Anaesthetics & Analgesics Flashcards
What are the 2 types of Anaesthetics?
General Anaesthesia
Local Anaesthesia
What is General Anesthesia ?
Unconsiousness
Loss of reflexes/Muscle relaxation
Analgesia
(short term amnesia)
What are the effects of General Anaesthesia?
Not all anaesthetics have equal activity in these characteristics
Anaesthetics may cause some motor inhibition, but neuromuscular blockers are often also added
General anaesthetics are known to interact with other proteins (receptors, ion channels)
What are the routes of administration of anaesthetics?
Inhalation anesthetics
Intravenous anaesthetics
What is the theory of aesthetic mechanisms?
Reduces neuronal activity which leads to unconsciousness.
What are the key concepts of anesthetic mechanism?
Increased inhibition
Reduced excitatory neurotransmission
Reduced excitability
potential other interactions
What are the other targets of general anaesthetics?
General anaesthetics are known to interact with other proteins (receptors, ion channels)
Varies by individual agent
enhancement of K+ channels (hyperpolarisation)
Inhibition of Na+ and Ca2+ channels?
Other receptors (nAChR, glycine, 5-HT3)?
What is the Mechanism Summary ?
There is not a single MoA for all general anesthetics
What is Isoflurane?
The most widely used inhalation anaesthetic
Medium Kinetics
What should be the cause of Isoflurane?
