Aminosalicylates Flashcards
1
Q
What are examples of aminosalicylates?
A
- Mesalazine
- Sulfasalazine
2
Q
What is mesalaziine indicated for use in?
A
First-line - mild/moderate Ulcerative colitis
3
Q
What is sulfasalazine indicated for use in?
A
Rheumatoid arthritis
4
Q
What is the mechanism of action of aminosalicylates?
A
Release 5-aminosalicylic acids - have anti-inflammatory and immunosuppressive effects
5
Q
What are important side effects of aminosalicylates?
A
- GI upset
- Headache
- Leucopenia
- Thrmobocytopenia
- Renal impairment
- Oligospermia - sulfasalazine
- Serious hypersensitivity reaction
6
Q
When should aminosalicylates not be given?
A
When idividuals have hypersensitivity to aspirin
7
Q
What monitoring would you perform with aminosalicylate use?
A
- RA - CRP
- U+E’s, FBC, LFTs
