Analgesia Opioids Flashcards
What opioids are licensed for use in dos?
Fentanyl, methadone, pethidine, buprenorphine
What opioids are unlicensed?
Morphine
alfentanil
For Morphine list the duration of action, use and routes of administration
3-4hours
pre-medication and post-op analgesia
IV(bolus and CRI), IM, SC, epidural
For methadone list the duration of action, use and routes of administration
3-4hours
Premedication and post-op analgesia
iv(CRI bolus), IM, SC epidural
For pethidine list the duration of action, use and routes of administration
60 minutes
Pre-medication and post-op analgesia
IM, SC
For fentanyl list the duration of action, use and routes of administration
20-30minutes
intra-op and post-op
iv(bolus, CRI), transdermal
For buprenorphine list the duration of action, use and routes of administration
6 hours
premed and post-op
IV(Bolus), IM, epidural, Oral, transdermal
For butorphanol list the duration of action, use and routes of administration
60 minutes premed and post op analgesia and sedation IV (bolus), IM, SC kappa agonist mu antagonist
What are the characteristics of an opioid?
Safe to give to effect
Very safe group of drugs
What are the clinical effects of opioids?
Sedation
Analgesia
Cough suppression
What are the undesirable effects of opioids?
Respiratory depression -when opioids administered during anaesthesia makes respiratory centre less responsive to a rise in CO2 Cardiovascular effects -reduction in hear rate -dose and drug dependent Excitation -rare when given im -don't worry about excitation in cats Euphoria (inappropriately high doses Gut stasis Nausea and vomiting-Morphine before they are in pain Ocular effects (pupillary constriction
How is a drop in heart rate cause be administration of an opioid managed?
Administration of anticholinergenic
atropine
What factors should you consider before administering atropine?
low doses iv might promote bradycardia
high doses iv can stimulate tachycardia
Try to give im
if bradycardia develops on injection IV give more atropine
If tachycardia develops on iv injection wait
List the opioids in order from the most analgesic efficacy to the least
Fentanyl
methadone
buprenorphine
butorphanol
List the characteristics of methadone
More efficacious than morphine
reduced nausea and vomiting than morphine
no concern over histamine release if given IV
Minimal CVS and respiratory side effects
licensed in cats and dogs