Allergy (0-5%) Flashcards

1
Q

How do you confirm penicillin allergy?

A

Penicillin skin testing + oral challenge (if skin test positive, avoid penicillins).

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2
Q

How do you differentiate angioedema from triggers vs hereditary/ACEi angioedema?

A

Hereditary/ACEi angioedema not associated with pruritis or urticaria.

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3
Q

What are symptoms and lab findings of combined variable immunodeficiency? How do you treat?

A

Recurrent sinopulmonary infections
Low IgG, IgA or IgM AND poor response to vaccinations

Treat with IVIG or subcutaneous immunoglobulin

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4
Q

What are symptoms of urticaria?

A

Triggered by common antigens
Last typically < 48hrs (if >6 weeks without clear trigger, may be chronic spontaneous urticaria)
Heal without skin changes
Pruritis

If not consistent, need to look for autoimmune diagnoses

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5
Q

What is the diagnostic criteria for anaphylaxis?

A

Possible allergen +
Skin/mucosa + ONE of
Resp
HoTN
End organ dysfunction

Known allergen + HoTN

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6
Q

What is the IM and IV dose of epinephrine to treat anaphylaxis?

A

IM 0.01mg/kg (1:1000 dose, 1mg/ml) max 0.5mg

IV: 0.05-0.1mg IV bolus over 5 minutes then infusion (1:10000 dose, 0.1mg/mL)

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7
Q

What is Leser-Trelat sign?

A

Acute appearance of multiple seborrheic keratoses along with skin tags and acanthosis nigricans. Associated with GI and lung malignancy.

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