Affective disorders Flashcards

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1
Q

What are mood (affective) disorders?

What other psychiatric disorders are they often associated with?

A

Disorders of mental status and function where altered mood is the (or a) core feature

This includes states of depression & elevation of mood (mania)

Often associated with anxiety symptoms and anxiety disorders

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2
Q

What causes mood disorders?

A

Can be primary or as a consequence of other illnesses or disorders - such as cancer, dementia, steroid use, drug misuse

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3
Q

What are the 2 classification systems for mood disorders?

A

ICD-10

DSM-5

International classification of disease - 10th edition (used in UK clinical practice)

Diagnostic Statistical manual - 5th edition (USA)

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4
Q

What are the 4 aspects of mood disorders that psychiatrists focus on when making a diagnosis?

A

Persistence of symptoms

Pervasiveness of symptoms

Degree of impairment

Presence of specific symptoms & signs

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5
Q

In diagnosing depression - what is meant by:

a) Persistence of symptoms
b) Pervasiveness of symptoms
c) Degree of impairment
d) Presence of specific symptoms/signs

A

a) Persistence - of symptoms of at least 2 weeks
b) Pervasiveness - symptoms experienced throughout most of the day
c) Impairment - restriction on tasks of everyday life
d) Specific symptoms/signs - psychological, physical, social

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6
Q

What are the 3 groups (spheres) of symptoms of a depressive episode?

A

Psychological

Physical

Social

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7
Q

What are the psychological symptoms that patients suffering from a depressive episode may experience?

A

Change in mood:

  • depression
  • anxiety
  • perplexity (esp in puerperal illness) - being overwhelmed
  • anhedonia - no pleasure from the things you previously enjoyed doing

Changes in thought content:

  • guilt
  • hopelessness
  • worthlessness
  • neurotic symptoms - hypochondriasis, agorophobia etc
  • ideas of reference
  • psychotic symptoms - hallucinations & delusions
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8
Q

Presence of neurotic symptoms are changes of thought content that can indicate a depressive episode.

What are examples of neurotic symptomatology?

A

Hypochondriasis - worrying about health

Agorophobia - fear/resentment to leave ones house

Obsessions & compulsions

Panic attacks

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9
Q

What is meant by ideas of reference?

A

When an individual believes something happening that is unrelated to them in their environment is infact related to them

So if a person is walking down the street and sees random people laughing and believes that they are laughing at him/her without evidence - that would be an idea of reference

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10
Q

What is the difference between hallucinations and delusions?

A

Hallucinations - sensory experience of something that is not present

Delusions - strong, unshakeable belief about something with no evidence to support it (ie a belief that your organs are rotting)

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11
Q

What are the physical symptoms of depression?

A

Change in bodily function:

  • energy
  • appetite
  • sleep
  • libido
  • constipation
  • pain

Change in psychomotor function:

  • agitation
  • retardation & stupor
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12
Q

What are the social symptoms of a depressive episode?

A

Loss of interests (anhedonia)

Irritability

Apathy

Withdrawel, loss of confidence, indecisive

Loss of concentration, registration, memory

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13
Q

What is stupor?

A

A state of extreme retardation (slowing of motor responses) in which consciousness is intact

The patient stops moving, speaking, eating or drinking but can recall everything they experienced while stuporose - after they recover

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14
Q

For the diagnosis of depression using ICD-10 - what criteria must be met?

A

Symptoms >2 weeks

No hypomanic or manic episode in lifetime

Not attributable to psychoactive substance use or organic mental disorder

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15
Q

If a patient has a history suggestive of severe depression with psychotic symptoms - what conditions must be excluded before this diagnosis can be made?

A

Exclude other psychotic illnesses such as Schizophrenia

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16
Q

Somatic syndrome is a specific type of depression. What are the features that characterise it?

A

Anhedonia

Waking early (2 hours)

Morning depression

Psychomotor agitation or retardation

Loss of appetite & weight

Loss of libido

17
Q

What is post-natal depression and how common is it?

A

Depressive episodes that affect women after they have delivered a child

75% of women get ‘blues’ in the 2 weeks following delivery

10% of women experience MDD* within 3-6 months

1/500 women experience ‘puerperal psychosis’

18
Q

What are the diffs for depressive episodes?

A

Normal reaction to life event

Seasonal Affective Disorder

Dysthymia

Cyclothymia

Bipolar

Stroke, tumour, dementia

Hypothyroidism, Addison’s, Hyperparathyroidism

Infections – Influenza, infectious mononucleosis, hepatitis, HIV/AIDS

Drugs

19
Q

Give an overview of the treatments for depression

A

Antidepressants:

  • SSRIs - first line
  • TCAs
  • Monamine oxidase inhibitors
  • Others

Psychological:

  • CBT, IPT etc

Physical:

  • ECT
  • Psychosurgery
  • DBS, VNS
20
Q

What is mania?

A

State of elevated mood - characterised by:

grandiose ideas

disinhibition

loss of judgement

Similarities to the effects of amphetamines and cocaine

21
Q

What general symptoms and signs are seen in manic episodes?

A

Elevation of mood, energy and feeling of wellbeing - with features such as:

  • Increased talkativeness, sociability, libido
  • Overfamiliarity
  • Decreased need for sleep
  • May be irritable
  • Reduced concentration
  • New interests
  • Disinhibition - both socially and financially
  • may have psychosis
22
Q

What is hypomania?

A

Lesser degree of mania - without psychosis:

  • Mild elevation of mood for several days on end
  • Manic symptoms* - but not to the degree of severe disruption of work or social rejection

* see photo for details of symptoms

23
Q

What are the features of ICD-10 Mania?

A

Manic episode lasting >1 week - with or without psychosis:

  • severe enough to disrupt work & social life
  • Elevated mood & energy, overactivity with decreased sleep
  • may be irritable

Specific features:

  • grandiosity
  • increased pressure of speech
  • disinhibition
  • alteration of senses
  • extravagent spending
24
Q

What tools are used to measure symptoms of mania?

A

SCID

SCAN

Young mania rating scale (YMRS)

SCID & SCAN also used for depression

25
Q

What is Bipolar affective disorder?

A

BAD consists of repeated (2+) episodes of depression and mania or hypomania

26
Q

What is the diagnosis if a patient has multiple episodes of depression without mania/hypomania?

What is the diagnosis if a patient has episodes of mania without depression?

A

No mania/hypomania = Recurrent depression

No depression = hypomania or bipolar disorder*

*A single episode of mania is enough to diagnose bipolar (DSM-5)

27
Q

Concerning the epidemiology of bipolar disorder, what are the differences between…

a) males and females
b) developing and developed countries

A

a) males = females
b) developed = developing

28
Q

What is the typical age of onset of bipolar disorder?

What factors may predispose an individual to developing BAD earlier?

A

mean age = 21

1/3rd <20

unusual >30

Early onset (teens) usually with positive family history

29
Q

Concerning the epidemiology of depression, what is the:

a) difference in the prevalence between males and females
b) mean age of onset (and spread of age of onset)

A

a) Females exceed males 2:1 - but male suicide is much more common
b) mean age 27 - but much more variability than BAD - ie its not unusual for a 70 year old to develop depression

30
Q
A