Allergy (0-5%) Flashcards
How do you confirm penicillin allergy?
Penicillin skin testing + oral challenge (if skin test positive, avoid penicillins).
How do you differentiate angioedema from triggers vs hereditary/ACEi angioedema?
Hereditary/ACEi angioedema not associated with pruritis or urticaria.
What are symptoms and lab findings of combined variable immunodeficiency? How do you treat?
Recurrent sinopulmonary infections
Low IgG, IgA or IgM AND poor response to vaccinations
Treat with IVIG or subcutaneous immunoglobulin
What are symptoms of urticaria?
Triggered by common antigens
Last typically < 48hrs (if >6 weeks without clear trigger, may be chronic spontaneous urticaria)
Heal without skin changes
Pruritis
If not consistent, need to look for autoimmune diagnoses
What is the diagnostic criteria for anaphylaxis?
Possible allergen +
Skin/mucosa + ONE of
Resp
HoTN
End organ dysfunction
Known allergen + HoTN
What is the IM and IV dose of epinephrine to treat anaphylaxis?
IM 0.01mg/kg (1:1000 dose, 1mg/ml) max 0.5mg
IV: 0.05-0.1mg IV bolus over 5 minutes then infusion (1:10000 dose, 0.1mg/mL)
What is Leser-Trelat sign?
Acute appearance of multiple seborrheic keratoses along with skin tags and acanthosis nigricans. Associated with GI and lung malignancy.