Anaemia/iron/haemochromatosis Flashcards
When do you look for iron deficiency
Microcytic anaemia
Symptoms of
At risk of/prev IDA- heavy menstrual, veggie
Pre surgery - avoid transfusion
Standard pregnancy management - booking and 28 weeks
Iron deficiency symtpoms
Anaemia
Fatigue, poor conc, low mood
Hair thinning
Itch
Restless legs
Koilonychia, glossitis, pica
causes IDA
Diet - veggie
blood loss
malabsorption
Increased requirement for iron eg pregnancy
Blood loss causing IDA
Menstrual
GI bleed - ulcers, malignancy, inflammation, parasites
Blood donation
Who qualifies for an endoscopy/colonsocopy from IDA
All men and post menopausal women considered unless clearly non GI bleed
Investigation of IDA
Colonsocopy, endoscopy
Malabsorption - coeliac screen, helicobacter pylori
Urinalysis
Blood tests
What see on FBC in IDA
Hb - low or nomal
MCV<80 (some may be normal)
MCH <27
RBC - low/normal, RDW - normal/high
Blood film IDA
Hypochromia, microcytosis, pencil cells
Why does a normal or high ferritin not necessarily exclude IDA
High with inflammation and liver disease
What ferritin evels suggest IDA
<15 = no stores - pathogonomic
<30 - IDA
30-50 borderline/probable
<100 - = inflammation = possible IDA
Iron studies
Serum iron
Total binding iron capacity
Transferrin saturaiton
Not very useful IRL
Secondary tests for iron deficiency
Iron studies
Reticulocyte Hb <28
% hypochromic cells >6%
Zinc protoporphyrin >80
Oral trial of iron - improves by 20g/L in 3 weeks/Hb increases
Low MCV causes
IDA
Thalassemia/Hbinopathy
Anaemia of chronic disease
Lead poisonning
Inherited sideroblastic anaemia
Treating IDA
Diet
100-200mg elemental iron per day, 3 months after normal Hb
Aim for ferritin >50
What dietary iron is best absorbed
Haem iron from meat or fish
How is iron absorbed better
Prior to food - acid stomach
With vit C - fresh orange juice
Avoid antacids and tannins
What to do if oral iron not tolerated
Reduce dose to alternate days
Lower elemental iron/change formulation
Take w vit C, with food
Treat inflam conditions
Laxatives if constipated
Ensure compliance and no malabsorption, no haematinic deficiency
How does parenteral difffer to oral iron in terms of Hb
May initially work faster
4-6 weeks similar levels of Hb to oral iron
When is parenteral iron useful
Inflammation
Dialysis
Not tolerated oral despite trying
High levels of blood loss eg HereditaryHT elagniectasia
Complications pareneteral iron
Rare anyphylaxis, Low PO4, extravasation
What is hyperferritinaemia
Ferritin levels are high, doesnt necessarily mean iron is high
Causes of hyperferritinaemia
Inflammation incl AI disease, infection, malignancy
Liver disease, metabolic syndrome
Genetic haemohc=chromatosis
Renal failure
Myedodysplasia
THalassemia intermedia/major + other rare anaemias
Chronic blood transfusion
Porpphyria cutanea tarda
Other rare syndromes eg hereditary hyperferritenemia cataract syndrome, gauchers, acaeruloplasminaemia, friedrichs ataxia
What is high ferritin in men vs women
> 300 men
200 women
What do next when raised ferritin
Check FBC, U+Es, LFs, inflam markers, transferrin saturation
What does a high ferritin and abnormal FBC warrant investigatio for
Iron loaing apaemia
Haemolysis
Myedoplasia Thalassemia
When test for genetic haemochromatosis when high ferritin?
When trasnferrin saturations also high
eg >50% in men >40% in women
Check HFE genotyping
What can causes an isolated high ferritin
inflammation, malignancy, liver disease, metabolic syndrome etc
Genetic haemochromatosis why often not diagnosed
Often no clinically significnat iron overloading
Iron overlaoding symtpoms in haemochromatosis
Joint damage, osteoporosis
Endocrine - diabetes, gonadal sailure
Bronzed skin
Liver failure/cirrhosis HCC
Cardiac iron loading
Does high ferritin always cause iron overloading symptoms
No - only in people who have genetic haemochromatosis
Managment of haemochromatoss
Venesection 3-4 x a year aim for ferritin <50ug/L
Check for complications, family
Iron chelation if cant do venesection
Avoid vit C, reduce alcohol
Four initial tests for anaemia
Hb
MCV
Reticulocyte count
#Blood film/smear