Alpha-blockers

Question 1

Phenoxybenzamine

Answer 1

Non-selective, Irreversible

Uses: pheochromocytoma (used preop) to prevent catecholamine (hyptertensive) crisis

Question 2

Phentolamine

Answer 2

a1-selective, Irreversible

Uses: give to pts on MAOi who eat tyramine-containing foods

Question 3

Prazosin, terazosin, doxazosin, tamsulosin

Answer 3

a1-selective

Uses: Urinary symptoms of BPH; PTSD (prazosin); HTN (except tamsulosin)

SE: 1st dose orthostatic hypoTN, dizziness, HA

Question 4

Mirtazapine

Answer 4

a2-selective

Uses: depression

SE: sedation, increase serum cholesterol, increase appetite