Alzheimer's Disease Flashcards
1
Q
Name four AChI used to treat AD.
A
Tacrine, Donepezil, Rivastigmine, Galantamine
2
Q
What is MOA for memantine?
A
partial antagonist of NMDA receptor
3
Q
Of the four AChI which can treat all stages of AD?
A
Donepezil
4
Q
What are the side effects of AChI excluding Tacrine?
A
N/V/sleep disturbance
5
Q
SE of Tacrine
A
N/V/D abdominal cramping
6
Q
Which of the AChI is not metabolized by P450 liver enzymes?
A
Rivastigmine
7
Q
What is memantine use to treat?
A
Severe AD
8
Q
SE of memantine?
A
Dizziness, confusion, headache, constipation
9
Q
How is memantine removed from body?
A
Excreted unchanged in urine
10
Q
Of the AChI, what has the longest half-life and only requires once daily dosing?
A
Donepezil
11
Q
Which AChI is available in a transdermal patch?
A
Rivastigmine
