Align Module Flashcards

1
Q

what is the best evidence for when looking at interventions and screening, prevention, and therapy?

A

best is systematic reviews for RCTS

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2
Q

what are the parts of PICO

A

population
intervention
comparison
outcomes

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3
Q

what is equipoise

A

belief that the new treatment will be helpful and positive

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4
Q

what is placebo

A

sham treatment, sugar pill, etc

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5
Q

what is masking/blidning

A

making it so someone doesnt now that something is happening or what itnervention or placebo they are getting

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6
Q

what is bias?

A

all different types. that make it so that the study isnt fair

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7
Q

can blinding be bad?

A

yes if the treatment is dangerous, or if the resutls are really good. you would want to know

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8
Q

what is attrition bias?

A

a form of selection bias

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9
Q

how can you stop the attrition bias?

A

intent to treat analysis!

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10
Q

what is the highest level of evidence?

A

meta analysis

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11
Q

what is the lowest level of evidence

A

unsystematic clinical observations

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12
Q

what is the order of evidence in total

A

1) meta analysis
2) Systematic review of RCTS
3) single RCT
4) systematic review of controlled observational study
5) single controlled observational study (cohort is better than case control)
6) single uncontrlled observational study (case series better than case report) btu the rest in line with cross sectional and ecological
7) physiologic studies (blood pressure, etc)
8) unsystematic clinical observations (anecdotes, subjectives)

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13
Q

what is an ecologic observational study?

A

summaries, groups and aggregate measures

no causation is found

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14
Q

what is a case report and case series?

A

not controlled, new unusual occurances

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15
Q

what is cross sectional study? s

A

surveys, prevalance

sample at a point in time, data collected on exposures and outcomes

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16
Q

what is case control

A

begins with people with and without the condition. compared on an exposure they had in the past

17
Q

what is cohort?

A

follow up, longitudinal

groups followed over time to see if a symptom develops

18
Q

what is a hazard ratio?

A

similar to releative risk, risk ratio
often used interchangably with relative risk even though its calculated differently
calculated using survival analysis
relativ erisk calculates risk over a certain time span

hazard ratio calculates risk at a particularpoint in time
sinterpreted in a similar fassion

19
Q

what does a relative risk of 1 mean

A

no difference

20
Q

what does a relative risk >1 mean

A

higher (one is more harmful than the other)

21
Q

what is relative risk?

A

probability of an outcome in an exposed group to the probability of an outcome in an unexposed group

22
Q

what types of studies reveal clusters?

A

cross sectional