All of cardio 2

Question 1

Role of LDL

Answer 1

goes to intimate where it is oxidised - OXLDL
OXLDL = atherogenic
Phagocytksed by macrophages –> foam cells –> fatty streak

Question 2

Why is HDL your ‘good cholesterol’

Answer 2

transport excess cholesterol from plasma to the liver where it is converted into bile and bile salts

Question 3

To which group do simvastatin and atorvastatin belong

Answer 3

statins

Question 4

Type of drug that inhibits HMG-Coa

Answer 4

statin

Question 5

When are statins ineffective

Answer 5

hypercholesterolaemia, because of the lack of LDL receptor

Question 6

S.E. of Statins

Answer 6

myositis

rhabdomylolosis

Question 7

First line drug in patients with a high triglyceride level

Answer 7

fibrates

Question 8

examples of fibrates

Answer 8

benzafibrate and gemfibrozil

Question 9

S.E. of fibrates

Answer 9

myostitis
GI symptoms
pruitis
itching

Question 10

contradictions of statin and fibrate use

Answer 10

pregnancy
never use together
avoid fibrates in alcoholics

Question 11

Drugs that inhabit cholesterol absorption

Answer 11

colestryamine
colestipol
colsevelam
and 
ezetimibe

Question 12

S.E. of ezetimibe

Answer 12

diarrhoea
abdo pain
headache
CONTRA in breast feeding