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Pharm II Test 2 > Alzheimer's/Dementia > Flashcards

Alzheimer's/Dementia Flashcards

1
Q

Choline- Mech of Action

A

INCREASE ACH LEVELS

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2
Q

Choline- Clinical Use

A

Alzheimer’s

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3
Q

ACh Degradation inhibitors- Available Drugs

A

Tacrine
Donepezil
Rivastigmine
Galantamine

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4
Q

ACh Degradation Inhibitors- Mech of Action

A

INHIBIT ACETYLCHOLINESTERASE

= INCREASE ACH LEVELS

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5
Q

ACh Degradation Inhibitors- Clinical Use

A

Alzheimer’s

best response in patients with Lewy body variant of Alzheimer’s disease

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6
Q

Tacrine- Adverse Effects/Contraindications

A

Liver toxicity

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7
Q

Donepezil- Adverse Effects/Contraindications

A

Diarrhea, GI

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8
Q

Rivastigmine- Adverse Effects/Contraindications

A

Nausea, vomiting, GI

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9
Q

Cevimeline- Mech of Action

A

M1 (ACH) AGONIST

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10
Q

Cevimeline- Clinical Use

A

off label for Alzheimer’s

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11
Q

Nicotinic Agonists- Clinical Use

A

off label for Alzheimer’s

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12
Q

Memantine- Mech of Action

A

NMDA antagonist

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13
Q

Memantine- Clinical Use

A

Alzheimer’s

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14
Q

Pure Estrogens- Mech of Action

A

ALZHEIMER’S PROTECTIVE IF ADMINISTERED BEFORE ONSET OF SYMPTOMS

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15
Q

NSAIDs- Mech of Action

A

ALZHEIMER’S PROTECTIVE IF ADMINISTERED BEFORE ONSET OF SYMPTOMS

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16
Q

Statins- Mech of Action

A

ALZHEIMER’S PROTECTIVE

17
Q

Caffeine- Mech of Action

A

ALZHEIMER’S PROTECTIVE

18
Q

Beta Secretase- Mech of Action

A

UNDER INVESTIGATION FOR ALZHEIMER’S

19
Q

Neuroleptics: Haldol, Haloperidol- Mech of Action

A

TREAT SYMPTOMATIC AGITATION (Alzheimer’s and Huntingtons)

20
Q

Anti-Oxidants- Mech of Action

A

NO PROVEN BENEFIT IN ALZHEIMER’S

21
Q

Herbal Remedies- Mech of Action

A

NO PROVEN BENEFIT IN ALZHEIMER’S

22
Q

Clinical Use- Pure Estrogens, NSAIDs, Statins, Caffeine, Beta secretase, Neuroleptics (haldol, haloperidol), anti-oxidants, herbal remedies

A

Alzheimer’s

23
Q

Creatine- Mech of Action

A

EXPERIMENTAL FOR HUNTINGTON’S

24
Q

Clinical Use- Neuroleptics (haldol, haloperidol), Ciliary Neurotropic factor, glutamate antagonists, creatine, reserpine/tetrabenazine

A

Huntington’s

25
Q

Riluzole- Mech of Action

A

NA CHANNEL BLOCKER
= INHIBIT GLUTAMATE RELEASE

prolongs life slightly and somewhat improves quality of life

26
Q

Riluzole- Adverse Effects/Contraindications

A

liver toxicity

27
Q

Clinical Use- Neurotrophins, Human Recombinant insulin-like Growth Factor-I (hr-IGF-I)

A

ALS

28
Q

Riluzole- Clinical Use

A

ALS

Pharm II Test 2 (8 decks)

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