Altitude Flashcards
What does acute ascent to altitude result in?
Environmental hypoxia
What is the reduction in the amount of oxygen due to
Reduced barometric pressure at increasing altitudes
How does barometric pressure change partial pressure of inspired oxygen
The lower barometric pressure reduces the partial pressure of inspired oxygen
Hypobaric Hypoxia
The hypoxia associated with terrestrial altitude exposure
What is the percentage of oxygen in ambient air
Constant at 20.93% regardless of the altitude
T/F the percentage of oxygen in boulders is less than at sea level
False
What is the PiO2 in boulder (1630m)
122 mmHg
What is the PiO2 at sea level
149 mmHg
What three parameters need to be considered to to calculate PiO2
- Barometric pressure
- Water vapor pressure
- Percentage of oxygen in the environment
What is barometric pressure dependent on
Altitude
What is water vapor pressure (PH2O) in inspired air
47 mmHg independent on altitude
Sea level PiO2 calculation
(760 mmHg - 47 mmHg) * 0.2093= 149 mmHg
How does acute reduction in PiO2 affect oxygen levels in the blood?
Reduced PiO2 leads to a decrease in alveolar partial pressure of oxygen which leads to a reduction in the partial pressure of oxygen in arterial blood
What is the pressure of oxygen in arterial blood (PaO2) determinant of?
Major determinant of arterial hemoglobin O2 saturation (SaO2)
What happens at the top of the hemoglobin oxygen dissociation curve?
Small changes in PaO2 have minimal effect on SaO2