Alzheimer's/Dementia Flashcards
Choline- Mech of Action
INCREASE ACH LEVELS
Choline- Clinical Use
Alzheimer’s
ACh Degradation inhibitors- Available Drugs
Tacrine
Donepezil
Rivastigmine
Galantamine
ACh Degradation Inhibitors- Mech of Action
INHIBIT ACETYLCHOLINESTERASE
= INCREASE ACH LEVELS
ACh Degradation Inhibitors- Clinical Use
Alzheimer’s
best response in patients with Lewy body variant of Alzheimer’s disease
Tacrine- Adverse Effects/Contraindications
Liver toxicity
Donepezil- Adverse Effects/Contraindications
Diarrhea, GI
Rivastigmine- Adverse Effects/Contraindications
Nausea, vomiting, GI
Cevimeline- Mech of Action
M1 (ACH) AGONIST
Cevimeline- Clinical Use
off label for Alzheimer’s
Nicotinic Agonists- Clinical Use
off label for Alzheimer’s
Memantine- Mech of Action
NMDA antagonist
Memantine- Clinical Use
Alzheimer’s
Pure Estrogens- Mech of Action
ALZHEIMER’S PROTECTIVE IF ADMINISTERED BEFORE ONSET OF SYMPTOMS
NSAIDs- Mech of Action
ALZHEIMER’S PROTECTIVE IF ADMINISTERED BEFORE ONSET OF SYMPTOMS
Statins- Mech of Action
ALZHEIMER’S PROTECTIVE
Caffeine- Mech of Action
ALZHEIMER’S PROTECTIVE
Beta Secretase- Mech of Action
UNDER INVESTIGATION FOR ALZHEIMER’S
Neuroleptics: Haldol, Haloperidol- Mech of Action
TREAT SYMPTOMATIC AGITATION (Alzheimer’s and Huntingtons)
Anti-Oxidants- Mech of Action
NO PROVEN BENEFIT IN ALZHEIMER’S
Herbal Remedies- Mech of Action
NO PROVEN BENEFIT IN ALZHEIMER’S
Clinical Use- Pure Estrogens, NSAIDs, Statins, Caffeine, Beta secretase, Neuroleptics (haldol, haloperidol), anti-oxidants, herbal remedies
Alzheimer’s
Creatine- Mech of Action
EXPERIMENTAL FOR HUNTINGTON’S
Clinical Use- Neuroleptics (haldol, haloperidol), Ciliary Neurotropic factor, glutamate antagonists, creatine, reserpine/tetrabenazine
Huntington’s
