Anatomy and physiology of pain Flashcards

1
Q

Define pain

A

an unpleasant sensory and emotional experience associated with or resembling actual or potential tissue damage

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2
Q

why is pain important

A

it is necessary as it acts as a warning system

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3
Q

what is a noxious stimulus

A

a stimulus that is actually or potentially damaging to the tissue - can be thermal, mechanical or chemical

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4
Q

define pain perception threshold

A

the minimum intensity of noxious stimulation that must be reached prior to pain being felt

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5
Q

define pain tolerance level

A

the maximum amount of pain an individual can tolerate

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6
Q

define analgesia

A

less or absence of pain in response to a typically painful stimulus

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7
Q

define hyperalgesia

A

increased sensitivity and response to a painful stimulus

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8
Q

define hypoalgesia

A

decreased sensitivity to a painful stimulus

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9
Q

define allodynia

A

pain resulting from a stimulus that would not normally provoke pain

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10
Q

how is pain detected

A

nociception and nociceptors

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11
Q

define nociception

A

the process by which information is conveyed to the CNS as a result of the stimulation of specialised sensory receptors in the peripheral nervous system

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12
Q

what are nociceptors

A

free nerve endings located throughout the body which are sensitive to tissue trauma and detect potentially damaging noxious stimuli, ultimately leading to the sensation of pain

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13
Q

describe nociceptive pain

A

normal warning response to tissue damage
pain corresponds to severity of the tissue trauma
fast, rapid onset, sudden sharp pricking pain,, followed later by a dull, aching or burning pain
pain will resolve but can be recurrent

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14
Q

what are the 3 types of stimuli which nociceptors respond to

A

thermal, mechanical, chemical

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15
Q

what are the 3 types of nociceptors

A

type 1 alpha delta fibres
type 2 alpha delta fibres
C-fibres

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16
Q

describe type 1 alpha delta fibres

A

fast transmitting, small diameter, myelinated nerve fibres
respond to mechanical stimuli
rapid, sharp, localised pain

17
Q

describe type 2 alpha delta fibres

A

fast transmitting, small diameter, myelinated nerve fibres
respond to thermal stimuli
rapid, sharp, localised pain
dorsal horn

18
Q

describe C-fibres

A

slower, smaller, unmyelinated nerve fibres
polymodal - respond to a variety of tissue-damaging inputs (mechanical, chemical and thermal stimuli)
slow, dull, aching pain

19
Q

what are the 4 phases of nociception

A

transduction
transmission
perception
modulation

20
Q

describe the pain gate theory

A

there is a ‘gate’ in the brain, through which painful stimuli are allowed to pass or get blocked
the gate can either be open or closed
if open, painful signals can pass through, and be perceived by the brain to cause pain
if closed, signals will be blocked and sensation of pain will not be felt

21
Q

what is peripheral sensitisation

A

normal protective process
lower threshold for activation
hypersensitivity to non- painful stimuli
if prolonged, can lead to abnormal pain state

22
Q

what is central sensitisation

A

basis for chronic pain
increased sensitivity of CNS to noxious stimuli
hyperalgesia - increased pain response to normally painful stimuli
pain outlives pathology - pain percieves more tissue damage than there is

23
Q

what is exercise induced hypoalgesia (EIH)

A

a decrease in sensitivity to painful stimuli with exercise