AM Comparative Modelling

Question 1

Eight steps

Answer 1

1. Identify templates
2. Align
3. Define SCR/SVR boundaries
4. Inherit SCRs
5. Build SVRs
6. Build sidechains
7. Refine the model
8. Evaluate errors in model

Question 2

SLoop

Answer 2

Blundell et al., 1997

Question 3

SCWRL

Answer 3

Dunbrack et al., 1997

Question 4

MODELLER

Answer 4

Sali and Blundell, 1993

Question 5

Insertions and deletions usually accommodated by small local changes in structurally variable regions, whilst the rest of the structure remains largely unperturbed

Answer 5

Greer, 1981