Alpha and Beta Antagonists

Question 1

Alpha Adrenergic Antagonists are?

Answer 1

Phentolamine
Prazosin
Yohimbine
Phenoxybenzamine

Question 2

Phenoxybenzamine binds how?

Answer 2

Covalently to the alpha receptor causing an irreversible blockade

Question 3

Phentolamine, Prazosin,Yohimbine binds how?

Answer 3

Reversibly and is a competitive antagonist

Question 4

Phenoxybenzamine and Phentolamine, work on which sites

Answer 4

Presynaptic Alpha 2 and Post synaptic Alpha 1

Question 5

Prazosin works on which sites

Answer 5

Alpha 1

Question 6

Yohimbine works on which sites

Answer 6

Alpha 2

Question 7

Phentolamine effects Alpha 1 and 2 effects

Answer 7

A1 ->Peripheral vasodilation and decrease BP

A2->Increase in HR (Baroreceptor response) and CO

Question 8

Phentolamine onset and duration

Answer 8

Onset 2 min

Duration 10-15 minutes

Question 9

Phentolamine Alpha 1 and 2 effects

Answer 9

Alpha 1 -

Question 10

Phentolamine use

Answer 10

Acute HTN emergencies with intra-op manipulation of Phenochromocytoma

Question 11

Phentolamine Dose

Answer 11

30-70 mcg/kg continuous infusion

Question 12

Phenoxybenzamine is a ?

Answer 12

Haloalkylamine derivative

Nonselective Alpha Blocker

Question 13

Phenoxybenzamine onset

Answer 13

Slow 60 minute to peak effect

Question 14

Phenoxybenzamine side effects

Answer 14

Orthostatic Hypotension

Impaired vasoconstriction with Large BP drop with blood loss or vasodilating drugs (Volitiles)

Question 15

Phenoxybenzamine Clinical uses

Answer 15

BP control in Phenochromocytoma Pts

Excessive vasoconstriction in hemorrhagic shock

Question 16

Yohimbine is a

Answer 16

Alpha 2 antagonist causing increased Norepi release

Question 17

Yohimbine used to treat ?

Answer 17

Idiopathic Hypotension

Question 18

Prazosin is a?

Answer 18

Alpha 1 antagonist

Question 19

Prazosin dilates veins, arterioles or both

Answer 19

BOTH

Question 20

The Gold standard of Beta blockers is ?

Answer 20

Propranolol

Question 21

Chronic administration of Beta blockersis associated with ?

Answer 21

Up regulation of Beta receptors

Question 22

Which Beta Blockers are Selective Beta 1 antagonists in normal doses?

Answer 22

Metoprolol, Atenolol, Esmolol

Question 23

Bradycardia and myocardia depression are produce by Beta Blockers due to?

Answer 23

Blocking of the SNS to the heart

Question 24

Beta 1 blockade causes?

Answer 24

Decrease HR and CO

Question 25

Beta 2 blockade causes?

Answer 25

Increase Perif resistance including coronary resistance

Question 26

Chronic Propranolol use can cause what with fentanyl?

Answer 26

Decrease pulmonary first pass uptake

Question 27

Metoprolol A Beta 1 antagonist prevents

Answer 27

Increase in Inotropy and Chronotropy to Beta stimulation

Question 28

Esmolol

Answer 28

Beta 1 selective | Given IV only

Question 29

Esmolol Onset and Duration

Answer 29

Onset 5 min | Duration 10-30

Question 30

Esmolol elimination

Answer 30

Plasma esterases

Question 31

Esmolol Dose

Answer 31

0.2-0.5 mg/kg IV

Question 32

Beta Blocker can

Answer 32

Cross the BBB and Placenta | Alters airway resistance

Question 33

Beta Blocker contraindication

Answer 33

Existing AV block or Heart Failure. Not Recommended for COPD Pts May mask Hypoglycemia

Question 34

Cardiovascular effects of Beta Blockers reflect SNS innervation removal to the heart. AKA

Answer 34

Beta 1 Blockade

Question 35

NON selective Beta Blockers result in Beta 2 Blockade causing unopposed ?

Answer 35

Alpha 1receptor peripheral vasoconstriction

Question 36

Beta Blocker OD treatement

Answer 36

Atropine 7 mcg/kg Dobutamine if a pure BB Present Glucogon 1-10 mg IV (DRUG OF CHOICE)

Question 37

Beta 2 Blockers increase airway resistance T/F?

Answer 37

TRUE

Question 38

Clinical Uses Of Beta Blockers?

Answer 38

``` Treatment of HTN Angina Post MI Pre-op prep for Hyperthyroid Prevention of excessive SNS activity Suppression of cardiac dysrhythmias ```

Question 39

Labetalol is a ?

Answer 39

Alpha1 and Beta 1,2 Antagonist ( Blocker)

Question 40

Labetalol Dose

Answer 40

0.25 mg/kg

Question 41

Labetolol lowers BP by decreasing SVR Alpha 1 Blockade and prevents reflex tachycardia by ________?

Answer 41

Beta 1 blockade

Question 42

Labetalol does not change?

Answer 42

CO

Question 43

Labetalol side effects

Answer 43

Orthostatic Hypotension Bronchospasms CHF, Bradycardia, heart block