AINES Flashcards

1
Q

Leucotrienos

A

LOX

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2
Q

quien sintetiza leucotrienos

A

LOX

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3
Q

precursor de tromboxano y leucotrienos

A

ácido araquidónico

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4
Q

células que causan vasodilatación

A

prostaglandinas y prostaciclinas

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5
Q

función tromboxano 2

A

promover agregación plaquetaria y formar costra

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6
Q

pricipales mediadores inflamatorios y vasodilatadores de las COX

A

PGE2 y PGI2

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7
Q

COX-1

A

Siempre esta presente en el organismo

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8
Q

COX-2

A

esta presente solo cuando hay inflamación o lesión

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9
Q

AINE con buena actividad plaquetaria

A

Acido acetilsalicilico

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10
Q

paracetamol

A

acetomifen

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11
Q

fármaco de unión IRREVERSIBLE a COX-1

A

Aspirina

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12
Q

que pasa en una sobredosis por aspirina?

A

acidosis metabólica

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13
Q

Función de la aspirina

A
  • analgesico
  • antiplaquetario a dosis bajas
  • antipiretico
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14
Q

tx acidosis metabolica por sobredosis de aspirina

A

Bicarbonato y carbon activado

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15
Q

inhibidores reversibles de la COX

A
  • Ketorolaco
  • ibuprofeno
  • indometacina
  • diclofenaco
  • naproxeno
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16
Q

farmacos selectivos de COX-2

A
  • celecoxib
  • rofecoxib
17
Q

cuál es el mejor antipirético?

A

Acetaminofen

no es antiinflamatorio

18
Q

efectos adversos acetaminofen

A
  • hepatotoxico
  • CYP450: metabolitos toxicos
19
Q

farmacos reversibles de las cox no selectivos por vía parenteral

A
  • Ibuprofeno
  • ketorolaco
  • indometacina