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Agents infectieux facteur de virulence Flashcards

1
Q

VP4, VP7 = attachement

A

Rotavirus (RNA non E)

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2
Q

NSP4 (enterotixin)

A

Rotavirus RNA non E

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3
Q

Glycoprotein G binds LDL-R
targets squamous epithelium

A

Arbovirus (RNA E)

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4
Q

Glycoprot E1, E2 attache crypt
Lysis PP, necrosis vascular wall

A

BVD (pestivirus, RNA, E)

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5
Q

Target CD150 (lympho)
SLAM

A

Rinderpest (morbili RNA E)

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6
Q

FIL attache heparan-R
synthesis VEGF = angiogenesis

A

Parapox DNA E
Echtyma contagieux

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7
Q

VP1 à 4 attache
R-integrin VB1-3-6

A

Aphtovirus RNA non E
Foot and mouth dz

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8
Q

S prot binds sialic acid in mucus layer
E2 = entry

A

Coronavirus RNA E
GIT

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9
Q

VP14 attache
R=ICAM

A

Enterovirus RNA non E
swine vesicular dz

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10
Q

tropisme endothelial cell -> CIVD

A

Calicivirus RNA non E
exanthème Fe

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11
Q

Need duplex transcription template = only in S phase
R= transferrin (Ca)
R = transferrin, neuraminic acid (Fe)

A

Parvovirus DNA non E

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12
Q

Lysis epithelial/endothelial cells
Fiberprotein = attache
R-integrin (coxackievirus-adenovirus)

A

Phlebovirus DNA non E
Rift valley

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13
Q

HA = entry
NA = shedding
HA/NA bind to target sialligosaccharide

A

Orthomyxovirus RNA E
Influenza Eq

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14
Q

Glycoprot B, C, D = attache
Mediator A, nectin 1-2, 3-0 sulfate heparin = entry
Trigeminal/olfactive nerve (retrograde axonal)
Active by multiplication by axonal transport to mucosa and going into epithelial cells

A

Herpesvirus DNA E
IBR

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15
Q

What does latent virus mean?

A

Latent = NO CMH II. LOW CMH I = less CTL, macro
Virus in nucleus without protein synthesis

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16
Q

Glycoprotein G = attache
Glycoprotein F = fusion
TLR3-4 for inflamm

A

Pneumovirus RNA E
syncitial

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17
Q

Infects monocytes precursors in bone marrow = reservoir
Genome inserted on chromosomal DNA = persiste infection
Chronic inflamm lung, brain, mammary, synovial, demyelinating encephalitis

A

Lentivirus RNA E
Maedivisna

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18
Q

R = Sialoadhesin, CD163, heparan
Acute inflamm mucociliary -> bact infection

A

Arterivirus RNA E
SRRP

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19
Q

Infect injure erythroid precursors
= neonatal anemia

A

Herpesvirus (cytomegalovirus) DNA E
inclusion body rhinitis

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20
Q

PAS CONTAGIEUX
bite from midges
Capside VP2, VP5, NS3 (insertin)
Cytotoxin (viroporin)
Source = semen accessory glands

A

Orbivirus RNA non E
African horse sickness

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21
Q

Lysis vascular endothelium
Lysis lymphocytes
Vasculitis
Dead-end host because spread need free cell virus = don’t exist

A

Gammaherpesvirus DNA E
fièvre catarrhale maligne

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22
Q

Erns, E2 envelop, glycoprotein

A

Pestivirus RNA E
Classical swine fever

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23
Q

Envelop glycoprot = p12, p54, p30

A

Asfivirus DNA E
African swine fever

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24
Q

Glyco = B, C, D
basse temperature helps

A

Canine herpesV type I

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25
Q

Antigenic shift/drift of 3c genes in mucosal macrophages
S1, S2, M, E = attache

A

PIF

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26
Q

What is the immune response in PIF? SC?

A

HIGH cell mediated = no PIF
LOW cell mediated = dry
NO cell mediated = wet
effective HUMORAL = more severe
Adequate AC = hyperS III -> complement => neutro
Type 4 in some pygranulomas

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27
Q

envelop gp120, gp90
R-lentivirus-R-1
Cell free vitus act as hapten on RBC -> phagocyte + présente lympho -> humoral response -> hyperSe II
What happens if haptens active complement?

A

Lentivirus
Anemie infectieuse equine (bloodborne)
active complement = RBC lysis

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28
Q

Changement LB (gene transactivation)
Provirus infected LT
gp51, gp30 enter naive LB = express IgM
CD5, CD11b = susceptible infection
p34tax = prolif LB = X virus + growth/differenciation

A

Deltavirus
Leukemia Bo

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29
Q

Need S phase X
Macro non permissive
Lympho permissive

A

Circovirus 2

30
Q

LB spread virus
LT = #1 target
Need fast dividing cells
Persistent LT infection = clinical signs
Surface Su, TM

A

Retrovirus
Leukemia Fe

31
Q

infect CD4+
SU, TM
Target CD134, CXCR4

A

Lentivirus
FIV

32
Q

Dysrupt neurotransmitter fct
Gprot -> NT-R -> Muscle -> X -> interstitial bind acetylcoA, ganglioside -> retrograde (dynein) -> nerfs 7 (facial), glossopharyngien (9)

A

Lyssavirus
rabies

33
Q

dysfct endo cell of arterioles in brain + spinal cord
immune complex

A

alphaherpesvirus
encephalite equine

34
Q

Target neurons cell bodies
+++ CTL, retrograde axonal

A

alphaherpes
Pseudorabies

35
Q

viral H prot + fusion protein F
R = CD150 (SLAM)

A

Distemper
Morbilivirus

36
Q

NS1 produced by virus = TOXIC

A

Feline parvovirus
cerebral hypoplasia

37
Q

dysfct gene prolif/diff/adhesion
Integrin a6B4 - heparan sulfate = attache
Bovine L1, L2 capside
basal cell = non permissive = reservoir = X genome
virus mature on the way to upper layer = complete cycle
what does it mean if the cell doesn’t go into the target cell? if integrate in suprabaal layer)

A

Viral papilloma
warts, sarcoids
NO = benign (no permissive)
upper = malin (permissive)

38
Q

Action of E5

A

active R-PDGF, EGF
inhibe CMH I

39
Q

action E6

A

Inhibe p53, BAK
active telomerase, BCL2, mTOR, MYC

40
Q

action E7

A

Active HIFa
baisse Rb, p21
favorise bris DNA

41
Q

only between cats
persistent infection of MO (LT precursor) = baisse immun cell mediated = baisse CTL, baisse IFNy, IL secreted by LT, dysfct neutro/macro
R = feline thiamine transport protein

42
Q

Shift recombination of type A
neoplastic change
R = feline phosphate transporter protein 1-2

43
Q

Point mutation (antigenic drift)
anemia
R = FeLVCR

44
Q

Infects LT = immunosuppressive syndrome
R = FePIT1

45
Q

Secreted by LT = restrict tropism to LT

46
Q

caracteristic of reovirus (FeLV)

A

produce reverse transcriptase (reo) to transcribe viral RNA into proviral DNA = insertion chromosome LT

47
Q

Where is FOCMA expressed in FeLV

A

expressed on cell membrane of changed cells
NOT on infected or not transformed cell

48
Q

Type 1 fimbriae, S, P
bind uroplakin-R

49
Q

K99, F41
LT = cAMP, ST = cGMP = irreversible opening of chlore channel

50
Q

EspA, EspB, EspD, intimin
fimbriae S, P

51
Q

Verotoxin, shigatoxin

52
Q

LPS, tue macro type 1
secretory system = caspase 1, apopto

A

Salmonelle

53
Q

PA (B) = entry
EF = dysrupt membrane (ATP -AMPc)
LF = destroy MAPK = cell death

54
Q

Vaps

55
Q

Iron chelating prots (exochelin, siderophore, iron reductase)
Mannonse-BR on macro + CD14 = NO CYTOKINE

A

M.avium pseudotuberculosis
Johne

56
Q

LsaA= entry
Escape phagocome
reste IC for X

57
Q

Hemolysn, protease, hausse mucus

A

B, hyodysentariae

58
Q

Kupffer cell, phospholipase C, hemolysin

A

C.haemolyticum

59
Q

SzP (Mlike prot), determine organe
C5a peptidase, invasin, fibronectin BP = biofilm

A

Strep equi zoo

60
Q

CR1-3-4, MannoseR, CD14
waxy cell wall

61
Q

Apx1-111 = pore

A

A. pleuropneumoniae

62
Q

DNT, hemolysine -> squamous metaplasia
PMT = block osteoblast

A

Bbronchi
Pmulto

63
Q

Block fusion phagocyte
LPS, cyclic B-1,2 glucan, HSP

64
Q

SeM, SzPSE = adhesin
SeeH = macro
Streptokinase (plasminogen -> plasmin ->baisse fibrine)
Streptolysin S = pore

A

Strep equi equi

65
Q

Internalin A, B via e-cadherin
Listeriolysin O (baisse immune, hausse prolif)
Act A = propel

A

Listeria monocytogenes

66
Q

Adhesion factor 1 to CR3 CD14 (alveolar macro)

A

Blastomycosis

67
Q

Enters via MBL and CR3 = block phago formation
reconnu par TLR2 (lipoarab), TLR9 (CpG) -> IFNy -> defensin -> autophagy -> NO

A

Tuberculosis

68
Q

Recognized by TLR2, lectin-dectin
reconnait 1-3-B glucan in cell wall

A

Aspergillus

69
Q

Lypophosphoglycan -> glycocalyx active complement sans MAC, opsonize C3 binds MAC-1 + CR1
Gp63 = cleave complement

A

Leishmania

70
Q

Dx cell in mitosis

A

Ki67
PCNA
AgNOR

71
Q

Dx cell in apoptosis

A

caspase
annexin
TUNEL

Nutrition (13 decks)

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