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adverse Flashcards

so many bad things to say about these drugz

1
Q

adverse

a-methyl-dopa

pro-drug

A 
dizziness
sex dysfx'n
sedation
withdrawal HTN syndrome
autoimmune dysfx'n (Coombs)
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2
Q

adverse

acetylcholine

A 
HTN
GI (diarrhea)
bronchoconstriction
(contra'd asthma)
contra'd heart dz, peptic ulcer, GI
obstruction
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3
Q

adverse

adenosine

A

dyspnea
flushing
hypotension

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4
Q

adverse

albuterol

A

B1 stim at high dose

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5
Q

adverse

amiodarone

A

long Qt > Torsades
pulmonary fibrosis
rhabdomyolysis (w/ simvastatin)

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6
Q

adverse

amlodipine

A

short-acting nifidipine
(cause MI)
contra’d HF

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7
Q

adverse

amphetamine

A

addiction/abuse

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8
Q

adverse

Atenolol

A 
decreased CO
heart block
bradycardia
bronchospasm at high dose
(due to B2 antagonism)
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9
Q

adverse

atorvastatin

A 
contra'd PG, nursing
drug interactions
(gemfibrozil inhibits)
myopathy
rhabdomyolysis
reversible cog fx >50 yo
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10
Q

adverse

atropine

A

tachycardia
urinary retention
glaucoma

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11
Q

adverse

bethanechol

A 
HTN
GI (diarrhea)
bronchoconstriction
(contra'd asthma)
contra'd heart dz, peptic ulcer, GI
obstruction
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12
Q

adverse

botulinum toxin

A

excessive paralysis

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13
Q

adverse

captopril

A 
increase bradykinin levels
(dry cough)
contra'd bilat renal stenosis
contra'd PG
dry cough
tachycardia
lupus
headache
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14
Q

adverse

carbachol

A 
HTN
GI (diarrhea)
bronchoconstriction
(contra'd asthma)
contra'd heart dz, peptic ulcer, GI
obstruction
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15
Q

adverse

carvediLOL

A 
hypotension
bradycardia
bronchospasm
(contra'd in asthma)
decreased CO
heart block
depression
lethargy
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16
Q

adverse

cholestyramine

A 
increase VLDL, TAGs
contra'd hyperTAGemia
GI side effects
rare vit K malabsorption
impedes absorption of drugs
(warfarin, digoxin, thiazides)
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17
Q

adverse

Clonidine

A

dizziness
sex dysfx’n
sedation
withdrawal HTN syndrome

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18
Q

adverse

cocaine

A

addiction, nosey wosey

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19
Q

adverse

digoxin

A 
AV block high dose and with
aldosterone inhibitors
narrow therapeutic index
hyperkalemia
anorexia, nausea, vomit
quinidine and amiodarone increase
cholestyramine reduces
can CAUSE arrhythmia
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20
Q

adverse

diltiazem

A 
constipation
AV block
bradycardia
CHF
contra'd in HF
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21
Q

adverse

Dobutamine

A

angina
chemotrigger nausea
arrhythmia
doesn’t cross to CNS

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22
Q

adverse

dopamine

A

arrhythmia
angina
chemotrigger nausea
does not cross to CNS

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23
Q

adverse

enalaPRIL

A 
dry cough
tachycardia
lupus
headache
renal insufficiency (esp w/ bilateral
renal aa stenosis)
contra'd pregnancy
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24
Q

adverse

ephedrine

A

increase BP

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25
Q

adverse

epinephrine

A 
anxiety
headache
palpitations
tremors
arrhythmia
CVA
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26
Q

adverse

eplerenONE

A

hyperkalemia

w/ digoxin can cause AV block

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27
Q

adverse

Esmolol

A 
decreased CO
heart block
bradycardia
bronchospasm at high dose
(due to B2 antagonism)
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28
Q

adverse

Ezetimibe

A

no D-D interactions!
test liver befor admin
low hepatotoxicity

29
Q

adverse

flecainide

A

ataxia

uncoordination

30
Q

adverse

furosemide

A

hypokalemia

31
Q

adverse

gemfibrozil

A 
inhibits statin absorption
potentiates warfarin
contra'd in renal/hepatic dz
Contra'd PG
Contra'd peds
GI fx
rhabdomyolysis risk with statin
32
Q

adverse

Guanethidine

A

postural HTN
sex dysfx’n
diarrhea

33
Q

adverse

Hydralazine

A

Baroreflex

Contra’d CAD, >40yo

34
Q

adverse

hydrochlorothiazide

A

Contra’d renal dz
sexual dysfx’n
increase risk arrhythmia

35
Q

adverse

ipratropium

A

tachycardia
urinary retention
glaucoma

36
Q

adverse

isoprotenerol

A

arrhythmia
tachycardia
palpitations
angina

37
Q

adverse

isosorbide dinitrate

A

hypotension
headache
contra’d VIAGRA
RHF

38
Q

adverse

lidocaine

A

respiratory arrest

convulsions

39
Q

adverse

losartan

A

contra’d bilat renal stenosis

contra’d PG

40
Q

adverse

metoprolol

A 
Contra'd with Wolff-Parkinson
hypotension
bradycardia
bronchospasm
contra'd in asthma
41
Q

adverse

mexiletine

A

respiratory arrest

convulsions

42
Q

adverse

Minoxidil

A

Baroreflex

Contra’d CAD

43
Q

adverse

niacin

A 
Cutaneous flushing
vasodilation (take aspirin)
hepatotoxicity
Gi fx (contra'd peptic dz)
Contra'd PG
44
Q

adverse

nifedipine

A 
constipation
AV block
bradycardia
CHF
contra'd in HF
45
Q

adverse

nimodipine

A 
constipation
AV block
bradycardia
CHF
contra'd in HF
46
Q

adverse

NITroglycerin

A

hypotension
headache
contra’d VIAGRA
RHF

47
Q

adverse

norepinephrine

A 
anxiety
headache
palpitations
tremors
arrhythmia
CVA
48
Q

adverse

phentolamine

A

^^tachycardia
(reflex + increased NE
at B1 receptors)

49
Q

adverse

phenylephrine

A

increase BP

50
Q

adverse

phenyloxybenzamine

A

reflex tachycardia
orthostatic HTN
sex dysfx’n
congestion

51
Q

adverse

pravastatin

A

no D-D interactions!

otherwise same fx

52
Q

adverse

Prazosin

A 
"1st dose phenom"
Na retention
reflex tachycardia
orthostatic HTN
sex dysfx'n
congestion
53
Q

adverse

procainamide

A 
slowing aFib SA might raise AV
and cause vTac
Asystole w/ AV block
Long QT syndrome, Torsades
fever, diarrhea, lupus-ish
54
Q

adverse

Propanolol

A 
HoTN
decreased CO
heart block
bradycardia
bronchoconstriction (B2)
contra'd asthma
depression
lethargy
ED
insomnia
55
Q

adverse

quinidine

A 
slowing aFib SA might raise AV
and cause vTac
Asystole w/ AV block
Long QT syndrome, Torsades
fever, diarrhea, lupus-ish
56
Q

adverse

Reserpine

A

sedation
impaired concentration
depression
orthostatic HTN

57
Q

adverse

sarin gas

A 
bioterror!!!
SLUDGE
resp paralysis
convulsions
coma
ataxia
58
Q

adverse

Sodium nitroprusside

A

Contra’d Viagra

59
Q

adverse

sotalol

A

long Qt > Torsades

rhabdomyolysis (w/ simvastatin)

60
Q

adverse

sprinolactONE

A

hyperkalemia

w/ digoxin can cause AV block

61
Q

adverse

succinylcholine

A 
muscle fasciculations
contra'd: atypical Ach-erase
hyperthermia
hyperkalema 
(arrhythmias)
contra'd renal dysfx'n, burn pts
62
Q

adverse

terbutaline

A

B1 stim at high dose

63
Q

adverse

thiazide

A

hypokalemia

64
Q

adverse

Timolol

A 
decreased CO
heart block
bradycardia
bronchoconstriction (B2)
contra'd asthma
depression
lethargy
65
Q

adverse

tubocurarine

A

contra’d aminoglycosides
contra’d inhalation anesthetics
HTN
histamin release

66
Q

adverse

tyramine

A

Contra’d w/ MAOIs

67
Q

adverse

varenicline

Chantix

A

neuropsychiatric sx
suicide
depression

68
Q

adverse

vecuronium

A

contra’d aminoglycosides
contra’d inhalation anesthetics
HTN
histamin release

69
Q

adverse

verapamil

A 
constipation
AV block
bradycardia
CHF
contra'd in HF

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