Adverse reactions Flashcards
1
Q
Adverse reaction of gentamicin + vancomycin?
A
otoxicity + nephrotoxicity
2
Q
Adverse reaction of antibiotics (broad-spec like cephalosporins or ciprofloxacin)?
A
C.diff colitis
3
Q
Adverse reaction of ACE inhibitors (lisinopril)
A
- hypotension
- electrolyte abnormalities - raised k, low na
- AKI
- dry cough
4
Q
Adverse reaction of beta-blockers
A
- hypotension
- bradycardia
- wheeze (asthmatics CI)
- worsens acute HF
fatigue less recognised
5
Q
Adverse reaction of CCBs (diltiazem, verapamil)
A
- hypotension
- bradycardia
- flushing
- peripheral oedema
6
Q
Adverse reaction of diuretics (furosemide, bendro, spiro)?
A
- hypotension
- electrolyte abnormalities
- AKI
class dependent (spiro = gynaecomastia) (thiazide = gout)
7
Q
Adverse reaction of heparin?
A
- haemorrhage
- HIIT
8
Q
Adverse reaction of warfarin?
A
- haemorrhage –> note bridging with LMWH required until INR 2
9
Q
Adverse reaction of aspirin?
A
- haemorrge
- peptic ulcer + gastritis
- tinnitus in large dose
10
Q
Adverse reaction of digoxin
A
- nausea, vomiting, diarrhoea
- confusion, drowsiness
- blurred vision or yellow/green perception, halo vision
11
Q
Effect of K+ on digoxin effectiveness?
A
- low K+ increases effectiveness
- high K+ reduced effect
12
Q
Adverse reaction of amIOdarone?
A
- ILD (pulmonary fibrosis)
- thyroid disease (hypo + hyper)
- skin grey
- corneal deposits
13
Q
Adverse reaction of lithium
A
early = tremor intermediate = tiredness late = arrhythmias, seizures + coma, renal failure, diabetes insipidus
14
Q
Adverse reaction of haloperidol?
A
- dyskinesias (acute dystonic reactions)
- drowsiness
15
Q
Adverse reaction of clozapine?
A
- agranulocytosis - intensive FBC monitoring
