Alcohol in Nutrition Flashcards
What compound does ethanol structurally resemble?
Carbohydrates
What compound does ethanol metabolically resemble?
Fatty acids
Does ethanol have a high or low energy content?
High
Why are there no DRVs for alcohol?
Because it is not an essential nutrient
What percentage of energy do UK DRVs assume comes from alcohol?
5% = acts as an upper recommended limit
How many ml is one unit of alcohol?
10ml
What is the recommended average alcohol intake?
14 units a week
Where is alcohol readily absorbed?
Along the GI tract
Where is alcohol transported?
Unaltered in the blood
When is peak alcohol concentration of blood?
20-60 minutes after consumption
What are the two different ways in which alcohol can be metabolised?
Alcohol dehydrogenase pathway
Cytochrome P-450 system
Describe how alcohol is metabolised in the alcohol dehydrogenase pathway.
- Ethanol is converted to acetaldehyde by alcohol dehydrogenase
- Acetaldehyde is converted to acetic acid (= highly toxic) by aldehyde dehydrogenase
- Acetic acid is converted to acetyl CoA
- Acetyl CoA is used in the krebs cycle and for fatty acid synthesis
- NAD is converted to NADH at each stage (accumulation is toxic)
Why might increased alcohol consumption lead to damaged vision?
Alcohol dehydrogenase is used to convert retinol to retinal due to it being occupied in alcohol metabolism
Describe how ethanol is metabolised in the cytochrome-P450 system.
Ethanol is converted to acetaldehyde by cytochrome P-450
When is the cytochrome P-450 system induced?
As a result of chronic alcohol consumption