Anaphylaxis Flashcards
what is anaphylaxis
hypersensitivity reaction type 1
how many types of hypersensitivity reactions is there
4 types
type 1
IgE AB mediated- targeting allergen
Type 2
IgM and IgG AB mediated- targeting “self” Ag
Type 3
Immune complex mediated
Type 4
CD4+ and CD8+ mediated
Type 1 hypersensitivity reaction - Allergic reaction steps
- first exposure to environmental allergen (an other harmless antigen)- inhaled, ingested, injected, direct contact
- predisposed individual- Naive B- lymphocyte induced to produce IgE AB
- sensitization- IgE AB bind to surface of Mast cells and Basophils
- Re-exposure to the allergen
- Reaction- degranulation of mast cells and basophils with release of performed chemical mediators- Histamine, leukotrienes, prostaglandins and others, resulting in a number of effects
spectrum of type 1
Mild- Severe
Local- systemic
what is anaphylaxis
it is an acute, severe, life- threatening allergic reaction that is generalized/ systemic (multi organ), that occurs within seconds to minutes to hours to exposure to a known, or unknown, allergen. it may also be biphasic
anaphylaxis involves multiple systems
organs which anaphylaxis usually occur at
- skin and or mucosa (80%)
- respiratory system
- cardiovascular system
- gastrointestinal system
skin and or mucosa: superficial symptoms
flushing
urticaria (pruritic skin rash)
conjunctival injection
rhinorrhea
skin and or mucosa: deep symptoms
angiodema (painless swelling under the skin, commonly of the tongue, lips and peri-orbital region)
respiratory system: upper airway obstruction (pharynx ,larynx)
visual swelling. difficulty in swallowing, stridor, respiratory distress (increased respiratory rate and increased effort)
respiratory system: bronchospasm and increased mucous production
wheezes, respiratory distress (increased respiratory rate and increased effort)
cardiovascular system
vasodilation
increased vascular permeability
shock
cardiovascular system: vasodilation
leading to a form of distributive shock
cardiovascular system: increased vascular permeability
leading to intravascular depletion and potentially hypovolemic shock
define shock
hypoperfusion, reduced organ perfusion
types of shock
cardiogenic
obstructive
hypovolemic
distributive
what is sepsis
Sepsis is a serious and potentially life-threatening medical condition that occurs when the body’s response to an infection leads to systemic inflammation, widespread tissue damage, and organ dysfunction
shock on the CNS
dizziness, syncope, feeling of impending doom, headache, metallic taste
shock on the Cardiac
compensatory tachycardia, acute cardiac failure (acute drop in cardiac output, acute pulmonary edema, acutely raised JVP), ischemic chest pain dysrhythmias
shock on the respiratory system
compensatory respiratory distress
shock on the peripherals
measured low BP, weak peripheral pulses, warm pink peripherals (in the case of distributive shock)
shock on the gastrointestinal
diarrhoea and cramping (through increased smooth muscle contraction)
common allergens
food
venoms: bites , stings
medication: esp. muscle relaxants, NSAIDs incl. aspirin, antibiotics (penicillin), antivenom, IV contrast media (used in CT scans)