Alcohol and other Psychoactive Substance Use Flashcards
Drugs are classified according to how dangerous they are. Opioids are drugs that patients can become addicted to. Which class are opioids categorised in?
1 - class A
2 - class B
3 - class C
1 - class A
- includes codeine and heroin
Drugs are classified according to how dangerous they are. Opioids are drugs that patients can become addicted to. What is the primary action of opioids?
1 - act on GABA receptors
2 - act on opioid receptors
3 - increase noradrenaline/adrenaline
4 - serotonin and acetylcholine
2 - act on opioid receptors
- mainly used as analgesics
Drugs are classified according to how dangerous they are. Stimulants, such as cocaine and speed are drugs that patients can become addicted to. Which class are opioids categorised in?
1 - class A
2 - class B
3 - class C
1 - class A
Drugs are classified according to how dangerous they are. Stimulants, such as cocaine and speed are drugs that patients can become addicted to. What is the primary action of stimulants?
1 - act on GABA receptors
2 - act on opioid receptors
3 - increase noradrenaline/adrenaline and dopamine
4 - serotonin and acetylcholine
3 - increase noradrenaline/adrenaline and dopamine
Drugs are classified according to how dangerous they are. Sedatives, such as benzodiazepines, alcohol and pregabalin are drugs that patients can become addicted to. Which class are these sedatives categorised in?
1 - class A
2 - class B
3 - class C
3 - class C
Drugs are classified according to how dangerous they are. Sedatives, such as benzodiazepines, alcohol and pregabalin are drugs that patients can become addicted to. What is the primary action of sedatives?
1 - act on GABA A and B receptors
2 - act on opioid receptors
3 - increase noradrenaline/adrenaline and dopamine
4 - serotonin and acetylcholine
1 - act on GABA A and B receptors
Drugs are classified according to how dangerous they are. Hallucinogens, such as LSD/psilocybin and mushrooms are drugs that patients can become addicted to. Which class are these hallucinogens categorised in?
1 - class A
2 - class B
3 - class C
1 - class A
Drugs are classified according to how dangerous they are. Hallucinogens, such as LSD/psilocybin and mushrooms are drugs that patients can become addicted to. What is the primary action of hallucinogens?
1 - act on GABA A and B receptors
2 - act on opioid receptors
3 - increase noradrenaline/adrenaline and dopamine
4 - serotonin and acetylcholine
4 - serotonin and acetylcholine
Drugs are classified according to how dangerous they are. Cannabis is a drug that patients can become addicted to. Which class are these hallucinogens categorised in?
1 - class A
2 - class B
3 - class C
2 - class B
Drugs are classified according to how dangerous they are. Cannabis is a drug that patients can become addicted to. What is the primary action of cannabis?
1 - act on CB1 and CB2
2 - act on opioid receptors
3 - increase noradrenaline/adrenaline and dopamine
4 - serotonin and acetylcholine
1 - act on CB1 and CB2
Which group of patients is most at risk of using drugs?
1 - those earning >£100,000
2 - those earning >£50,000
3 - those earning <£50,000
4 - those earning <£10,000
4 - those earning <£10,000
Which of the following are dangerous effects of substance use?
1 - accidents
2 - overdose
3 - violence
4 - suicide
5 - breakdown of relationships
6 - unplanned pregnancy
7 - all of the above
7 - all of the above
Which of the following is NOT a common risk factor for substance use?
1 - stress
2 - gender
3 - poverty
4 - trauma
5 - mental illness
6 - genetics
2 - gender
- drugs are often described as self medicating
- typically this is a cumulative effect of multiple risk factors
- protective factors can mitigate risk factors
Which of the following is NOT a common risk factor that patients with mental health and substance users typically have?
1 - trauma/abuse
2 - age
3 - stress
4 - genetics
2 - age
In acute alcohol use what would we expect to see in GABA-A and NMDA receptors?
1 - GABA and NMDA agonist
2 - GABA and NMDA antagonist
3 - GABA agonist and NMDA antagonist
4 - GABA antagonist and NMDA agonist
3 - GABA agonist and NMDA antagonist
- NMDA is glutamate
- GABA A
Patients who associate alcohol with a positive valence (which increases dopamine release) and associate with a feeling of reward when consumed will have increased dopamine release from the ventral tegmental area (VTA). What effect does alcohol then have on the VTA?
1 - NMDA (glutamate, an excitatory neurotransmitter) antagonist of cortical input disinhibits VTA and increases dopamine
2 - GABA receptor antagonist of cortical input disinhibits VTA and decreases dopamine
3 - NMDA (glutamate) agonist of cortical input disinhibits VTA and decreases dopamine
1 - NMDA (glutamate, an excitatory neurotransmitter) antagonist of cortical input disinhibits VTA and increases dopamine
- causes an increase in dopamine release to the nucleus accumbens
- means we continue to want alcohol to get the same reward effects
- nucleus accumbens = main dopamine nucleus)
- located in the midbrain
Which of the following drugs is used to treat alcohol dependence?
1 - adenosine
2 - haloperidol
3 - disulfiram
4 - lithium
3 - disulfiram
Disulfiram is used to treat alcohol dependence. What is the mechanism of action of this drug?
1 - agonist of NMDA receptors and increases glutamate
2 - inhibits GABA A receptors
3 - inhibits aldehyde dehydrogenase
4 - all of the above
3 - inhibits aldehyde dehydrogenase
Disulfiram creates unpleasant side effects when alcohol is consumed, so acts as a deterrent
In chronic alcohol we can see dependency, which is where the patient cannot function normally without alcohol. What would we expect to see in GABA and NMDA receptors?
1 - GABA and NMDA receptors upregulated
2 - GABA and NMDA receptors downregulated
3 - GABA receptors downregulated and NMDA receptors upregulated
4 - GABA receptors upregulated and NMDA receptors downregulated
3 - GABA receptors downregulated and NMDA receptors upregulated
- down regulation of GABA-A receptors because alcohol acts as an agonist so less receptors are needed
- up-regulation of NMDA (glutamate) receptors as alcohol is an antagonist, so more receptors needed to increase sensitivity
- the increased number of NMDA receptors means the firing rate of the NMDA receptors returns to a normal level as a compensatory mechanism
What scoring tool is used to assess a patients alcohol withdrawal?
1 - CWAR score
2 - Wells score
3 - Chad-vasc score
4 - AUDIT-C
1 - CWAR score
Typically, how long is it before a patient begins to have withdrawal symptoms following cessation of alcohol?
1 - <6hours
2 - <12 hours
3 - <24 hours
4 - <48 hours
2 - <12 hours
- can be variable though
Which of the following medications is typically used in alcohol withdrawal?
1 - chlordiazepoxide
2 - haloperidol
3 - disulfiram
4 - lithium
1 - chlordiazepoxide
- essentially benzodiazepines
During withdrawal from alcohol, patients can experiencer tonic (muscle stiffening) /clonic (twitching or jerking) seizures that resemble epilepsy. Which of the following is also common?
1 - Tremor
2 - Sweating
3 - Anxiety
4 - Tachycardia
5 - Insomnia
6 - Nausea/vomiting
7 - All of the above
7 - All of the above
Delirium tremens can occur in a patient in alcohol withdrawal, typically after 3 days. Which of the following are features of delirium tremens?
1 - rapid onset of confusion
2 - severe tremor
3 - clouding of consciousness
4 - paranoia
5 - agitation
6 - autonomic instability
7 - all of the above
7 - all of the above
- high mortality rate if not treated
Delirium tremens can occur in a patient in alcohol withdrawal, typically after 3 days and carries a high mortality. Which 2 of the following is typically used to treat this?
1 - chlordiazepoxide
2 - haloperidol
3 - disulfiram
4 - thiamines
1 - chlordiazepoxide
4 - thiamines (B1)
Wernicke’s encephalopathy is a degenerative brain disorder caused by the lack of vitamin B1 (thiamine) and can occur in alcohol withdrawal. Which of the following is NOT part of the typical triad of Wernicke’s?
1 - Confusion
2 - Ataxia
3 - Ophthalmoplegia (paralysis/weakness of the eyes)
4 - Tremor
4 - Tremor
- important to treat Wernicke’s asap as this can lead to permanent neurological damage
- Nystagmus can also occur
What is the locus coeruleus, which in Latin means “blue spot”?
1 - nucleus in the pons of the brainstem responsible for dopamine synthesis
2 - nucleus in the pons of the brainstem responsible for the synthesis of norepinephrine
3 - nucleus in the pons of the brainstem responsible for the synthesis of corticol
4 - nucleus in the pons of the brainstem responsible for the synthesis of serotonin
2 - nucleus in the pons of the brainstem responsible for the synthesis of norepinephrine
- principal site for brain synthesis of norepinephrine
- involved in stress and panic (fight or flight response)