Adrenergic Neuronal Inhibitors Flashcards
What do centrally- acting Adrenergic neuronal inhibitors do?
They block alpha 2 receptors in the central nervous system.
What is the list of centrally- acting sympathetic neuronal blockers?
Methyldopa
Clonidine
Guanabenz
Guanfacine
What is the mechanism of action for central acting Adrenergic neuronal inhibitors?
A2 receptor antagonists
Most prominent effects in central a2 sites than peripheral
Different a2 receptor subtypes
They suppress NE and suppress sympathetic outflow from the CNS
What is the mechanism of action for Methyldopa?
Methyldopa is a prodrug converted to methylnorepinephrine
A2 Adrenergic agonist in central vasomotor centers
Methyldopa dampens the outflow if sympathetic nerve activity is peripheral CV tissues.
Decrease if Renal Renin Release, Heart Rate, Cardiac output, Peripheral resistance.
What is the clinical use of Methyl Dopa?
Treatment of hypertension in pregnancy.
Hat are the adverse effects of Methyldopa?
Peripheral fluid retention, dry mouth, sedation
Unique to Methyldopa: Autoimmune disorder positive Coombs test.
Abnormal Liver Test- Hepatic Necrosis
What is the mechanism of action for Clonidine?
Clonidine is a direct a2 Adrenergic agonist. Decreases sympathetic output from CNS vasomotor centers.
What are the clinical uses for Clonidine?
Primary Hypertension
Transdermal patch or immediate release.
Other: ADHD. pain management, opioid withdrawal, menopause issues, apraclonodine for intraocular pressure.
What are the adverse effects of Clonidine?
Clonidine can cause dry mouth and sedation.
Rebound hypertension with abrupt cessation.
What is the primary use of Guanfacine?
Primary use of Guanfacine is Primary Hypertension
And ADHD
