AML

Question 1

Myeloid lineage cells

Answer 1

Granulocyte, monocytes, erythroid, or megakaryotes

Question 2

WHO AML Classifications

Answer 2

AML with recurrent genetic abnormalities

AML with myelodysplasia-related features

Therapy-related AML and MDS

AML, not otherwise specified

Question 3

Complications of AML blasts

Answer 3

Anemia, bleeding increased risk of infection

Question 4

Incidence of AML in children.

Answer 4

Less than 10 percent of acute leukaemias in children less than 10

Question 5

How is AML diagnosed

Answer 5

By bone marrow biopsy using morphological, cytochemical, immunophenotypic, and cytogenics slash molecular analysis.

Question 6

In order to diagnose AML what percentage of the total cellularity in bone marrow must the blast forms account for

Answer 6

20% and must be identified as myeloid lineage

Question 7

What are erythematous to violaceous, tender nodules and plaques suggestive of acute neutrophil if dermatosis called

Answer 7

Sweet syndrome

Question 8

What are s/s of leukaemic involvement of the oropharynx?

Answer 8

Gingival hypertrophy, esp AML monocytic subtypes

Question 9

Name 4 electrolyte abnormalities in tumour lysis syndrome

Answer 9

Hyperphosphotemia, hypocalcemia, hyperuricemia, hyperkalemia