Agent Specific Supportive Care

Question 1

What drugs are alkylating agents?

Answer 1

cyclophosphamide/ifosfamide

Question 2

What is the enzyme that metabolizes cyclophosphamide?

Answer 2

CYP3A4 and CYP2B6

Question 3

What are the toxicities associated with Cyclophosphamide?

Answer 3

• interstitial pneumonia
• SIADH
• myelosuppression (dose limiting toxicity)
• nausea/vomiting
• alopecia
• amenorrhea/infertility
• cardiotoxicity
• secondary malignancies (bladder cancer or leukemia)
• hemorrhagic cystitis (ifosfamide>cyclophosphamide)

Question 4

What are the toxicities associated with Ifosfamide?

Answer 4

• CNS toxicity/encephalopathy
• nephrotoxicity
• myelosuppression (dose limiting toxicity)
• nausea/vomiting
• alopecia
• amenorrhea/infertility
• cardiotoxicity
• secondary malignancies (bladder cancer or leukemia)
• hemorrhagic cystitis