Myeproliferative neoplasms

Question 1

Three types of MN

Answer 1

Polycythaemia
Myelofibrosis
Essential thrombocythaemia

Question 2

What presentation would indicate myelofibrosis

Answer 2

non-specific anaemia, massive splenomegaly, weight loss night sweats,

Question 3

What condition are tea drop poikilocytes ass with

Answer 3

Myelofibrosis

Question 4

What are howell joly bodies ass with

Answer 4

Hyposplenism
Or seen post splenectomy

Question 5

What are schistocytes seen in

Answer 5

Microangiopathic haemolytic disease

Question 6

What are spherocytes seen in

Answer 6

Hereditary spherocytosis, AI haemolytic anaemia

Question 7

Lab findings in myelofibrosis

Answer 7

anaemia
high WBC and platelet count early in the disease
‘tear-drop’ poikilocytes on blood film
unobtainable bone marrow biopsy - ‘dry tap’ therefore trephine biopsy needed
high urate and LDH (reflect increased cell turnover)
JAK V617 mutation

Question 8

Hashimotos disease

Answer 8

Hypothyroidism
Goitre
anti-TPO

Question 9

Recommended management of post MI conservative

Answer 9

Aspirin + either ticagrelor (not high bleeding risk)
Clopidogrel (high bleeding risk)