Alimentary - Intestines Flashcards

1
Q

Inflammation of entire intestines

A

Enterocolitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Inflammation of cecum

A

Typhlitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Microvillus damage from zoonotic protozoa leading to malabsorptive/maldigestive diarrhea is associated with which pathogen?

A

Cryptosporidium

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Lamina propria invasion leading to capillary fibrin thrombi, mucosal necrosis, and effusive/exudative diarrhea is associated with which pathogen?

A

Salmonella

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Crypt cell necrosis leading to delayed repopulation of villus enterocytes and malabsorptive/maldigestive diarrhea is associated with which pathogen?

A

Canine/Feline Parvovirus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Microvillus damage from bacteria leading to malabsorptive/maldigestive diarrhea is associated with which pathogen?

A

Attaching & Effacing E. coli
(AEEC)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Dysmotility from intraluminal impaction causing diarrhea is associated with which pathogen?

A

Ascarids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Hypersecretion diarrhea from a structurally intact epithelium is associated with which pathogen?

A

Enterotoxigenic E. coli
(ETEC)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Diffuse granulomatous enteritis leading to effusive/exudative diarrhea is associated with which pathogen?

A

Mycobacterium avium paratuberculosis
(Johne’ Disease)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Villus enterocyte necrosis leading to replacement by immature enterocytes and malabsorptive/maldigestive diarrhea is associated with which pathogen?

A

Coronaviruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The most common neoplasm that causes segmental to multisegmental diffuse round cell infiltrates within the gastrointestinal tract of cats, horses, cows, pigs and dogs is:

A

Lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

All are considered PHYSICAL OBSTRUCTIONS of the gastrointestinal tract except [1] which is considered a FUNCTIONAL OBSTRUCTION.
1. GDV
2. Intussusception
3. Linear foreign body
4. Ileus
5. Large colon volvulus

A

Ileus
-can occur as post-op complication or due to peritonitis

ileus = stasis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Are there villi located in the large intestine (cecum/colon)?

A

NO

tight intercellular junctions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What are the 3 phases of intestinal injury?

A
  1. Acute
  2. Subacute
  3. Chronic
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the 4 intestinal reactions to acute injury?

A
  1. Mucoid (catarrhal) Exudate
  2. Hemorrhagic Exudate
  3. Diptheritic Membranes
  4. Villus Blunting (contraction)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the 4 intestinal reactions to subacute injury?

A
  1. Villus Fusion
  2. Crypt Abscesses
  3. Crypt Hyperplasia
  4. Epithelial Attenuation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What are the 4 intestinal reactions to chronic injury?

A
  1. Fibrosis
  2. Granulomatous Inflammation
  3. Lymphangiectasia
  4. Muscular Hypertrophy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Combination of Fibrin, Hemorrhage, & Cellular Debris common in virulent pathogen infections.

- commonly seen in Salmonella & Clostridium infections

A

Diptheritic Membranes

acute
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

The villi below are an example of:

acute
A

Villus Blunting

20
Q

The villi below are an example of:

e.g. coronavirus & parvovirus infections

subacute
A

Villus Fusion

also villus blunting

21
Q

The villi below are an example of:

e.g. Cryptosporidium, Lawsonia intracellularis infections

subacute
A

Crypt Hyperplasia

22
Q

The villi below are an example of:

subacute
A

Epithelial Attenuation

23
Q

The villi (or lack of) below are an example of:

- dysmotility, protein exudation/effusion, malabsorption/maldigestion

chronic
A

Fibrosis

a chronic reaction to injury

24
Q

The villi below are an example of:

chronic
A

Granulomatous Inflammation

25
The dilated lymphatic ducts (left) and lacteals within villi (right) combined show: | Cause **Protein Losing Enteropathy**
Lymphangiectasia
26
The intestinal wall below is an example of:
Muscular Hypertrophy
27
Inflammation of cecum and colon
Typhlocolitis
28
Inflammation of rectum
Proctitis
29
Inflammation of stomach and small intestine
Gastroenteritis
30
Inflammation of small intestine (just ileum)
Ileitis
31
Definition of diarrhea:
Secretion of **abnormally fluid feces** accompanied by * **increased volume** of feces * **increased frequency** of defecation
32
What are the 4 basic mechanisms of diarrhea?
1. Hypersecretion 2. Malabsorption/Maldigestion 3. Exudation/Effusion 4. Dysmotility
33
The normally functioning villi should possess:
* intact microvilli * tall columnar villus enterocytes * crypt epithelium (progressive differentiation up the villi)
34
Pathogen associated with hypersecretion diarrhea
**ETEC** * ENTEROTOXIN activates cAMP/cGMP -> FLUID SECRETION
35
# True/False Malabsorptive/Maldigestive diarrhea is a passive process via osmosis.
True
36
Intestinal causes of Malabsorptive/Maldigestive diarrhea
* microvillus damage/destruction * absorptive enterocyte necrosis/loss * crypt cell necrosis/loss * crypt hyperplasia -> epithelial attenuationl
37
Pathogens associated with **microvilli damage/destruction** in **Malabsorptive/Maldigestive diarrhea**
* **AEEC** * **Cryptosporidium**
38
Pathogens associated with **villus enterocyte necrosis** in **Malabsorptive/Maldigestive diarrhea**
* **Enteric Coronaviruses** - pigs (TGE), calves, cows, horses * **Enteric Rotavirus** * **Coccidia Protozoans**
39
Pathogens associated with **crypt cell necrosis** in **Malabsorptive/Maldigestive diarrhea**
**Radiomimetic Viruses** * **Canine & Feline Parvoviruses (FPLV)** - immunosuppression, diptheritic membranes, septicemia, SLOW regeneration, teratogenic effect (cerebellar hypoplasia) * **Bovine Viral Diarrhea Virus (BVDV)**
40
Key histological features of FPLV
* crypt necrosis * villus blunting & fusion * crypt regeneration
41
Pathogens associated with **crypt hyperplasia** in **Malabsorptive/Maldigestive diarrhea**
* **Lawsonia intracellularis** - proliferative enteritits, mucosal thickening
42
Pathogens associated with **villus enterocyte necrosis AND lamina propria damage** in **Exudative/Effusive diarrhea**
* **Salmonella** - zoonotic, virulence factors (flagella, fimbriae, LPS, endotoxin) * **Clostridium perfringens & C. difficile** - horses | Diptheritic membrane
43
Conditions associated with **lymphatic obstruction (PLE) / infiltrative disease** in **Exudative/Effusive diarrhea**
* **Mycobacterium avium paratuberculosis (Johne's Disease)** - granulomatous inflammation, protein losing-enteropathy (PLE) * **Lymphoma** - neoplastic infiltrates
44
What pathogen of cattle features gross lesions with thickened, **"corrugated" mucosa**, mucosal erosions, and **mesenteric lymphadenitis**. Histologically you will see **intracellular acid-fast bacilli**.
Mycobacterium avium paratuberculosis (Johne's Disease)
45
Dysmotility where there is **decreased contact time** with mucosa, leading to **maldigestion/malabsorption**
Hypermotility
46
Dysmotility where there is **bacterial overgrowth**, leading to toxic substance production/reduced fermentation, and secondary secretory or osmotic diarrhea.
Hypomotility