates pain receptors
Reflex contraction constrict smooth muscle of small blood vessels
Vascular spasm only occurs with what type of blood vessels
Small blood vessels and ateriole
What triggers vascular spasm
damaged vascular smooth muscle
chemical released by damaged endothelial cells
activated platelets
What is the steps of platelet plug formation
When endothelium cells is damaged and collagen fibers are exposed, platelets adhere via willebrand factor
What prevents platelets from adhering when there is no damage
Endothelial cells release nitric oxide and prostacyclin
What does it mean for platelets to become activiated
The swell
for spike processed
becomes stickier
What chemicals platelets release
ADP, Serotonin, thromboxane A
What are platelet-derived growth factor
causes proliferation of vascular endothelial cells, smooth muscles and fibroblast to repair damaged vessels
In platelet plug formation, what are alpha granules
Clotting fibers
platelet-derived growth factors
In platelet plug formation, what are dense granules
ADP, serotonin, and thromboxane A
How long can vascular spasm can prevent blood loss
20-30 mins
What do ADP, Serotonin, thromboxane A do
They are vasoconstrictors
Describe Coagulation/Blood clotting
Blood becomes liquid to gel via fibrin thread
What substances are needed for clotting
Ca+2
enzymes synthesized by liver cells
Substances release by platelets or damaged tissues
What is Clotting Cascade
Prothrombinase & Ca+2 convert prothrombin into thrombin
thrombin coverts fibrinogen into fibrin threads
Describe the Extrinsic pathway
Damaged tissue leak thromboplastin into bloodstream
Prothrombinase
In the presence of Ca+2 clotting factor X combines with V to form prothrombinase
Describe the Intrinsic pathway
Endothelium is damaged & platelets come in contact with collagen of blood vessel wall
Platelets damaged & release phospholipids
Requires several minute for reaction to occur
Substances involved Ca+2 and clotting factors XII, X , V
Describe the common pathway
Prothrombinase and Ca+2 catalyze the conversion of prothrombin to thrombin
In the presence of Ca+2 converts soluble fibrinogen to insoluble fibrin threads
Activates fibrin stabilizing factor XIII