ALT- Alanine Transferase

Question 1

What is the normal value for ALT?

Answer 1

40 U/L

Question 2

What is the predidominate source of ALT? This makes it more specific or less ?

Answer 2

Liver, more specific

Question 3

When monitoring hepatoxic drugs what is the protocol for monitoring ?

Answer 3

If ALT is 1-3x NUL then monitor weekly F/U

If ALT is > 3x NUL then d/c or reduce dose

Question 4

If a pt has Jaundice and you are monitoring their liver enz what enz elevation would que your suspicion of a hepatic cause?

Answer 4

Elevated ALT

Question 5

If ALT is normal in a pt with Jaundice what could be a possible cause ?

Answer 5

Hemolytic anemia

Question 6

What are three other causes of elevated ALT ?

Answer 6

1. MI
2. Acute Trauma/ crush injury
3. Severe burns