Anaesthetics - Pain Flashcards
What are the benefits of treating pain?
Physical - improved sleep, appetite, fewer complications
Psychological - Reduced depression, anxiety
Family - functioning
Society - Lower health costs
What are the classifications of pain?
Duration - acute/chronic
Cause - cancer/non-cancer
Mechanism - nociceptive/neuropathic
What is nociceptive pain?
Obvious injury/illness
Physiological or inflammatory
Protective function
Sharp, well localised
What is neuropathic pain?
NS damage/abnormality Not obvious tissue injury Not protective Burning/shooting + numbness Not well localised
What are the steps in pain physiology?
Periphery
Spinal cord
Brain
Modulation
What is the function of the periphery in pain?
Tissue injury
Release of chemicals (prostaglandins, substance P)
Stimulates pain receptors
Adelta and C fibres to spinal cord
What is the function of the spinal cord in pain?
Second nerve travels up opposite side of cord
Dorsal horn is first relay station
What is the function of the brain in pain?
Thalamus is second relay station
Pain perception in cortex
What is the function of modulation in pain?
“Gate theory”
Descending pathway
from brain -> dorsal horn
Usually decreases the signal
What are the mechanisms for neuropathic pain?
Increased receptors
Abnormal nerve sensitisation
Chemical changes in dorsal horn
Loss of normal inhibitory modulation
What are the simple analgesics?
Paracetamol
NSAIDs
What are the opioids?
Mild - Codeine
Strong - Morphine, Fentanyl
Name some other drugs for analgesia not simple/opioid?
Tramadol Nefopam Antidepressants Anticonvulsants Ketamine
What pain treatments affect pain in the peripheral step?
RICE
NSAIDs
Local anaesthetics
What pain treatments affect pain in the spinal cord step?
TENS
Local anaesthetic
Opioids
Ketamine