ANAPHYLAB M2 Flashcards
- A process in which a cell splits into two new cells to reproduce:
CELL DIVISION
cells of the body other than
reproductive cells
SOMATIC CELLS
reproductive cells
GAMETES/GERM CELLS
- the process in which cells grow and divide
CELL CYCLE
The cell is preparing
INTERPHASE
The cell is metabolically active, grows physically and replicates organelles and others
G1 PHASE
DNA is replicated to produce 2 sister chromatids and replicates its nucleosomes
S PHASE
Involves further cell growth, protein synthesis and centrosomes are completed
G2 PHASE
- phase where the cell is inactive (e.g. nerve cells)
G0
- Nucleolus disintegrate
- Chromatin condenses into chromosomes
- Formation of mitotic spindles made up of microtubules
PROPHASE
connects the pair of chromatids
which makes up the chromosomes
CENTROMERE
connects to the centromere and
links the chromosomes to microtubules
KINETOCHORE
Alignment of the chromosomes in the middle (equatorial plate)
METAPHASE
Centromeres are split and move to the opposite sides
ANAPHASE
- Nuclear envelopes form
- Chromosomes uncoil into chromatins
- Formation of 2 nuclei
TELOPHASE
- Cytoplasm division
- Occurs either at late anaphase or at telophase
- In Animals: formation of cleavage furrow through contractile ring
- In Plants: formation of cell plate
CYTOKINESIS
Uncontrollable cell growth; formation of abnormal cells
CANCER
- aka Neoplasm
- Excessive tissue formed
TUMOR
- study that deals with cancerous
cells/tumors
ONCOLOGY
tumors that undergo metastasis
MALIGNANT
- tumors that do not undergo metastasis (e.g. skin tags)
BENIGN
spreading to other parts of the body
METASTASIS
tumors form new blood vessels
ANGIOGENESIS
- malignant tumors that come from
epithelial cells
CARCINOMAS
skin cancer
melanoma
- muscle or connective tissues cancer
sarcoma
bones cancer
OSTEOGENIC SARCOMA
bone marrow cancer
LEUKEMIA
lymphatic tissue
lymphoma
- Plasma membrane that covers the entire cell
- Made up of: Phospholipid bilayer, Proteins (55%) and cholesterol
CELL MEMBRANE
- Difference in the concentration of a chemical from one place to another (inside to outside)
CONCENTRATION GRADIENT
- Difference in the electrical charges between two regions
ELECTRICAL GRADIENT
term for the charge difference
MEMBRANE POTENTIAL
Combined influence of the concentration gradient and electrical gradient on the movement of an ion
ELECTROCHEMICAL GRADIENT
Substances move down or with their concentration or electrical gradient without the use of ATP
PASSIVE TRANSPORT
random mixing of particles in a solution due to their kinetic energy
- Higher to lower solute concentration
DIFFUSION
- substances move freely without
the help of transport proteins
SIMPLE DIFFUSION
- an integral membrane protein (channel or carrier) assists a specific substance
FACILITATED DIFFUSION
through membrane channels (mostly ion channels) that allow passage of small, inorganic ions
CHANNEL-MEDIATED FACILITATED DIFFUSION
continuously allow the passage of ions
LEAK CHANNELS
- limits the movement of ions by opening/closing the pore by changing shape
GATED CHANNELS
● A carrier/transporter that changes shape
● Similarities with the Active Transport: transport maximum and saturation
CARRIER-MEDIATED FACILITATED DIFFUSION
Diffusion of water from an area of higher to lower water concentration; or from an area of lower to higher solute concentration
- Only takes place when a membrane is permeable
to water but impermeable to specific solutes
OSMOSIS
integral membrane proteins act as
water channels
AQUAPORINS
A solution that can change the volume by changing its water content
TONICITY
- Solution with higher solute concentration and water moves out from the cells
- Causes cell shrinking or crenation
HYPERTONIC
- Solution with lower solute concentration and water moves into the cell
- Causes cell bursting/rupture/lysis
HYPOTONIC
- Same concentration on both sides of the membrane
ISOTONIC
- Requires cellular energy in the form of ATP
- ATP is used to move substances against its gradient
ACTIVE PROCESS
- Hydrolysis of ATP changes the shape of a carrier protein which pumps a substance across the membrane against its concentration gradient
- Uses ATP ase
PRIMARY ACTIVE TRANSPORT
- The energy stored in an ionic concentration gradient is used (e.g. Sodium)
- Indirectly uses energy obtained from the hydrolysis of ATP
SECONDARY ACTIVE TRANSPORT
move two substances in the same
direction
SYMPORTERS
opposite directions
ANTIPORTERS
materials move into the cell in a
vesicle formed from the plasma membrane
ENDOCYTOSIS
highly selective; imparts materials that are needed by cells
RECEPTOR-MEDIATED ENDOCYTOSIS
- aka cell eating
- Phagocytes (s.g. WBCs) engulfs bacteria or viruses
PHAGOCYTOSIS
- pinocytosis, aka cell drinking
- Extracellular fluid is taken up
BULK-PHASE ENDOCYTOSIS
- material moves out of the cell by
fusion from the plasma membrane
EXOCYTOSIS
RBCs are destroyed in ________
hypertonic or hypotonic solutions
Hypertonic = ? (too much sodium)
● Hypotonic = ? (too little
sodium)
cerebral edema; dehydrated individuals
- a drug given to patients with heart failure; slows the action of sodium-potassium pumps
DIGITALIS OR DIGOXIN
- Genetic disorder that affects the active transport of chloride ions into cells
- Causes less water to move into the tubes
- Causes the tubes to become clogged with mucus
CYSTIC FIBROSIS
HIV and the CD4+ (T helper cell)
VIRUSES AND RECEPTOR-MEDIATED
ENDOCYTOSIS
Lung disease the damages the walls of air sacs (alveoli) of the lungs
EMPHYSEMA
have large surface area for the diffusion of O2 from air into blood
ALVEOLI