Agents infectieux facteur de virulence Flashcards
VP4, VP7 = attachement
Rotavirus (RNA non E)
NSP4 (enterotixin)
Rotavirus RNA non E
Glycoprotein G binds LDL-R
targets squamous epithelium
Arbovirus (RNA E)
Glycoprot E1, E2 attache crypt
Lysis PP, necrosis vascular wall
BVD (pestivirus, RNA, E)
Target CD150 (lympho)
SLAM
Rinderpest (morbili RNA E)
FIL attache heparan-R
synthesis VEGF = angiogenesis
Parapox DNA E
Echtyma contagieux
VP1 à 4 attache
R-integrin VB1-3-6
Aphtovirus RNA non E
Foot and mouth dz
S prot binds sialic acid in mucus layer
E2 = entry
Coronavirus RNA E
GIT
VP14 attache
R=ICAM
Enterovirus RNA non E
swine vesicular dz
tropisme endothelial cell -> CIVD
Calicivirus RNA non E
exanthème Fe
Need duplex transcription template = only in S phase
R= transferrin (Ca)
R = transferrin, neuraminic acid (Fe)
Parvovirus DNA non E
Lysis epithelial/endothelial cells
Fiberprotein = attache
R-integrin (coxackievirus-adenovirus)
Phlebovirus DNA non E
Rift valley
HA = entry
NA = shedding
HA/NA bind to target sialligosaccharide
Orthomyxovirus RNA E
Influenza Eq
Glycoprot B, C, D = attache
Mediator A, nectin 1-2, 3-0 sulfate heparin = entry
Trigeminal/olfactive nerve (retrograde axonal)
Active by multiplication by axonal transport to mucosa and going into epithelial cells
Herpesvirus DNA E
IBR
What does latent virus mean?
Latent = NO CMH II. LOW CMH I = less CTL, macro
Virus in nucleus without protein synthesis
Glycoprotein G = attache
Glycoprotein F = fusion
TLR3-4 for inflamm
Pneumovirus RNA E
syncitial
Infects monocytes precursors in bone marrow = reservoir
Genome inserted on chromosomal DNA = persiste infection
Chronic inflamm lung, brain, mammary, synovial, demyelinating encephalitis
Lentivirus RNA E
Maedivisna
R = Sialoadhesin, CD163, heparan
Acute inflamm mucociliary -> bact infection
Arterivirus RNA E
SRRP
Infect injure erythroid precursors
= neonatal anemia
Herpesvirus (cytomegalovirus) DNA E
inclusion body rhinitis
PAS CONTAGIEUX
bite from midges
Capside VP2, VP5, NS3 (insertin)
Cytotoxin (viroporin)
Source = semen accessory glands
Orbivirus RNA non E
African horse sickness
Lysis vascular endothelium
Lysis lymphocytes
Vasculitis
Dead-end host because spread need free cell virus = don’t exist
Gammaherpesvirus DNA E
fièvre catarrhale maligne
Erns, E2 envelop, glycoprotein
Pestivirus RNA E
Classical swine fever
Envelop glycoprot = p12, p54, p30
Asfivirus DNA E
African swine fever
Glyco = B, C, D
basse temperature helps
Canine herpesV type I
Antigenic shift/drift of 3c genes in mucosal macrophages
S1, S2, M, E = attache
PIF
What is the immune response in PIF? SC?
HIGH cell mediated = no PIF
LOW cell mediated = dry
NO cell mediated = wet
effective HUMORAL = more severe
Adequate AC = hyperS III -> complement => neutro
Type 4 in some pygranulomas
envelop gp120, gp90
R-lentivirus-R-1
Cell free vitus act as hapten on RBC -> phagocyte + présente lympho -> humoral response -> hyperSe II
What happens if haptens active complement?
Lentivirus
Anemie infectieuse equine (bloodborne)
active complement = RBC lysis
Changement LB (gene transactivation)
Provirus infected LT
gp51, gp30 enter naive LB = express IgM
CD5, CD11b = susceptible infection
p34tax = prolif LB = X virus + growth/differenciation
Deltavirus
Leukemia Bo
Need S phase X
Macro non permissive
Lympho permissive
Circovirus 2
LB spread virus
LT = #1 target
Need fast dividing cells
Persistent LT infection = clinical signs
Surface Su, TM
Retrovirus
Leukemia Fe
infect CD4+
SU, TM
Target CD134, CXCR4
Lentivirus
FIV
Dysrupt neurotransmitter fct
Gprot -> NT-R -> Muscle -> X -> interstitial bind acetylcoA, ganglioside -> retrograde (dynein) -> nerfs 7 (facial), glossopharyngien (9)
Lyssavirus
rabies
dysfct endo cell of arterioles in brain + spinal cord
immune complex
alphaherpesvirus
encephalite equine
Target neurons cell bodies
+++ CTL, retrograde axonal
alphaherpes
Pseudorabies
viral H prot + fusion protein F
R = CD150 (SLAM)
Distemper
Morbilivirus
NS1 produced by virus = TOXIC
Feline parvovirus
cerebral hypoplasia
dysfct gene prolif/diff/adhesion
Integrin a6B4 - heparan sulfate = attache
Bovine L1, L2 capside
basal cell = non permissive = reservoir = X genome
virus mature on the way to upper layer = complete cycle
what does it mean if the cell doesn’t go into the target cell? if integrate in suprabaal layer)
Viral papilloma
warts, sarcoids
NO = benign (no permissive)
upper = malin (permissive)
Action of E5
active R-PDGF, EGF
inhibe CMH I
action E6
Inhibe p53, BAK
active telomerase, BCL2, mTOR, MYC
action E7
Active HIFa
baisse Rb, p21
favorise bris DNA
only between cats
persistent infection of MO (LT precursor) = baisse immun cell mediated = baisse CTL, baisse IFNy, IL secreted by LT, dysfct neutro/macro
R = feline thiamine transport protein
FeLVA
Shift recombination of type A
neoplastic change
R = feline phosphate transporter protein 1-2
FeLV B
Point mutation (antigenic drift)
anemia
R = FeLVCR
FeLVC
Infects LT = immunosuppressive syndrome
R = FePIT1
FeLVT
Secreted by LT = restrict tropism to LT
FeLVX
caracteristic of reovirus (FeLV)
produce reverse transcriptase (reo) to transcribe viral RNA into proviral DNA = insertion chromosome LT
Where is FOCMA expressed in FeLV
expressed on cell membrane of changed cells
NOT on infected or not transformed cell
Type 1 fimbriae, S, P
bind uroplakin-R
UPEC
K99, F41
LT = cAMP, ST = cGMP = irreversible opening of chlore channel
ETEC
EspA, EspB, EspD, intimin
fimbriae S, P
EPEC
Verotoxin, shigatoxin
EHEC
LPS, tue macro type 1
secretory system = caspase 1, apopto
Salmonelle
PA (B) = entry
EF = dysrupt membrane (ATP -AMPc)
LF = destroy MAPK = cell death
anthrax
Vaps
R.equi
Iron chelating prots (exochelin, siderophore, iron reductase)
Mannonse-BR on macro + CD14 = NO CYTOKINE
M.avium pseudotuberculosis
Johne
LsaA= entry
Escape phagocome
reste IC for X
Lawsonia
Hemolysn, protease, hausse mucus
B, hyodysentariae
Kupffer cell, phospholipase C, hemolysin
C.haemolyticum
SzP (Mlike prot), determine organe
C5a peptidase, invasin, fibronectin BP = biofilm
Strep equi zoo
CR1-3-4, MannoseR, CD14
waxy cell wall
Mbovis
Apx1-111 = pore
A. pleuropneumoniae
DNT, hemolysine -> squamous metaplasia
PMT = block osteoblast
Bbronchi
Pmulto
Block fusion phagocyte
LPS, cyclic B-1,2 glucan, HSP
Brucella
SeM, SzPSE = adhesin
SeeH = macro
Streptokinase (plasminogen -> plasmin ->baisse fibrine)
Streptolysin S = pore
Strep equi equi
Internalin A, B via e-cadherin
Listeriolysin O (baisse immune, hausse prolif)
Act A = propel
Listeria monocytogenes
Adhesion factor 1 to CR3 CD14 (alveolar macro)
Blastomycosis
Enters via MBL and CR3 = block phago formation
reconnu par TLR2 (lipoarab), TLR9 (CpG) -> IFNy -> defensin -> autophagy -> NO
Tuberculosis
Recognized by TLR2, lectin-dectin
reconnait 1-3-B glucan in cell wall
Aspergillus
Lypophosphoglycan -> glycocalyx active complement sans MAC, opsonize C3 binds MAC-1 + CR1
Gp63 = cleave complement
Leishmania
Dx cell in mitosis
Ki67
PCNA
AgNOR
Dx cell in apoptosis
caspase
annexin
TUNEL