Advances in Local Anesthesia

Question 1

What meds are in Kovanaze nasal spray nesthetic?

Answer 1

3% tetracaine, 0.05% oxymetazoline

Question 2

What is oxymetazoline?

Answer 2

Selective adrenergic receptor agonist and adrenergic receptor partial agonist

Also used as a topical decongestant (Afrin)

Question 3

What is the MRD or recommended dosage of Kovanaze spray?

Answer 3

2 sprays in each nostril. A 3rd if the 2 are not effective

Question 4

Which nerves are anesthetized by Kovanaze spray?

Answer 4

Mostly the ASA and part of the MSA

Canine to canine is very predictable, premolar to premolar fairly predictable

Question 5

What are some quality of life issues associated with prolonged lip and tongue numbness?

Answer 5

Speaking, eating, smiling and drooling

In children: traumatic injury from lip/tongue biting

Question 6

What is phentolamine mesylate used for?

Answer 6

Reversal of soft tissue anesthesia

Question 7

What is the mechanism of action for phentolamine mesylate?

Answer 7

Nonselective adrenergic blocker

Vascular dilation

Question 8

Medically approved indications for use of phentolamine mesylate

Answer 8

Tissue necrosis from leakage of norepinephrine from vasculature

For the reversal of soft tissue anesthesia and associated functional deficits resulting from an intraoral injection of local anesthetic containing a vasoconstrictor.

Question 9

What is the market name for phentolamine mesylate?

Answer 9

Oraverse