Alcohol Poisoning

Question 1

MOA of disulfiram

Answer 1

Inhibit enzyme aldehyde dehydrogenase.

Question 2

ADR of disulfiram

Answer 2

Concentration of acetaldeyde increases in tissues and blood and leads to a symptoms called aldehyde syndrome. It includes flushing burning sensation, throbbing headache, uneasiness, tightness in chest, dizziness, vomiting, visual disturbances, mental confusion, syncope and circulatory failure

Question 3

Disulfiram aversion therapy used for

Answer 3

Subjects who really desire to leave alcohol as it makes taking alcohol a bad experience

Question 4

Manifestations of methyl alcohol poisoning

Answer 4

Vomiting, headache, Epigastric pain, drunkenness, dyspnoea, bradycardia and hypotension
Acidosis
Retinal damage

Question 5

Management of methyl alcohol poisoning

Answer 5

1. Patient in a dark room
2. Gastric lavage with sodium bicarbonate
3. Combat acidosis with sodium bicarbonate
4. KCL infusion for Hypokalemia due to alkali therapy
5. Ethanol
6. Fomepizole
7. Hemodialysis
8. Folate therapy

Question 6

Ethanol administration dose for methyl alcohol poisoning

Answer 6

Nasogastric tube,
Loading doze 0.7ml/kg followed by 0.15ml/kg every hour

Question 7

Fomepizole MOA

Answer 7

Inhibit alcohol dehydrogenase
Marketed elsewhere as ANTIZOL