ALL

Question 1

What is the most common malignancy affecting children?

Answer 1

ALL

Question 2

What is the peak incidence?

Answer 2

2-5yrs

Question 3

State the features associated with the following:

• Anaemia
• Neutropenia
• Thrombocytopenia

Answer 3

• Anaemia: lethargy + pallor
• Neutropenia: frequent or severe infections
• Thrombocytopenia: easy bruising, petechiae

Question 4

State 4 other features that may be present in ALL

Answer 4

• Bone pain (secondary to bone marrow infiltration)
• Splenomegaly
• Hepatomegaly
• Fever
• Testicular swelling

Question 5

Name some poor prognostic factors for ALL

Answer 5

• Age <2y/o or >10y/o
• WBC > 20 @ diagnosis
• T or B cell surface markers
• Non-caucasian
• Male sex