ALP- Alkaline Phosphatase

Question 1

What is the source of Alkaline phosphatase as it pertains to the liver

Answer 1

Biliary Ducts

Question 2

What would cause marked elevation of ALP?

Answer 2

1. Biliary tract obstruction
2. infiltrative Dz
   - Tumors
   - abcesses

Question 3

What would be the expected result of ALP in peds?

Answer 3

Elevated due to growth

Question 4

What other key conditions would cause elevated ALP outside of the disease process?

Answer 4

Pregnancy -placenta
Oral contraceptives
Bone healing (processes)

Question 5

What is marked elevation in ALP ?

Answer 5

4x the NUL

Question 6

If ALP is predominately elevated in the presence of the other liver enzymes what autoimmune d/o should you consider in the DDx?

Answer 6

1. Primary Biliary Cholangitis (intra hep)

2. Primary Sclerosing Cholangitis ( intra or post hep)