Anat 0502FA

Question 1

chloride-bicarb antiport

Answer 1

on RBC membrane.
physiologic chloride shift.
allows RBC to transport CO2 from periphery to lungs for elimination.

Question 2

anisocytosis

Answer 2

varying RBC sizes

Question 3

poikilocytosis

Answer 3

varying RBC shapes

Question 4

plt dense granules

Answer 4

contain ADP, calcium

Question 5

plt alpha granules

Answer 5

contain vWF, fibrinogen

Question 6

where is one-third of plt pool stored?

Answer 6

spleen

Question 7

what prevents RBC leakage from damaged vessels?

Answer 7

plts

Question 8

what results in petechiae?

Answer 8

thrombocytopenia or plt dysfunction

Question 9

vWf receptor

Answer 9

GpIb

Question 10

fibrinogen receptor

Answer 10

GpIIb/IIIa

Question 11

hypersegmented neutrophils

Answer 11

vit B12 and folate deficiency

Question 12

multilobed nucleus

Answer 12

neutrophils

Question 13

neutrophil granule contents

Answer 13

hydrolytic enz
lysozyme
myeloperoxidase
lactoferrin

Question 14

myeloperoxidase deficiency

Answer 14

can make bleach (hypochlorite) to kill phagocytosed organisms

Question 15

monocytes

Answer 15

in blood

macrophage = in tissue

Question 16

what activates macrophages?

Answer 16

gamma interferon

Question 17

cell surf marker for macrophages

Answer 17

CD14

Question 18

bilobed nucleus

Answer 18

eosinophils

Question 19

major basic protein

Answer 19

part of eosinophil defense vs. helminthic infx

Question 20

what are eosinophils highly phagocytic for?

Answer 20

Ab-Ag complexes

Question 21

eosinophil products

Answer 21

histaminase, arylsulfatase - limit rxn that follow mast cell degranulation

Question 22

causes of eosinophilia

Answer 22

"NAACP" 
Neoplastic
Asthma
Allergic process
Collagen vasc dz
Parasites (invasive)

Question 23

basophil granule contents

Answer 23

heparin - anticoag
histamine - vasodilation
other vasoactive amines
leukotrienes (LTD4)

*mediates allergic rxn

Question 24

where are Basophils found?

Answer 24

in Blood

mast cells found in tissue

Question 25

other than basophils, what cell mediates allergic rxn?

Answer 25

mast cells

Question 26

mast cell granule contents

Answer 26

histamine
heparin
eosinophil
chemotactic factors

Question 27

what do mast cells bind?

Answer 27

Fc portion of IgE to mast cell memb

Question 28

what hypersens rxn involves mast cells?

Answer 28

type I

Question 29

what prevents mast cell degranulation?

Answer 29

cromolyn sodium

*used as asthma prophylaxis

Question 30

what are the main inducers of primary Ab response?

Answer 30

dendritic cells (professional APCs)

Question 31

what happens when B cell encounters Ag?

Answer 31

B cell differentiates into plasma cells and produce Abs

Question 32

B cell markers

Answer 32

CD19, 20

Question 33

Th cell markers

Answer 33

CD3, 4

Question 34

cytotoxic T cell markers

Answer 34

CD3, 8

Question 35

what is the costimulatory signal needed for T cell activation?

Answer 35

CD28

Question 36

what cell comprises the majority of circulating lymphocytes?

Answer 36

T cells

Question 37

erythroblastosis fetalis

Answer 37

hemolytic dz of newborn (Rh+ baby) due to anti-Rh IgG that Rh- mom formed when exposed to Rh+ bld in PREVIOUS preg. anti-Rh IgG can cross placenta.

Question 38

prevention of erythroblastosis fetalis

Answer 38

Rho(D) immune globulin (rhogam) for mom at first delivery

Question 39

erythroblastosis fetalis presentation

Answer 39

severe anemia
hepatosplenomegaly
jaundice
possible fetal or infant death

Question 40

what class of Ig are anti-AB Ags (bld group)?

Answer 40

IgM - do NOT cross placenta