ALL

Question 1

NCI standard risk, lesser risk cytogenics, rapid response to therapy

Answer 1

Low risk

Question 2

Lesser risk cytogenics

Answer 2

Trisomy 4, 10

ETV-RUNX1

Hyper diploid

Question 3

Low risk survival

Answer 3

Greater than 95%

Question 4

NCI standard risk and rapid therapy response

Answer 4

Average risk (90-95% survival)

Question 5

NCI standard risk, lesser risk cytogenics, slow response to therapy

Answer 5

Average risk- intensified antimetabolite therapy (90-95 percent survival)

Question 6

NCI high risk group- rapid therapy response

Answer 6

High risk (88-90% survival)

Intensive multi agent chemo

Question 7

NCI standard risk and slow response to therapy

Answer 7

High risk (intensive multi agent 88-90%)

Question 8

CNS positive leukaemia

Or testicular leukaemia

Answer 8

High risk

Question 9

MRD + day 29

Answer 9

Very high - consider allogeneic HSCT in first remission

<80% survival

Question 10

Induction failure

Answer 10

Very high risk

Question 11

MLL rearrangements

Answer 11

Very high risk

Question 12

iAMP21 amplification

Answer 12

Very high risk

Question 13

Age <1 year or >13 years

Answer 13

Very high risk

Question 14

T cell ALL

Answer 14

Special groups ALL - intensive multi agent chemo 66-80% survival

Question 15

Philidelphia chromosome (t9;22)

Answer 15

Special groups intensive multi agent chemo containing a BCR ABL tyrosine kinase inhibitor

Question 16

NCI standard risk group

Answer 16

WBC < 50,000 microL and age 1-10

Question 17

MRD negative at day 8+29

Answer 17

Rapid response to therapy

Question 18

MRD positive day 8 neg day 29

Answer 18

Slow response to therapy

Question 19

NCI high risk group

Answer 19

WBC> 50,000, or age >10