Amiodarone Flashcards
1
Q
Amiodarone: Class
A
Antidysrhythmic
2
Q
Amiodarone: Mechanism of Action
A
- Prolongation of Action Potential
- Non-competitive alpha and beta sympathetic blocking effects
- Calcium channel blocking effects.
3
Q
Amiodarone: Indications
A
- Suppression of Ventricular Fibrillation refractory to defibrillation and Lidocaine.
- Suppression of Ventricular Tachycardia refractory to cardioversion and Lidocaine.
4
Q
Amiodarone: Contraindications
A
- Hypotension
- Bradycardia
- Profound Sinus Bradycardia.
- Second or Third Degree heart block.
- Medication-induced Ventricular dysrhythmias.
- Torsades de Pointes.
5
Q
Amiodarone: Adverse Reactions
A
Hypotension Bradycardia Pulseless Electrical Activity Congestive Heart Failure Nausea Fever Abnormal Liver Function Tests Thrombocytopenia
6
Q
Amiodarone: Drug Interactions
A
- Will precipitate with Sodium Bicarbonate: incompatible.
- Compatible with: Dopamine, Dobutamine, Isoproterenol, Lidocaine, NTG, Norepinephrine, Phenylephrine, KCL, Procainamide.
7
Q
Amiodarone: How Supplied
A
150 mg in 3 ml vials
8
Q
Amiodarone: Dosage and Administration
A
Adult:
- 300 mg slow IV Push over 1-2 minutes in 10 ml Normal Saline, (For ACLS VF/ Pulseless VT)
- 150 mg slow IV push over 1-2 minutes in 10 ml Normal Saline, (For Symptomatic VT with pulses)
- MAX DOSE 5mg/kg
- IV Drip 0.5-1mg per minute. (For malignant ventricular arrhythmias) per ordering physician.
9
Q
Amiodarone: Onset
A
Within 5-15 minutes
10
Q
Amiodarone: Peak Effect
A
Variable
11
Q
Amiodarone: Duration
A
Variable
12
Q
Amiodarone: Pregnancy Class
A
C
13
Q
Amiodarone: Special Considerations
A
- Maintain at room temperature and protect from light in storage (light protection not required during administration).
- Hypotension usually responsive to slowing infusion rate, IV Normal Saline.
- Administer cautiously in patients with Heart Failure or poor systolic function.
- May be especially effective in high-risk patients with recent acute MI.
