Anagen effluvium

Question 1

Etiology.

rapid or slow onset?

Answer 1

Radiation therapy to head; chemotherapy with alkylating agents; intoxications; protein malnutrition

Anagen cycle disrupted causing varying degreeso hair ollicledystrophy:
■ Radiation therapy to head.
■ Alkylating agents: See Table 31-2.
■ Intoxications: Mercury, boric acid, and thallium.
■ Severe protein malnutrition.

rapid onset.

Question 2

Pathogenesis

Answer 2

Occurs after any insult to the hair follicle that impairs its
mitotic/metabolicactivity.
■ More common and severe with combination chemotherapy than with the use o a single drug.
Severity is generally dose dependent.

Question 3

manif hair and nails

Answer 3

Hair loss might be diffuse and extensive.

NAILS Showtransversebandingorridging

Question 4

When does hair growth recurr?

Answer 4

COURSE
■ Hair regrows after discontinuation of chemotherapy.

■ Regrowth after radiation depends on type, depth, dose ractionation; may result in irreversible hair ollicle stem cell damage.

Question 5

tx

Answer 5

none