Adverse Reactions to Drugs Flashcards
Which of the following is NOT associated with Lichenoid eruptions?
ACEi NSAIDs Methyldopa Nicorandil Gold
Lichenoid eruptions: Methyldopa Chloroquine Thiazide diuretics (BendroFLUmethiazide - agranulocytosis) Antidiabetics
Lichenoid eruptions + Oral ulceration:
ACEi
Gold
NSAIDs
Oral Ucleration: NICORANDIL (and anal) Pancreatin Penicillamine Proguanil HCl Protease inhibitors
Which of the following is NOT associated with oral ulceration?
ACEi Gold Penicillamine Chloroquine Proguanil HCl Thiazide diuretics
Lichenoid eruptions: Methyldopa Chloroquine Thiazide diuretics (BendroFLUmethiazide - agranulocytosis) Antidiabetics
Lichenoid eruptions + Oral ulceration:
ACEi
Gold
NSAIDs
Oral Ucleration: NICORANDIL (and anal) Pancreatin Penicillamine Proguanil HCl Protease inhibitors
Which of the following IS associated with oral ulceration?
Methyldopa Chloroquine Thiazide diuretics Gold Oral antidiabetics
Lichenoid eruptions: Methyldopa Chloroquine Thiazide diuretics (BendroFLUmethiazide - agranulocytosis) Antidiabetics
Lichenoid eruptions + Oral ulceration:
ACEi
Gold
NSAIDs
Oral Ucleration: NICORANDIL (and anal) Pancreatin Penicillamine Proguanil HCl Protease inhibitors
NB: Stevens-Johnsons can present with extensive ulceration of the oral mucosa but usually not the only symptom.
Which of the following IS associated with Lichenoid eruptions ONLY?
NSAIDs
ACEi
Chloroquine
Gold
Lichenoid eruptions: Methyldopa Chloroquine Thiazide diuretics (BendroFLUmethiazide - agranulocytosis) Antidiabetics
Lichenoid eruptions + Oral ulceration:
ACEi
Gold
NSAIDs
Oral Ucleration: NICORANDIL (and anal) Pancreatin Penicillamine Proguanil HCl Protease inhibitors
What drug used for copper poisoning/too much copper can also cause oral ulceration?
Penicillamine.
Lichenoid eruptions: Methyldopa Chloroquine Thiazide diuretics (BendroFLUmethiazide - agranulocytosis) Antidiabetics
Lichenoid eruptions + Oral ulceration:
ACEi
Gold
NSAIDs
Oral Ucleration: NICORANDIL (and anal) Pancreatin Penicillamine Proguanil HCl Protease inhibitors
What drug which can be used for hypertension in pregnancy can also cause lichenoid eruptions?
Lichenoid eruptions:
Methyldopa «_space;(Also labetolol and nifedipine [used less] when managing hypertension in pregnancy but they dont cause lichenoid eruptions)
Chloroquine
Thiazide diuretics (BendroFLUmethiazide - agranulocytosis)
Antidiabetics
Lichenoid eruptions + Oral ulceration:
ACEi
Gold
NSAIDs
Oral Ucleration: NICORANDIL (and anal) Pancreatin Penicillamine Proguanil HCl Protease inhibitors
What antimalarial can cause oral ulceration?
Lichenoid eruptions: Methyldopa Chloroquine Thiazide diuretics (BendroFLUmethiazide - agranulocytosis) Antidiabetics
Lichenoid eruptions + Oral ulceration:
ACEi
Gold
NSAIDs
Oral Ucleration: Nicorandil (and anal) Pancreatin Penicillamine Proguanil HCl <<< Protease inhibitors
What drug which might be used for exocrine pancreatic defiency in CF may cause oral ulcerations?
Lichenoid eruptions: Methyldopa Chloroquine Thiazide diuretics (BendroFLUmethiazide - agranulocytosis) Antidiabetics
Lichenoid eruptions + Oral ulceration:
ACEi
Gold
NSAIDs
Oral Ucleration: Nicorandil (and anal) Pancreatin <<<<< Penicillamine Proguanil HCl Protease inhibitors
What antimalarial (which is not used in many areas due to resistance) can cause lichenoid eruptions?
Lichenoid eruptions: Methyldopa Chloroquine <<<< Thiazide diuretics (BendroFLUmethiazide - agranulocytosis) Antidiabetics
Lichenoid eruptions + Oral ulceration:
ACEi
Gold
NSAIDs
Oral Ucleration: Nicorandil (and anal) Pancreatin Penicillamine Proguanil HCl Protease inhibitors
What drug class commonly used in the management of hypertension could cause oral ulceration and/or lichenoid eruptions?
Lichenoid eruptions: Methyldopa Chloroquine Thiazide diuretics (BendroFLUmethiazide - agranulocytosis) Antidiabetics
Lichenoid eruptions + Oral ulceration:
ACEi ««
Gold
NSAIDs
Oral Ucleration: Nicorandil (and anal) Pancreatin Penicillamine Proguanil HCl Protease inhibitors
Which OTC antiplatelt/antipyretic/analgesic can cause oral ulceration?
When would this happen?
Aspirin tablets allowed to dissolve in the sulcus for the treatment of toothache can lead to a white patch followed by ulceration.
What can stain the teeth?
- Brown staining of the teeth frequently follows the use of chlorhexidine mouthwash, spray or gel, but can readily be removed by polishing.
- Iron salts in liquid form can stain the enamel black.
- Superficial staining has been reported rarely with co-amoxiclav suspension.
- Intrinsic staining of the teeth is most commonly caused by tetracyclines. They will affect the teeth if given at any time from about the fourth month in utero until the age of twelve years; they are contra-indicated during pregnancy, in breast-feeding women, and in children under 12 years. All tetracyclines can cause permanent, unsightly staining in children, the colour varying from yellow to grey.
The risk of osteonecrosis of the jaw is substantially greater for patients receiving intravenous bisphosphonates in the treatment of cancer than for patients receiving oral bisphosphonates for osteoporosis or for what disease?
The risk of osteonecrosis of the jaw is substantially greater for patients receiving intravenous bisphosphonates in the treatment of cancer than for patients receiving oral bisphosphonates for osteoporosis or Paget’s disease.
Paget’s disease of bone interferes with your body’s normal recycling process, in which new bone tissue gradually replaces old bone tissue.
Patients with cancer may also be at risk of osteonecrosis of the jaw if they use which treatments?
Bevacizumab: VEGF targeter.
Sunitinib: RTK inhibitor
Gingival overgrowth is a side effect seen most commonly caused by what three drugs?
- Phenytoin
- Sometimes ciclosporin
- Sometimes Nifedipine (and other CCB)
Which of the following drugs may cause an INCREASE in saliva production?
Baclofen Bupropion Clonidine Clozapine Opioids Tizanidine.
Xerostomia (decreased salivia): Antimuscarinics (anticholinergics) Antidepressants (including TCAs and SSRIs) Alpha-blockers Antihistamines Antipsychotics Baclofen Bupropion Clonidine Hydrochloride 5HT1-agonists Opioids Tizanidine Excessive use of diuretics.
Increased saliva production:
Clozapine
Neostigmine
Which antipyschotic is associated with increased saliva production?
Xerostomia (decreased salivia): Antimuscarinics (anticholinergics) Antidepressants (including TCAs and SSRIs) Alpha-blockers Antihistamines Antipsychotics Baclofen Bupropion Clonidine Hydrochloride 5HT1-agonists Opioids Tizanidine Excessive use of diuretics.
Increased saliva production:
Clozapine
Neostigmine